A5070651908- Biochemical Analysis and Sensing Techniques
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hormonal Regulation and Hypertension
- Diet, Metabolism, and Disease
- Long-Term Effects of COVID-19
- Renin-Angiotensin System Studies
- Erythrocyte Function and Pathophysiology
- Prenatal Screening and Diagnostics
- Vitamin C and Antioxidants Research
- Blood properties and coagulation
- Phagocytosis and Immune Regulation
- Infrared Thermography in Medicine
- Cancer, Stress, Anesthesia, and Immune Response
- Gastroesophageal reflux and treatments
- Metabolism and Genetic Disorders
- Bioactive Natural Diterpenoids Research
- Immune cells in cancer
- Metabolomics and Mass Spectrometry Studies
- Fatty Acid Research and Health
- Food Security and Health in Diverse Populations
- Geriatric Care and Nursing Homes
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Frailty in Older Adults
King Saud bin Abdulaziz University for Health Sciences
2020-2024
Cleveland Clinic Lerner College of Medicine
2016-2024
National Guard Health Affairs
2021-2023
King Abdulaziz Medical City
2021-2023
King Abdullah International Medical Research Center
2020-2023
College of Medical Sciences
2021
King Saud University
2020-2021
Virginia Commonwealth University
2020
Cleveland State University
2016-2017
Systemic levels of trimethylamine N-oxide (TMAO), a pro-atherogenic and pro-thrombotic metabolite produced from gut microbiota metabolism dietary (TMA)-containing nutrients such as choline or carnitine, predict incident cardiovascular event risks in stable primary secondary prevention subjects. However, the prognostic value TMAO setting acute coronary syndromes (ACS) remains unknown.We investigated relationship with among sequential patients presenting ACS two independent cohorts. In...
Abstract Background and Aims The pathways metabolites that contribute to residual cardiovascular disease risks are unclear. Low-calorie sweeteners widely used sugar substitutes in processed foods with presumed health benefits. Many low-calorie alcohols also produced endogenously, albeit at levels over 1000-fold lower than observed following consumption as a substitute. Methods Untargeted metabolomics studies were performed on overnight fasting plasma samples discovery cohort (n = 1157) of...
A purified spike (S) glycoprotein of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) was used to study its effects on THP-1 macrophages, peripheral blood mononuclear cells (PBMCs), and HUVEC cells. The S protein mediates the entry SARS-CoV-2 into through binding angiotensin-converting enzyme (ACE2) receptors. We measured viability, intracellular cytokine release, oxidative stress, proinflammatory markers, THP-1-like macrophage polarization. observed an increase in...
Abstract Purpose To investigate and compare the translucency color stability of a newly introduced polymer‐infiltrated ceramic network (PICN) material (Crystal Ultra) to those clinically well‐established restorative materials. Materials Methods A total 80 specimens measuring (12 × 14 1 mm ± 0.05 mm) were prepared from five CAD/CAM (IPS e.max (IPS), Lava Ultimate (LU), Cerasmart (CS), Vita Enamic (VE), Crystal Ultra (CU)) high (HT) blocks in A2 or equivalent shades. Specimens randomly...
All active natural molecules are not fully exploited as therapeutic agents, causing delays in the advancement of anticancer drug discovery. Viridiflorol is a volatile element that may work anti-cancer compound. We tested properties viridiflorol at different concentrations ranging from 0.03 to 300 μM vitro on three cancer cells including breast (MCF-7), lung (A549) and brain (Daoy). The responses were documented after treatment using MTT Annexin V assays. showed cytotoxic effects against all...
Dysregulation of renin−angiotensin systems during coronavirus disease 2019 (COVID-19) infection worsens the symptoms and contributes to COVID-19 severity mortality. This study sought investigate effect exogenous angiotensin II (Ang-II) on severe acute respiratory syndrome 2 (SARS-CoV-2)-specific T-cells response in recovered patients. Human peripheral blood mononuclear cells (PBMCs) were treated with Ang then stimulated a SARS-CoV-2 peptide pool. T-cell responses measured using flow...
Chemotherapy-induced anemia (CIA) is a major obstacle in cancer management. Although the mechanisms governing CIA are poorly understood, recent efforts have identified suicidal erythrocyte (red blood cell, RBC) death as possible cause of CIA. [6]-Gingerol (GNG), polyphenol extracted from Zingiber officinale plant, exhibits wide array biological activities including antimicrobial, antioxidant, anti-inflammatory, immunomodulatory, and anticancer activities, vitro vivo. However, potential...
Nickel (Ni) is an abundant environmental hazard and occupational pollutant. Exposure to Ni compounds prevalent in electroplating workers the printing industry, among others. The toxicity of manifests as dermatological, gastrointestinal, respiratory, allergic, cardiovascular symptoms. In particular, hyperbilirubinemia reticulocytosis have been detected intoxicated subjects; observation possibly implicating selective red blood cell (RBC) toxicity. Herein, interaction nickel chloride (NiCl2)...
Allicin (ACN), a sulfoxide in freshly crushed garlic, is known for its diverse bioactive properties. Among the most notable effects of ACN antitumor activity against wide array cancer types. Thus, may be promising anticancer therapeutic. Nevertheless, chemotherapy-induced anemia major obstacle management with prevalence up to 70%. Although pathophysiology behind it remains elusive, number medications cause patients have been shown induce premature programmed cell death red blood cells (RBCs)...
The prevalence of cancer-associated anemia (CIA) is high, and the mechanisms governing its development remain poorly understood. Eryptosis, suicidal cell death red blood cells (RBCs), may account for CIA as it triggered by clinically approved chemotherapeutics including cisplatin paclitaxel. Physcion (PSN), an anthraquinone extracted from rhubarb other plants, has shown great promise anticancer agent. However, potential toxicity PSN to RBCs remains elusive. were isolated heparinized blood,...
Treatment of severe cases coronavirus disease 2019 (COVID-19) is extremely important to minimize death and end-organ damage. Here we performed a proteomic analysis plasma samples from mild, moderate COVID-19 patients. Analysis revealed differentially expressed proteins different therapeutic potential targets related innate immune responses such as fetuin-A, tetranectin (TN) paraoxonase-1 (PON1). Furthermore, protein changes in showed dysregulation complement coagulation cascades patients...
Risk factors of cardiovascular disease include dyslipidemia, hypertension (HTN), and anemia. Our objective is to assess the patterns dyslipidemia in anemic non-anemic hypertensive Saudi population.A retrospective, cross-sectional study gender, blood pressure, lipid markers, CBC parameters 3111 subjects, which were retrieved from database Al-Borg Medical Laboratories over a six-year period (2014-2019), was carried out. Means compared among groups prevalence, association, diagnostic accuracy...
Abstract Background Noninvasive prenatal testing (NIPT) is a screening tool for chromosomal aneuploidies. Prior knowledge of NIPT an inherent factor in the decision‐making process. We assessed and attitude pregnant women related to with particular focus on NIPT. Methods A prospective cross‐sectional study, using culturally validated questionnaire, was conducted 342 whom 74.9% consented screening. Mean age gestational weeks ± standard deviation 31 5 26 11, respectively. Results positive/very...
Low-calorie sweeteners are substitutes for sugar and frequently used by patients with cardiometabolic diseases. Erythritol, a natural low-calorie alcohol, was linked to diseases in several recent metabolomics studies. However, the characterization of its role disease development is lacking. Macrophage polarization orchestrates immune response various inflammatory conditions, most notably disease. Therefore, physiological effects Erythritol on THP-1 macrophages were investigated. We observed...
Angiotensin II (Ang II) is a major component of the renin–angiotensin or renin–angiotensin–aldosterone system, which main element found to be involved in cardiopathology. Recently, long-term metabolomics studies have linked high levels angiotensin plasma inflammatory conditions such as coronary heart disease, obesity, and type 2 diabetes. Monocyte/macrophage cellular function phenotype orchestrate response various pathological conditions, most notably cardiometabolic disease. An activation...
Brief summary: This observational study in three different cohorts found an increased risk for atherothrombotic disease associated with the commonly used sugar substitute erythritol. Untargeted metabolomics (in cohort 1, n=1157) and targeted 2 3, n=2149 USA n=833 Europe, respectively) investigations revealed major adverse cardiovascular events (MACE) including death, myocardial infarction stroke persons circulating levels of multiple polyol sweeteners such as At physiological levels,...
Background: Acute respiratory distress syndrome (ARDS) is a distinctive feature of severe COVID-19 infections that occurs mainly in patients with coexisting health problems, such as hypertension, atherosclerosis, and diabetes. Endothelial dysfunction major contributing factor during ARDS development pre-existing comorbidities. Objective: Studying the mechanism by which endothelial activation could provide therapeutic target for treatment. Design method: The current study measured oxidative...
Trimethylaminuria (TMAU) is a rare recessive genetic disorder with limited global prevalence. To date, there have been no official reports of TMAU cases documented in Saudi Arabia.
Abstract Erythritol (ERT) is a simple four-carbon sugar alcohol, that produced endogenously via pentose phosphate pathway from glucose in all human cells mainly erythrocytes with plasma level of ∼9.8 μM. It can be obtained exogenously diets as an FDA-artificial sweetener. possesses hydroxyl groups are responsible for radical scavenging effect (antioxidant property). Recent studies have pointed out ERT protection based on concentration dependant endothelial cells. The includes surviving death...
<h3>Objectives:</h3> To translate and cross-culturally adapt a Swedish questionnaire to Arabic assess the awareness of pregnant women in Saudi Arabia regarding availability an accurate safe prenatal screening procedure. <h3>Methods:</h3> The study was conducted at Obstetrics Gynecology Clinic, King Abdulaziz Medical City, Riyadh, between December 2018 April 2019. non-invasive testing (NIPT) questionnaire, translated validated Arabic. Cronbach’s alpha reliability carried out validate version...
Background: Coronavirus disease 2019 (COVID-19) is an emerging respiratory caused by severe acute syndrome coronavirus 2 (SARS-CoV-2). Recent studies have suggested numerous hypotheses that may explain multi-organ dysfunction during a COVID-19 infection. One possible hypothesis posits the renin-angiotensin system dysregulation before SARS-CoV-2 infection could exacerbate symptoms and severity, especially in patients with underlying comorbidities. Objective: This study sought to investigate...