Hugo Fontan Köhler

ORCID: 0000-0003-2319-7574
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About
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Research Areas
  • Head and Neck Cancer Studies
  • Thyroid and Parathyroid Surgery
  • Head and Neck Surgical Oncology
  • Thyroid Cancer Diagnosis and Treatment
  • Salivary Gland Tumors Diagnosis and Treatment
  • Reconstructive Surgery and Microvascular Techniques
  • Ear and Head Tumors
  • Cancer Diagnosis and Treatment
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Voice and Speech Disorders
  • Airway Management and Intubation Techniques
  • Tracheal and airway disorders
  • Cancer-related molecular mechanisms research
  • Lung Cancer Treatments and Mutations
  • Vitamin D Research Studies
  • Cardiac, Anesthesia and Surgical Outcomes
  • Oral and Maxillofacial Pathology
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Reconstructive Facial Surgery Techniques
  • Parathyroid Disorders and Treatments
  • Renal function and acid-base balance
  • German Social Sciences and History
  • Renal cell carcinoma treatment
  • Head and Neck Anomalies
  • Renal and Vascular Pathologies

AC Camargo Hospital
2014-2025

Hospital São Paulo
2023

Universidade Estadual de Campinas (UNICAMP)
2010-2011

Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
1974-2008

Johannes Gutenberg University Mainz
1993

To evaluate the long-term quality of life patients treated for head and neck cancer at a single institution in developing country.Cross-sectional analysis consecutive series patients.Tertiary center hospital Brazil.Eligible subjects included between 1974 1999 carcinoma who had minimum disease-free survival 2 years completed Portuguese version University Washington Quality Life (UW-QOL) questionnaire.Descriptive analyses results comparisons scores each UW-QOL domain, stratified by tumor site,...

10.1001/archotol.130.10.1209 article EN Archives of Otolaryngology - Head and Neck Surgery 2004-10-01

Objective. The incidence of papillary thyroid carcinoma (PTC) has increased in recent years and its treatment remains controversial. objective this study is to identify clinicopathological predictive factors tumour recurrence.Methods. We retrospectively analysed 4,085 patients who underwent thyroidectomy for PTC from 1996 2015. Patients were stratified according American Thyroid Association (ATA) risk categories features evaluated independent recurrence.Results. After a mean follow-up 58.7...

10.14639/0392-100x-n1412 article EN cc-by-nc-nd Acta Otorhinolaryngologica Italica 2021-06-01

BACKGROUND Up to half of patients with oral cavity squamous cell carcinoma (OCSCC) have stage I II disease. When adequate resection is attained, no further treatment needed; however, re‐resection or radiotherapy may be indicated for positive close margins. This multicenter study evaluated the outcomes and role adjuvant in OCSCC. METHODS Overall survival (OS), disease‐specific survival, local‐free disease‐free rates were calculated Kaplan‐Meier analysis. RESULTS Of 1257 T1‐2N0M0 disease, 33...

10.1002/cncr.31531 article EN Cancer 2018-05-14

BACKGROUND A study was conducted to assess for prognostic heterogeneity within the N2b and N2c classifications oral cancer based on number of metastatic lymph nodes determine whether laterality neck disease provides additional information. METHODS An international multicenter 3704 patients with undergoing surgery curative intent performed. The endpoints interest were disease‐specific survival overall survival. Model fit assessed by Akaike Information Criterion comparison models without...

10.1002/cncr.28686 article EN Cancer 2014-04-01

Abstract Background We aimed to investigate whether depth of invasion (DOI) should be an independent indication for postoperative radiotherapy (PORT) in small oral squamous cell carcinomas (SCC). Methods Retrospective analysis DOI (<5, 5 <10, ≥10 mm) and disease‐specific survival (DSS) a multi‐institutional international cohort 1409 patients with SCC ≤4 cm size treated between 1990‐2011. Results In without other adverse factors (nodal metastases; close [<5 mm] or involved margins),...

10.1002/hed.25633 article EN Head & Neck 2019-02-24

To report a single-institution experience in the treatment of cutaneous head and neck angiosarcoma.Case series.Twenty-three patients were evaluated: 12 females 11 males. The primary site lesion was 9 patients, scalp 9, face 5. No patient had been submitted to previous but 10 incisional biopsy. lesions' size ranged from 2.5 cm (median 4 cm).All one surgical resection as treatment. Twenty-two received adjuvant treatment: 8 cases local recurrence distant metastasis. Two presented synchronous...

10.1016/j.otohns.2008.07.022 article EN Otolaryngology 2008-09-25

Abstract Introduction Postoperative neck hematoma (PNH) is an uncommon but potentially-lethal complication of thyroid surgery. Objective To identify the risk factors for postthyroidectomy requiring reoperation, timing, source bleeding, related respiratory distress tracheotomy, and late outcomes. Methods We retrospectively analyzed records 5,900 consecutive patients submitted to surgery diseases at a single institution. Results In total, PNH occurred in 62 (1.1%) patients. Most cases bleeding...

10.1055/s-0040-1714129 article EN cc-by-nc-nd International Archives of Otorhinolaryngology 2020-09-30

The relationship between preoperative vitamin D deficiency and postoperative hypocalcemia in cases of total thyroidectomy (TT) is a matter controversy may vary according to geographical scenarios populations.The objective here was evaluate whether associated with symptomatic population South America.Retrospective cohort study on data from all patients undergoing thyroidectomy, or without central compartment lymph node dissection, January 2014 December 2017, at the A. C. Camargo Cancer...

10.1590/1516-3180.2018.0336140319 article EN cc-by Sao Paulo Medical Journal 2019-05-01

Neck staging in oral cancer depends on the number of compromised nodes, their size and side occurrence.This paper aims to evaluate risk factors for metastatic nodes levels IV/V prognostic impact patients with carcinoma.Retrospective study.pathologist's diagnosis squamous cell carcinoma, primary tumor lower cavity, no extension into extraoral sites, previous treatment, synchronous neck dissection presence nodes. Risk metastasis were evaluated through logistic regression disease-specific...

10.5935/1808-8694.20120027 article EN cc-by Brazilian Journal of Otorhinolaryngology 2012-11-01

<h3>Importance</h3> Squamous cell carcinoma of the oral cavity (OSCC) is a common malignant tumor worldwide. <h3>Objective</h3> To determine if regional failure in patients with OSCC and pathologically negative neck nodes (pN–) due to an incomplete sampling procedure during surgery. <h3>Design, Setting, Participants</h3> We retrospectively reviewed medical records 2258 from 11 cancer centers worldwide who underwent dissection for (1990-2011) were pN−. Of those, 345 had clinical evidence...

10.1001/jamaoto.2014.1539 article EN JAMA Otolaryngology–Head & Neck Surgery 2014-07-29

To evaluate margins for oral carcinoma according to types of invasion front.Retrospective cohort 772 patients with worst pattern (WPOI) graded 1-5. Local recurrence was the outcome interest.Local recurrences occurred in 164 (21.2%) and affected by WPOI type 4/5, margin distance, perineural invasion, adjuvant radiotherapy. In 1/2/3, a cutoff 1.7 mm considered ideal extent 7.8 mm. Patients below these thresholds had significantly higher incidence local recurrence.Different determine surgical...

10.1002/hed.26956 article EN Head & Neck 2021-12-14

Abstract Background. Paragangliomas of the carotid bifurcation are rare and usually benign neoplasms arising from body chemoreceptors. The aim this retrospective study was to report long‐term results paragangliomas treated in a single institution over period 20 years. following variables described: age, sex, localization, diagnostic workup, operative procedure, complications, proportion characteristics malignant tumors, cure rates. Methods. Thirty‐six patients,10 men 26 women, were treated....

10.1002/hed.20105 article EN Head & Neck 2004-09-30

Objective: Despite a favorable prognosis, some patients with papillary thyroid carcinoma (PTC) develop recurrence. The objective of this study was to examine the impact combination initial American Thyroid Association (ATA) risk stratification serum level postoperative stimulated thyroglobulin (s-Tg) in predicting recurrence PTC and compare results an assessment response therapy (dynamic stratification). Subjects methods: We retrospectively analyzed 1,611 who had undergone total...

10.20945/2359-4292-2022-0506 article EN cc-by Archives of Endocrinology and Metabolism 2024-01-01

Diagnostic confirmation and staging of cancer are primary steps in patients care. Since its inception, the TNM system has as main focus on an essentially anatomic classification associated with survival endpoints. Ideally, it would allow stratification risk groups that have clearly distinct outcomes based some nonanatomic variables but similar within each stratum.

10.21037/cco.2019.03.01 article EN Chinese Clinical Oncology 2019-04-03

10.1007/s00405-009-1144-z article EN European Archives of Oto-Rhino-Laryngology 2009-11-10

To evaluate the role of pre-treatment with dietary antioxidants in an experimental model intestinal injury ischemia-reperfusion (I/R) rats.Ninety adult male Wistar rats were used. An segment was isolated based on its vascular pedicle. A control biopsy performed and pedicle sectioned sutured again, ensuring a time 60 minutes ischemia followed by reperfusion. Sequential biopsies at end ischemic period every 15 during The treatment consisted saline, vitamin C, E or combination latter two....

10.1590/s0100-69912011000600010 article EN cc-by Revista do Colégio Brasileiro de Cirurgiões 2011-12-01

Introduction The incidence of papillary thyroid microcarcinoma (PTMC) has increased, and its treatment remains controversial. Objective To identify the clinical pathological factors predictive tumor recurrence. Methods We retrospectively analyzed 2,538 consecutive patients treated for PTMC, most submitted to total thyroidectomy (98%) followed by radioactive iodine (RAI) ablation (51.7%) at a cancer center from 1996 2015. were stratified according American Thyroid Association (ATA) risk...

10.1055/s-0040-1722253 article EN cc-by-nc-nd International Archives of Otorhinolaryngology 2021-02-19

Objective We investigated motivation levels across the general Brazilian population and subgroups their willingness to spend for surgery without a cervical scar. Methods This random‐sample survey was performed by specialized third‐party research institute. In this study, we created hypothetical thyroidectomy scenario, transcervical transoral endoscopic vestibular approach (TOETVA) were used. The included sociocultural data questions regarding participants' surgical preferences. Results Data...

10.1002/lary.31372 article EN The Laryngoscope 2024-02-27
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