A5034042835- Virus-based gene therapy research
- Breast Cancer Treatment Studies
- CAR-T cell therapy research
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Cancer Research and Treatments
- RNA Research and Splicing
- Estrogen and related hormone effects
- Cancer and Skin Lesions
- Monoclonal and Polyclonal Antibodies Research
- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Cell Adhesion Molecules Research
- Children's Physical and Motor Development
- Cancer Immunotherapy and Biomarkers
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Cells and Metastasis
- Herpesvirus Infections and Treatments
- 14-3-3 protein interactions
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Glutathione Transferases and Polymorphisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Colorectal Cancer Treatments and Studies
Ohu University
2025
Hospital Sarikei
2016-2025
Health Sciences University of Hokkaido
1996-2024
Takara (Japan)
2013-2024
Japan Community Healthcare Organization
2015-2023
Seirei Christopher University
2019-2023
University of Alberta
2023
Nagoya University
2014-2023
Ehime University Hospital
2023
Takara (Sweden)
2014-2022
Prognosis of pancreatic cancer is poor with a 5-year survival rate only 7%. Although several new chemotherapy treatments have shown promising results, all patients will eventually progress, and we need to develop newer improve response rates overall (OS). HF10 spontaneously mutated oncolytic virus derived from herpes simplex virus-1, it has potential show strong antitumor effect against malignancies without damaging normal tissue. We aimed evaluate the safety anti-tumor effectiveness in...
Abstract Purpose: The chemokine CC-ligand 21/secondary lymphoid tissue (CCL21/SLC) regulates the homing of naïve T cells and dendritic that express CC-chemokine receptor 7 (CCR7) from distant sites to such as lymph nodes. We hypothesized CCL21/SLC migration CCR7-bearing melanoma a primary lesion regional tumor-draining Experimental Design: Quantitative real-time reverse transcriptase-PCR (qRT) assay immunohistochemistry (IHC) were used assess level CCR7 expression in cell lines metastatic...
In the present investigation, we generated platelets (PLTs) from cord blood (CB) CD34+ cells using a three‐phase culture system. We first cultured 500 CB on telomerase gene‐transduced human stromal (hTERT stroma) in serum‐free medium supplemented with stem cell factor (SCF), Flt‐3/Flk‐2 ligand (FL), and thrombopoietin (TPO) for 14 days. then transferred to hTERT stroma another days fresh containing interleukin‐11 (IL‐11) addition original cytokine cocktail. Subsequently, liquid SCF, FL, TPO,...
During the typical school day, physical education (PE) gives children an opportunity for activity (PA) and reduces their sedentary time, but little is known about objectively evaluated PA time during PE lessons differences across genders grades. There also a lack of research comparing among different types lessons. The primary aim this study was to examine students' moderate-to-vigorous (MVPA) levels whether there are gender or grade in cross-sectional study. secondary determine which best...
Our purpose was to assess the clinical data, predictors of mortality and acute exacerbation (AE) in combined pulmonary fibrosis emphysema (CPFE) patients.Single-centre retrospective cohort study.Teaching hospital Japan.We identified 93 CPFE patients with high-resolution computed tomographic (HRCT) through multidisciplinary discussion. Patients who had connective tissue disease, drug-associated interstitial lung disease occupationally related such as asbestosis silicosis, were excluded.There...
Breast cancer is one of the most common and feared cancers faced by women. The prognosis patients with advanced or recurrent breast remains poor despite refinements in multimodality therapies involving chemotherapeutic hormonal agents. Multimodal therapy more specific effective strategy urgently needed. oncolytic herpes simplex virus (HSV) has potential to become a new treatment option because its broad host range tumor selective viral distribution. Bevacizumab monoclonal antibody against...
Background and Objective Full‐mouth scaling root planing ( FM ‐ SRP ) acts as a potent inflammatory stimulus immediately after treatment; however, systemic inflammation typically improves in the long term. The contribution of to biological acute‐phase responses is largely unknown. purpose this prospective intervention study was assess local . Material Methods Thirty‐one patients with generalized moderate‐to‐severe chronic periodontitis received 1‐stage Measurement clinical parameters body...
Treatment with an aromatase inhibitor for 5 years is the standard treatment postmenopausal hormone receptor-positive breast cancer. We investigated effects of extending this to 10 on disease-free survival (DFS).This prospective, randomized, multicenter open-label phase III study assessed effect anastrozole additional in patients who were after either alone or 2-3 tamoxifen followed by anastrozole. Patients allocated randomly (1:1) continue stop The primary end point was DFS, including cancer...
The polyphenol (-)-epigallocatechin-3-gallate (EGCG) is a green tea constituent, which has been shown to inhibit cancer cell growth in vitro, vivo and epidemiological studies. In this study, we investigated its effects gastric lines. Five lines, the MKN-1, MKN-28, MKN-45, NUGC-3 TMK-1, were found be sensitive EGCG treatment. Of all lines tested, was most sensitive. treatment of cells induced apoptosis, confirmed by sub-G1 analysis, caspase-Glo assay Western blotting against cleaved PARP...
Abstract Background Penicillium species are among the most common fungi present in environment and usually considered non-pathogenic to humans. However, immunocompromised hosts they can be virulent pathogens cause death. digitatum is a plant pathogen that commonly causes postharvest fungal disease of citrus called green mould; it very rarely systemic mycosis Here, we report case fatal pneumonia due P. infection, as confirmed by repeated examination cultured sputum. Case presentation A cavity...
To assess the outcome of breast papillary lesions diagnosed by ultrasound-guided core needle biopsy (CB) or vacuum-assisted 'mammotome' (MT), accuracy these diagnoses, and whether it is justified not to undertake surgical excision non-malignant so diagnosed.Among 3219 (MT, 2195; CB, 1024) biopsies spanning 5 years, 185 (5.7%) [MT, 162 (88%); 23 (12%)] were identified. Of these, 142 cases (77%; MT/CB, 125/17) benign, 24 (13%, 23/1) atypical, 19 (10%; 14/5) malignant. benign cases, 114 had...
9510 Background: HF10 is a bioselected replication-competent oncolytic virus derived from HSV-1. Herein, we report the safety and efficacy data of + ipilimumab (ipi) combination treatment in Phase II trial melanoma. Methods: Key entry criteria: age ≥ 18 yrs, ECOG ≤ 2, Stage IIIB, IIIC, or IV unresectable melanoma, ipi naïve (IV administration) measurable non-visceral lesion(s) suitable for injection. injected into single multiple tumors (1 x 10 7 TCID 50 /mL/dose, up to 5mL depending on...
We investigated the prevalences and risk factors for peri-implant diseases in Japanese adult dental patients attending a follow-up visit at hospitals or clinics as part of their maintenance program. This cross-sectional multicenter study enrolled with implants who attended regular check-ups periodontal program during period from October 2012 through September 2013. Patients least 3 years loading time were included study. The condition tissue was examined classified into following categories:...
Abstract Nuclear expression of Y-box–binding protein (YBX1) is closely correlated with clinical poor outcomes and drug resistance in breast cancer. translocation YBX1 facilitated by phosphorylation at serine 102 AKT, p70S6K, p90RSK, the phosphorylated (pYBX1) promotes genes related to cell growth. A forthcoming problem be addressed whether targeting overcomes antiestrogen progressive Here, we found that increased pYBX1 was accompanied acquired antiestrogens, fulvestrant tamoxifen. Forced...
Oncolytic viruses (OVs) can selectively replicate in tumor cells and remodel the microenvironment of immunologically cold tumors, making them a promising strategy to evoke antitumor immunity. Similarly, agonists stimulator interferon genes (STING)-interferon (IFN) pathway, main cellular antiviral system, provide benefits by inducing activation dendritic (DC). Considering how STING-IFN pathway could potentially inhibit OV replication, use STING alongside therapy remains largely unexplored....