A5042526258- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Breast Cancer Treatment Studies
- Acute Myeloid Leukemia Research
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Helicobacter pylori-related gastroenterology studies
- Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
- Genomic variations and chromosomal abnormalities
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- BRCA gene mutations in cancer
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Advanced Breast Cancer Therapies
- Heme Oxygenase-1 and Carbon Monoxide
- Long-Term Effects of COVID-19
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Wuhan University
2015-2025
Renmin Hospital of Wuhan University
2015-2025
Creative Commons
2023
University of Alabama at Birmingham
2022
Chinese People's Liberation Army
2015
Wuhan General Hospital of Guangzhou
2015
Abstract Objective: Triple-negative breast cancer (TNBC) involves higher rates of recurrence and distant metastasis. The present study sought to characterize the risk factors for metastasis TNBC. Methods: Surveillance, Epidemiology, End Results (SEER) database was exploited enroll patients diagnosed with TNBC from 2010 2015. eligible were dichotomized into locoregional at time diagnosis. Patients’ demographics tumor features, treatment evaluated identify primary categorical variables...
Abstract Objectives The value of adjuvant radiotherapy for triple‐negative breast cancer (TNBC) has been controversial recently. This study aims to clarify the influence on survival TNBC patients after surgery based a large population analysis. Methods Surveillance, Epidemiology, and End Results (SEER) database was exploited select eligible from 2010 2014. categorical variables were examined by chi‐square tests. Breast cancer‐specific (BCSS) overall (OS) compared among who received or not...
To characterize the risk factors for brain metastasis (BM) at presentation and analyze prognostic patients with small cell lung cancer (SCLC).Patients were recruited from SEER database between 2010 2016. They divided into two groups according to BM status. The incidence trends of SCLC its analyzed by joinpoint software. in identified binary logistic regression models. Cox proportional hazard models.The significantly decreased after 2010. Totally 11,093 collected, including 1717 (15.5%) 9376...
Abstract Background Colorectal cancer (CRC) poses a significant health challenge. This study aims to investigate the prognostic value of regulatory T cell (Treg)‐related gene signature in CRC. Methods We extracted expression and clinical data on CRC from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. module related Treg was identified by weighted co‐expression network analysis (WGCNA). genes were filtered univariate Cox, least absolute shrinkage selection operator...
Intravascular transplantation of human-induced pluripotent stem cells (hiPSCs) demonstrated a significant therapeutic effect in the treatment restenosis by paracrine function extracellular vesicles (EVs). However, risk tumorigenicity and poor cell survival limits its clinical applications. In this study, we for first time applied highly efficient robust three-dimensional (3D) protocol hiPSC differentiation into endothelial (ECs) with subsequent isolation EVs from derived hiPSC-EC (ECs...
High-throughput sequencing has provided unprecedented opportunities to elucidate the role of human gut microbiota. However, current studies have primarily focused on infant and adult cohorts, leaving biomarkers associated with development transitional children unclear, particularly in revealing geographic, multi-ethnic group underrepresented. Here, we analyzed fecal samples from 776 infants aged 0 15 years amplicon 16S rRNA groEL gene, representing groups different residential locations...
Introduction The causal relationship between type 1 diabetes mellitus (T1DM) and osteoporosis has not been clarified in large prospective cohort studies. This study aims to determine the link T1DM osteoporosis, further identify eligible mediators. Material methods We explored by two-sample Mendelian randomization (MR), a method that uses genetic variants as instrumental variables for inference. selected five candidate mediators based on their relevance metabolic processes bone health,...
To investigate the feasibility and safety of peripherally inserted central catheters (PICCs) accessed via superficial femoral vein in patients with superior vena cava syndrome (SVCS).From October 2010 to December 2014, 221 cancer SVCS our center received real-time ultrasound-guidance (FICCs) at mid-thigh. PICC insertion upper extremity veins had also been investigated 2604 without as control. The average catheterization time, one-time puncture frequency, catheter duration complications were...
Objectives: Gastric neuroendocrine carcinoma (GNEC) is a class of rare histological subtypes in gastric cancer (GC). This retrospective case-control study aimed to explore the clinicopathological features and overall survival (OS) patients with GNEC. Methods: A large population GNEC intestinal-type GC (IGC) were extracted from Surveillance, Epidemiology, End Results (SEER) database. The 1:1 propensity score matching (PSM) analysis was initiated adjust confounders between IGC cohorts....
To analyze the therapeutic effect of bevacizumab on radiation-induced brain necrosis. Four necrosis patients, administered with at a dose 7.5 mg/kg every 3 weeks, 2 times. One case metastasis lung cancer and one nasopharyngeal carcinoma after radiotherapy. However, their physical signs disappeared treatment bevacizumab. brainstem lesion glioma patient showed transient improvement in symptoms Bevacizumab can significantly alleviate edema, improve successively.
INTRODUCTION: This study aims to identify the oxidative stress–related genes (OSRGs) with prognostic value and develop a riskscore model for prognosis evaluation in colon cancer. METHODS: The transcriptome data corresponding clinical information about cancer were extracted from Cancer Genome Atlas database. Differentially expressed OSRGs transcription factors (TFs) identified between normal tumor samples. A was established filtered Cox regression analysis. appraised by Kaplan-Meier plot,...
Primary gastric adenosquamous carcinoma (ASC) is an exceedingly rare histological subtype. Gastric signet ring cell (SRC) a unique subtype with distinct tumor biology and clinical features. The prognosis of ASC vs SRC has not been well established to date. We hypothesized that further knowledge about these cancers would improve the management such patients.To investigate clinicopathological characteristics SRC.A cohort cancer patients was retrospectively collected from Surveillance,...
Background: GW843682X is a publicly available anti-cancer compound by inhibiting Polo-like kinase. Previous studies revealed that inhibited the proliferation of various tumor cell lines. In this study, cytotoxic effect was investigated on proliferation, cycle and apoptosis nasopharyngeal carcinoma 5-8F cells. Methods: Cell morphological changes were observed inverted microscopy. tested CCK8 assay. arrest flow cytometry. The mechanism RT-PCR to determine mRNA expression IAP-1, IAP-2, XIAP,...
Objective: To explore the clinical and pathological features of gastric signet ring cell carcinoma, evaluate survival impact preoperative radiotherapy on these patients. Methods: The Surveillance, Epidemiology, End Results database was used to extract eligible patients from 2004 2015. were divided into those with without radiotherapy. categorical variables described by chi-square tests. patients’ compared between 2 groups Kaplan-Meier method log-rank Cox proportional hazard model adopted...
Chemotherapy-induced myelosuppression is one of the main problems in treatment cancer. In present study, effects allogeneic umbilical cord blood hematopoietic stem cell (UCB-HSC) infusion were investigated on chemotherapy-related myelosuppression. total, 65 patients (male, 42; female, 23) diagnosed with included study. The majority classified stage II myelosupression at enrolment, and an average concentration 7.07×109/l UCB-HSCs transfused through peripheral vein. minimum values white (WBC)...
The role of surgery in the treatment patients with distant metastatic (M1) gastric cancer (GC) remains controversial currently. This study aimed to clarify impact primary tumor resection (PTR) on survival such patients.The surveillance, epidemiology, and end results database was adopted extract eligible patients. We designed a retrospective case-control study. were divided into two groups according whether they received PTR. 1:1 propensity score matching (PSM) analysis performed balance...
Myelodysplastic syndromes (MDS) are a group of heterogeneous hematologic malignancies. This study aims to identify latent chromosomal abnormalities relevant MDS, which may optimize the current diagnosis MDS. Affymetrix CytoScan 750 K microarray platform was utilized perform genome-wide detection aberrations in bone marrow cells patients. The findings were compared with results from traditional karyotypic analysis and FISH reveal aberrations. Chromosomal gain, loss, UPD, complex karyotypes...
Esophageal cancer (EC) is a prevalent malignancy with heterogeneous outcomes. This study explores the significance of anoikis-related long non-coding RNAs (lncRNAs) in EC, aiming to unravel their molecular roles and clinical implications.