A5067129653- Breast Implant and Reconstruction
- Cutaneous Melanoma Detection and Management
- Breast Cancer Treatment Studies
- Cell Adhesion Molecules Research
- Reconstructive Surgery and Microvascular Techniques
- Protease and Inhibitor Mechanisms
- Nonmelanoma Skin Cancer Studies
- Cancer survivorship and care
- Cellular Mechanics and Interactions
- Melanoma and MAPK Pathways
- Body Contouring and Surgery
- Wound Healing and Treatments
- Breast Lesions and Carcinomas
- Hernia repair and management
- Periodontal Regeneration and Treatments
- Nail Diseases and Treatments
- Global Cancer Incidence and Screening
- Lymphatic System and Diseases
- Pregnancy-related medical research
- Economic and Financial Impacts of Cancer
- Cancer and Skin Lesions
- TGF-β signaling in diseases
- Bone and Dental Protein Studies
- BRCA gene mutations in cancer
- Immunotherapy and Immune Responses
University of Helsinki
2011-2025
Helsinki University Hospital
2014-2025
Jorvi Hospital
2014
Töölö Hospital
2011-2013
Texas Plastic Surgery
2006-2012
Hospital District of Helsinki and Uusimaa
2010
Lund University
2002
Bispebjerg Hospital
2002
Sentinel-lymph-node biopsy is associated with increased melanoma-specific survival (i.e., until death from melanoma) among patients node-positive intermediate-thickness melanomas (1.2 to 3.5 mm). The value of completion lymph-node dissection for sentinel-node metastases not clear.
<h3>Importance</h3> Sentinel lymph node (SLN) biopsy is a standard staging procedure for cutaneous melanoma. Regional disease control clinically important therapeutic goal of surgical intervention, including nodal surgery. <h3>Objective</h3> To determine how frequently SLN without completion dissection (CLND) results in long-term regional patients with metastases. <h3>Design, Setting, and Participants</h3> The second Multicenter Selective Lymphadenectomy Trial (MSLT-II), prospective...
Wound healing involves highly controlled events including reepithelialization, neoangiogenesis, and reformation of the stromal compartment. Matrix metalloproteinases (MMPs) are a family neutral zinc-dependent endopeptidases known to be essential for wound-healing process. MMP-8 (collagenase-2) is neutrophil-derived effective type I collagenase, recently indicated important acute wound healing. MMP-26 more recent less well-studied member MMP family. Our aim was study expression in human...
Skin-sparing mastectomy (SSM) facilitates optimal immediate breast reconstruction (IBR) by preserving the inframammary fold and most of skin. Concerns persist that SSM might increase rate local recurrence as surgical approach is less extensive. Patients who had IBR over 10 years at a single institution were reviewed.A total 207 consecutive women underwent from 1992 to 2001 included in study. The patient records analysed retrospectively follow-up data included.Postoperative complications...
Background: The prognosis of breast cancer has improved significantly during the last few decades increasing interest in health-related quality life (HRQoL). aim this study was to compare HRQoL scores produced by different instruments and shed light on their validity various states studying association cancer-related symptoms with HRQoL.Material methods: An observational, cross-sectional patients treated Helsinki Uusimaa Hospital District from September 2009 April 2011. A total 840 completed...
In monogenic autoinflammatory diseases, mutations in genes regulating innate immune responses often lead to uncontrolled activation of inflammasome pathways or the type I interferon (IFN-I) response. We describe a mechanism autoinflammation potentially predisposing patients life-threatening necrotizing soft tissue inflammation. Six unrelated families are identified which affected members present with fasciitis severe inflammations. Exome sequencing reveals truncating monoallelic...
// Johanna Eriksson 1 , Vadim Le Joncour 2 Pirjo Nummela Tiina Jahkola 3 Susanna Virolainen Laakkonen Olli Saksela 4 Erkki Hölttä Department of Pathology, University Helsinki, FI-00014 Finland Research Programs Unit, Translational Cancer Biology, Biomedicum Plastic Surgery, Helsinki Central Hospital, FI-00029 Dermatology, Correspondence to: Hölttä, e-mail: erkki.holtta@helsinki.fi Keywords: melanoma, invasion/metastasis, CTHRC1, NFATC2, TGFβ Received: June 11, 2015 Accepted: January 31, 2016...
Abstract MMP‐19 (also designated RASI) is a recently discovered member of large family zinc‐dependent proteolytic enzymes, most which have been implicated in cancer growth and metastasis. It differs from the others by its chromosomal location structure expressed endothelial vascular smooth muscle cells vivo. Our aim was to study putative role skin cancer. We also examined regulation keratinocyte cultures using quantitative TaqMan RT‐PCR. results show that can be detected stimulated...
Tenascin (Tn) is an extracellular matrix glycoprotein transiently expressed in epithelial-mesenchymal interaction areas during embryogenesis. Tn a limited manner adult tissues but emerges wound healing and tumorigenesis. We have studied expression by immunohistochemistry 137 small node-negative breast cancers treated with breast-conserving surgery post-operative radiotherapy 1985–1996. None of the patients had undergone any adjuvant hormonal therapy or chemotherapy. Stromal itself could not...
Abstract Malignant melanomas are characterized by their high propensity to invade and metastasize, but the molecular mechanisms of these traits have remained elusive. Our DNA microarray analyses benign nevi melanoma tissue specimens revealed that genes encoding extracellular matrix proteins tenascin‐C (TN‐C), fibronectin (FN), procollagen‐I (PCOL‐I) highly upregulated in invasive metastatic melanomas. The expression distribution were further studied immunohistochemistry nevi, radially...
Abstract Background Analysing the results of breast reconstruction is important both in terms oncological safety and health‐related quality life (HRQoL). Immediate (IBR) thought to be prone complications heavy for patients with no time adapt having cancer. Delayed (DR) an option after primary surgery treatments, but requires go through two recovery periods surgery. Methods A prospective study 1065 cancer repeated measurement HRQoL generic (15D) disease specific (EORTC QLQ C‐30 BR23)...
Background and purpose: After reports that complete lymph node dissection (CLND) did not improve melanoma-specific survival of sentinel (SLN)-positive patients, the use CLND has diminished but it is still carried out for selected patients. We sought to assess differences in Health-Related Quality Life (HRQoL) tertiary care costs among Finnish Multicenter Selective Lymphadenectomy Trial (MSLT)-II-patients. Patients/materials methods: A total 52 patients randomized 55 nodal observation...
Overexpression of osteopontin (OPN) is strongly associated with the invasiveness/metastasis many cancers, including melanomas. However, molecular mechanisms OPN in these processes remain poorly understood. We found that forced expression early vertical-growth-phase melanoma cells dramatically increased their migration/invasion and growth/survival a three-dimensional collagen I gel. Neutralizing antibodies to OPN, integrin β1, αvβ3, but not CD44, negated effects OPN. Conversely, knocking down...