Introduction Caffeinated chewing gum, known for its rapid absorption, has not been previously studied effects on maximal strength and muscular endurance in resistance exercise. The aim of this study was to determine the efficacy caffeinated gum during bench press back squat exercises. Methods In a randomized, double-blind design, 16 resistance-trained males (age: 21.6 ± 2.0 years, height: 176.8 6.1 cm, mass: 79.6 8.8 kg) chewed either (3 mg/kg) or placebo two occasions, 1 week apart. After...

Abstract Objectives The value of adjuvant radiotherapy for triple‐negative breast cancer (TNBC) has been controversial recently. This study aims to clarify the influence on survival TNBC patients after surgery based a large population analysis. Methods Surveillance, Epidemiology, and End Results (SEER) database was exploited select eligible from 2010 2014. categorical variables were examined by chi‐square tests. Breast cancer‐specific (BCSS) overall (OS) compared among who received or not...

Abstract Background In the development of prediction models for a clinical event, it is common to use static modeling (SPM), regression model that relates baseline predictors time event. many situations, data used in training and validation are from longitudinal studies, where predictor variables time-varying measured at visits. But these not SPM. The landmark analysis (LA), previously proposed dynamic with data, has interpretational difficulty when risk-changing milestone, as often case...

Abstract The density of tumor-infiltrating lymphocytes (TILs) serves as a valuable indicator for predicting anti-tumor responses, but its broad impact across various types cancers remains underexplored. We introduce TILScout, pan-cancer deep-learning approach to compute patch-level TIL scores from whole slide images (WSIs). TILScout achieved accuracies 0.9787 and 0.9628, AUCs 0.9988 0.9934 in classifying WSI patches into three categories—TIL-positive, TIL-negative, other/necrotic—on...

Abstract Background Atrioventricular nodal reentry tachycardia (AVNRT) is the most common type of paroxysmal supraventricular tachycardia, and catheter ablation atrioventricular node slow pathway (AVNSP) standard treatment. However, AVNSP located within Koch triangle, an area with significant anatomical variation. Accurate localization critical for precise implementation ablation, as it directly impacts success safety procedure. Objective To investigate efficacy radiofrequency AVNRT guided...

Substantial progress has been made in the field of large-area land cover mapping as spatial resolution remotely sensed data increases. However, a significant amount human power is still required to label images for training and testing purposes, especially high-resolution (e.g., 3-m) mapping. In this research, we propose solution that can produce 3-m maps on national scale without efforts being involved. First, using public 10-m an imperfect dataset, deep learning based approach effectively...

The hydrological regime in arid and semi-arid regions is quite sensitive to climate land cover changes (LCC). Three-North region (TNR) China experiences diverse conditions, from humid zones. In this region, substantial LCC has occurred over the past decades due ecological restoration programs urban expansion. At a regional scale, effects of have been demonstrated be less observable than change, but it unclear whether or not may intensified by future conditions. study, we employed remote...

Aim: The choice of covariates in unanchored matching-adjusted indirect comparisons (MAICs) single-arm cancer trials with time-to-event outcomes remains a challenge. Currently, there is lack systematic approach for validating the selection bias reduction MAIC. Materials & methods: This study proposes validation framework to evaluate appropriateness selected prognostic factors before their use process involves identifying potential from individual patient data and calculating risk scores...

Phenological mismatches between migratory birds and food availability driven by global warming have been found to influence the fitness population dynamics of several herbivorous goose species in Arctic breeding sites. However, effect phenological at wintering sites inadequately studied. We used long-term data explore consequences water regime changes on mismatch (i.e., days arrival geese timing optimal Normalized Difference Vegetation Index [NDVIopt]) detect relative role as a driver annual...

A parallel volume holographic optical fingerprint recognition system robust to translation, rotation and nonlinear distortion is proposed. The measures the similarity by using filters of multiplexed holograms recorded in media. encoded into multiple template data pages based on local minutiae structure coding method after it adapted for channel. An improved filter recording time schedule a post-filtering calibration technology are combined suppress calculating error from large variations...

Abstract Caisang Lake, a human-modified wetland, experienced dramatic habitat alterations from the planting of lotus and culturing crab. Whether Lake still maintains populations wintering waterbirds is great concern. Here, we compare changes in waterbird before after assess driving factors leading to populations. Results indicate that were significantly impacted by altered forage availability, with species- guild-specific responses. Dramatic caused significant declines areas native...

To improve the robust performance to detect hemorrhage lesions in diabetic retinopathy image, a background estimation and vessel exclusion based algorithm is proposed this paper. Candidate hemorrhages are located by Mahalanobis distance, then on basis of shape analysis, conducted remove non pixels. Experiments results show that our method effective reduce false negative arise from inaccurate structure.

Background The study was conducted to evaluate the feasibility of using malignant pleural effusion (MPE) as a substitute specimen for genetic testing and determine significance profiling MPE tumor cells monitor non‐small cell lung cancer (NSCLC) progression therapeutic response. Methods We selected 168 NSCLC patients with MPE. extracted enriched custom‐designed device. EGFR mutations ALK / ROS1 fusions were then detected by quantitative real‐time PCR, results used guide targeted therapy....

In recent years, knowledge graph completion (KGC) has garnered significant attention. However, noise in the poses numerous challenges to of tasks, including error propagation, missing information, and misleading relations. Many existing KGC methods utilize multi-head self-attention mechanism (MHA) transformers, which yields favorable results low-dimensional space. Nevertheless, employing MHA introduces risk overfitting due a large number additional parameters, choice model loss function is...

Journal Article Patient doses in different projections of conventional diagnostic X-ray examinations Get access Haikuan Liu, Liu Institute Radiation Medicine, Fudan University, 2094 Xietu Road, Shanghai 200032, People's Republic China Search for other works by this author on: Oxford Academic PubMed Google Scholar Weihai Zhuo, Zhuo * *Corresponding author: whzhuo@fudan.edu.cn Bo Chen, Chen Yanling Yi, Yi Dehong Li Protection Dosimetry, Volume 132, Issue 3, December 2008, Pages 334–338,...

Multiple randomized clinical trials have demonstrated that epidermal growth factor receptor (EGFR) exon 19 deletion (19Del) and 21 L858R mutation (L858R) are highly correlated with sensitivity to tyrosine kinase inhibitor (EGFR-TKI) treatment in non-small-cell lung cancer (NSCLC). A 20 (T790M) is reportedly associated resistance EGFR-TKIs. However, few studies focused on patients harboring double mutations these 3 sites. In this retrospective study, forty-five (45/2546, 1.7%) harbored of...