A5012574298- CAR-T cell therapy research
- Cutaneous Melanoma Detection and Management
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Nonmelanoma Skin Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Melanoma and MAPK Pathways
- Reconstructive Facial Surgery Techniques
- Hedgehog Signaling Pathway Studies
- Virus-based gene therapy research
- Wound Healing and Treatments
- Surgical Sutures and Adhesives
- Cutaneous lymphoproliferative disorders research
- Viral Infectious Diseases and Gene Expression in Insects
- Sarcoma Diagnosis and Treatment
- Optical Coherence Tomography Applications
- Tumors and Oncological Cases
- Infectious Diseases and Mycology
- Digital Imaging in Medicine
- Cancer Genomics and Diagnostics
- Genetic and rare skin diseases.
- Cancer and Skin Lesions
- Polyomavirus and related diseases
- Cell Image Analysis Techniques
- Breast Implant and Reconstruction
Pennsylvania State University
2012-2024
Penn State Milton S. Hershey Medical Center
2013-2023
Moffitt Cancer Center
2021-2023
Winship Cancer Institute
2022
Vassar Brothers Medical Center
2022
Indra (Spain)
2021
Creative Commons
2019
Hershey (United States)
1996-2017
Skin Cancer Foundation
2017
Heinrich Heine University Düsseldorf
2015
Sentinel-lymph-node biopsy is associated with increased melanoma-specific survival (i.e., until death from melanoma) among patients node-positive intermediate-thickness melanomas (1.2 to 3.5 mm). The value of completion lymph-node dissection for sentinel-node metastases not clear.
There is a growing body of evidence supporting the synergistic roles radiotherapy and immunotherapy in treatment malignancy. Published case studies abscopal effect have been reported with use ipilimumab metastatic melanoma, but routine this combination therapy limited. We conducted retrospective analysis to evaluate patients treated for advanced melanoma at single institution from May 2011 June 2015. Patients were grouped into those who had received concurrent while on (Ipi-RT), did not....
Circulating tumor cells (CTCs) are of recognized importance for diagnosis and prognosis cancer patients. With melanoma, most studies do not show any clear relationship between CTC levels stage disease. Here, CTCs were enriched (∼400X) from blood melanoma patients using a simple centrifugation device (OncoQuick), 4 melanocyte target RNAs (TYR, MLANA, MITF, MIF) quantified QPCR. Approximately one-third had elevated MIF MLANA transcripts (p<0.0001 p<0.001, respectively) compared with healthy...
Background While the morbidity and mortality from cancer are largely attributable to its metastatic dissemination, integral features of cascade not well understood. The widely accepted hypothesis is that primary tumor microenvironment induces epithelial-to-mesenchymal transition in cells, facilitating their escape into bloodstream, possibly accompanied by stem cells. An alternative theory for metastasis involves fusion macrophages with cells (MTFs). Here we culture characterize apparent MTFs...
Acellular dermal matrix (ADM) is frequently used in tissue expander breast reconstruction (TEBR) for coverage of the inferior pole. Several published studies have suggested increased rates complications with use ADM. It unknown, however, if type ADM TEBR impacts complication rates. The aim this study to compare 3 different types regard clinically significant complications, specifically infection. We performed a retrospective analysis primary cancer-related or without Exclusion criteria...
<h3>Importance</h3> Sentinel lymph node (SLN) biopsy is a standard staging procedure for cutaneous melanoma. Regional disease control clinically important therapeutic goal of surgical intervention, including nodal surgery. <h3>Objective</h3> To determine how frequently SLN without completion dissection (CLND) results in long-term regional patients with metastases. <h3>Design, Setting, and Participants</h3> The second Multicenter Selective Lymphadenectomy Trial (MSLT-II), prospective...
The current treatment of extremity sarcomas is multimodal, consisting limb-sparing surgery, adjuvant radiotherapy, and/or chemotherapy. This approach has decreased the need for amputations and increased demand coverage large composite defects. To date, role microsurgery in lower reconstruction after oncologic resection not been well defined. study reviews a single center's experience with free tissue transfer resection. Fifty-nine flaps were performed 57 patients over 5-year period....
To report a single-institution experience in the treatment of cutaneous head and neck angiosarcoma.Case series.Twenty-three patients were evaluated: 12 females 11 males. The primary site lesion was 9 patients, scalp 9, face 5. No patient had been submitted to previous but 10 incisional biopsy. lesions' size ranged from 2.5 cm (median 4 cm).All one surgical resection as treatment. Twenty-two received adjuvant treatment: 8 cases local recurrence distant metastasis. Two presented synchronous...
With a rise in tissue expander-based breast reconstructions (TEBRs) using acellular dermal matrix (ADM), we have seen an increase ADM-specific complications. In this study, aimed to evaluate clinically significant seroma (CSS) formation-defined by the need for drainage procedure-to determine if there was difference incidence between product types: AlloDerm (AL), DermaMatrix (DM), and FlexHD (FHD). This retrospective review of consecutive patients who underwent TEBR at single institution. The...
9510 Background: HF10 is a bioselected replication-competent oncolytic virus derived from HSV-1. Herein, we report the safety and efficacy data of + ipilimumab (ipi) combination treatment in Phase II trial melanoma. Methods: Key entry criteria: age ≥ 18 yrs, ECOG ≤ 2, Stage IIIB, IIIC, or IV unresectable melanoma, ipi naïve (IV administration) measurable non-visceral lesion(s) suitable for injection. injected into single multiple tumors (1 x 10 7 TCID 50 /mL/dose, up to 5mL depending on...
BackgroundMetastatic basal cell carcinoma (mBCC) is a rare condition with no effective second-line treatment options. Cemiplimab an immune checkpoint inhibitor that blocks binding of programmed death-1 (PD-1) to its ligands, PD-L1 and PD-L2. Here, we present the final analysis cemiplimab in patients mBCC after first-line hedgehog pathway inhibitors (HHIs) (NCT03132636).Patients methodsIn this open-label, single-arm, phase II study, adults Eastern Cooperative Oncology Group performance status...
BRAF is the most mutated gene in melanoma, with approximately 50% of patients containing V600E mutant protein. (V600E)B-RAF can be targeted using pharmacological agents, but resistance develops by activating other proteins signaling pathway. Identifying downstream members this cascade important to design strategies avoid development resistance. Unfortunately, remain identified and therapeutic potential requires validation. A kinase screen was undertaken identify targets cascade. Involvement...
One hundred three patients underwent abdominoplasty combined with other intraabdominal procedures including 67 tubal ligations, 34 total abdominal hysterectomies and 2 cholecystectomies, from January 1983 to July 1991. The were divided into two groups, those undergoing the standard or limited without liposuction in delimited areas. In this series of 103 patients, we found only minor complications transfused autologous units blood. When performed by well-schooled surgical teams, may be...
We report 3 cases of durable complete response (CR) in patients with BRAF-mutated metastatic melanoma who were initially treated unsuccessfully sequential immunotherapies (high dose interleukin 2 followed by ipilimumab or without concurrent radiation therapy). After progression during post immunotherapy, these given BRAF inhibitor therapy and developed rapid CRs. Based on the concomitant presence autoimmune manifestations (including vitiligo hypophysitis), we postulated that there was a...
Abstract Purpose: Neoadjuvant immunotherapy may improve the clinical outcome of regionally advanced operable melanoma and allows for rapid pathologic assessment response. We examined neoadjuvant pembrolizumab high-dose IFNα-2b (HDI) therapy in patients with resectable melanoma. Patients Methods: stage III/IV were treated concurrent 200 mg i.v. every 3 weeks HDI 20 MU/m2/day i.v., 5 days per week 4 weeks, then 10 subcutaneously 2 weeks. Definitive surgery followed, as did adjuvant combination...
In patients who undergo oral cavity reconstruction, loss of sensation plays a vital role in producing disturbances postoperative function. Microsurgical techniques have provided method addressing this deficit through the use sensate cutaneous free flaps which microneural anastomoses are performed between sensory nerve supplying flap, and recipient head neck. The purpose study was to compare radial forearm flap lateral arm donor sites, two most commonly used intraoral flaps. For comparison,...
A incidência do melanoma cutâneo tem aumentado mundialmente e, por tratar-se de neoplasia bastante agressiva e difícil tratamento em estádios mais avançados, o diagnóstico precoce é fundamental para a cura paciente. dermatoscopia surgiu como exame auxiliar in vivo, que papel na realização amplifica acurácia diagnóstica melanoma. Para método, necessário utilizar dermatoscópio, aparato permite aumentar lesão, no mínimo, 10 vezes. imagem obtida interpretada utilizando-se método da preferência...