A5102018071- Prosthetics and Rehabilitation Robotics
- Stroke Rehabilitation and Recovery
- Soft Robotics and Applications
- Muscle activation and electromyography studies
- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Microbial Fuel Cells and Bioremediation
- Gastrointestinal motility and disorders
- Tissue Engineering and Regenerative Medicine
- Neuroscience and Neural Engineering
- Cardiomyopathy and Myosin Studies
- Oral microbiology and periodontitis research
- Balance, Gait, and Falls Prevention
- Gut microbiota and health
- Advanced Sensor and Energy Harvesting Materials
- Ergonomics and Musculoskeletal Disorders
- Robotic Locomotion and Control
- Oral and gingival health research
- Robotics and Automated Systems
- Dielectric materials and actuators
- Probiotics and Fermented Foods
- Engineering Applied Research
- SARS-CoV-2 and COVID-19 Research
- Electrospun Nanofibers in Biomedical Applications
Nagasaki University Hospital
2016-2025
Kagawa University
2016-2025
Kobe University
2013-2025
Tokyo Women's Medical University
2011-2024
Hokkaido University
2009-2024
Kyoto University
1990-2024
Klinikum rechts der Isar
2024
Technical University of Munich
2024
Osaka Metropolitan University
2024
Iwate Medical University
2012-2023
Chemical modifications of native proteins can facilitate production supernatural protein functions that are not easily accessible by complementary methods relying on genetic manipulations. However, accomplishing precise control over selectivity while maintaining structural integrity and homogeneity still represents a formidable challenge. Herein, we report transition metal-free method for tryptophan-selective bioconjugation is based an organoradical operates under ambient conditions. This...
In the future, when average age of members society becomes advanced, an innovative technology to assist activities daily living elderly and disabled people in heavy work nursing will be desired. To develop such a technology, actuator that is safe user-friendly required. It should small, lightweight, sufficiently soft. Such available artificial muscle made pneumatic rubber. We have developed some types rubber muscles applied them wearable power devices. A device fitted human body support...
The gut microbiome has emerged as a key regulator of obesity; however, its role in brown adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We found that the levels circulating branched-chain amino acids (BCAA) their cognate α-ketoacids (BCKA) were significantly correlated body weight humans mice BCAA catabolic defects BAT associated diet-induced (DIO) mice. Pharmacological systemic enhancement activity reduced plasma BCKA protected against these effects...
We have developed our original tissue engineering technology “cell sheet engineering” utilizing temperature-responsive culture dishes. The cells are confluently grown on a dish and can be harvested as cell by lowering temperature without enzymatic digestion. Cell sheets high-cell-density tissues similar to actual living tissues, maintaining their structure function. Based this engineering”, we trying create functional cardiac from human induced pluripotent stem cells, for regenerative...
A 2019 nationwide study in Japan revealed the predominant methicillin-resistant Staphylococcus aureus (MRSA) types bloodstream infections (BSIs) to be sequence type (ST)8-carrying SCCmec IV (ST8-MRSA-IV) and clonal complex 1-carrying (CC1-MRSA-IV). However, detailed patient characteristics how these MRSA evolve over time remain largely unknown. In this long-term single-center study, strains isolated from blood cultures at Nagasaki University Hospital 2012 were sequenced analyzed....
At the basis of Frank-Starling mechanism is intrinsic ability cardiac muscle to produce active tension in response stretch. Titin, a giant filamentous molecule involved passive development, intimately associated with thick filament sarcomere. Titin may therefore contribute development by modulating structure when elongated.Rat skinned right ventricular trabeculae were used. Passive at sarcomere length (SL) 2.0 2.4 micrometer was decreased after treatment preparation trypsin (0.25...
Objective. Irritable bowel syndrome is characterized by abdominal discomfort and/or pain associated with altered habits. The neurotransmitter serotonin and type 3 receptors that are extensively distributed on enteric neurons in the human gastrointestinal tract play a role increasing sensation of affecting habits patients irritable syndrome. aim this study was to evaluate efficacy safety receptor antagonist ramosetron hydrochloride Japanese diarrhea-predominant Material methods. In...
The purpose of this study is to develop a soft-material power-assist glove for hand grasping in daily life by older or disabled persons. Such must be compact, lightweight, and flexible. we developed consists rubber cloth, user-friendly. This paper describes the types muscle soft glove, together with control based on human intent effectiveness our proposal.
The accurate diagnosis of individual tooth prognosis has to be determined comprehensively in consideration the broader treatment plan. objective this study was establish an effective artificial intelligence (AI)-based module for decision based on Harvard School Dental Medicine (HSDM) comprehensive planning curriculum (CTPC). 2359 teeth from 94 cases evaluated with 1 5 levels (1-Hopeless, 5-Good condition long term) by two groups (Model-A 16, and Model-B 13 examiners) 17 clinical determining...
The purpose of this study is to develop a wearable power assist device for hand grasping in order support activity daily living (ADL) safely and easily. In paper, the mechanism developed described, then effectiveness discussed experimentally.
In this study, in order to realize an assist of independent life for the elderly or people need care and relieve a physical burden worker, active support splint driven by pneumatic soft actuator (ASSIST) has been developed. ASSIST consists plastic interface with palm arm two rotary-type actuators put both sides appliance. paper, fundamental characteristics is described, then effectiveness experimentally discussed. Finally, operation based on human intention described.
<i>Background:</i> Irritable bowel syndrome (IBS) is a common gastrointestinal disorder. Serotonin type 3 (5-HT<sub>3</sub>) receptor antagonist alosetron hydrochloride indicated for women with chronic, severe diarrhea-predominant IBS who have not responded adequately to conventional therapy. However, whether or the therapeutic efficacy of 5-HT<sub>3</sub> antagonists has gender difference uncertain. <i>Methods:</i> A double-blind,...
Abstract Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall, with a notable prebiotic effect on intestinal microbiota. We previously reported that YM increased Bacteroides thetaiotaomicron abundance in vitro rat faeces fermentation, concluding its effects human colonic microbiota should be investigated. In this study, we show and metabolites using fermentation system. Bacterial 16S rRNA gene sequence analysis showed administration did not change...
Adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), is resistant to treatment. In this study, we examined the effects of a new inhibitor deacetylase enzymes, LBH589, on ATLL cells. LBH589 effectively induced apoptosis in ATLL-related cell lines and primary cells reduced size tumors inoculated SCID mice. Analyses, including DNA microarray, revealed that neither death receptors nor p53 pathways contributed...
We investigated the prevalences and risk factors for peri-implant diseases in Japanese adult dental patients attending a follow-up visit at hospitals or clinics as part of their maintenance program. This cross-sectional multicenter study enrolled with implants who attended regular check-ups periodontal program during period from October 2012 through September 2013. Patients least 3 years loading time were included study. The condition tissue was examined classified into following categories:...
Abstract Background The reliable diagnosis of human T-cell leukemia virus type 1 (HTLV-1) infection is important, particularly as it can be vertically transmitted by breast feeding mothers to their infants. However, current in Japan requires a confirmatory western blot (WB) test after screening/primary testing for HTLV-1 antibodies, but this often gives indeterminate results. Thus, collaborative study evaluated the reliability diagnostic assays infection, including WB-based one, along with...
The development of drug delivery systems for use in the treatment cardiovascular diseases is an area great interest. We report herein on evaluation therapeutic potential a myocardial mitochondria-targeting liposome, multifunctional envelope-type nano device targeting pancreatic β cells (β-MEND) that was previously developed our laboratory. Resveratrol (RES), natural polyphenol compound has cardioprotective effect, encapsulated β-MEND (β-MEND (RES)), and its efficacy evaluated using rat...
Abstract Both natural viral infections and therapeutic interventions using vectors pose significant risks of malignant transformation. Monitoring for clonal expansion infected cells is important detecting cancer. Here we developed a novel method tracking clonality via the detection transgene integration sites. RAISING (Rapid Amplification Integration Sites without Interference by Genomic DNA contamination) sensitive, inexpensive alternative to established methods. Its compatibility with...
As society ages and birth rates fall, the dropping number of caregivers for an increasingly elderly population is expected to become a serious problem, raising need devices assist those having difficulty in leading independent lives. These must be used near or directly on their users, making safety user-friendliness equally important. This raises safe, user-friendly actuators that are compact, lightweight, appropriately soft. The pneumatic rubber artificial muscle meets this requirement. We...
The prevalence of irritable bowel syndrome (IBS) among Japanese patients who visit hospitals departments internal medicine is thought to be high. However, no clear statistical evidence has been provided support such a claim. We tested the hypotheses that IBS in medical outpatients clinics Japan high, and feel more psychosocial stress than without IBS.The subjects this study were 633 visited participating physicians. Patients asked fill version Rome II Modular Questionnaire (RIIMQ) for...