A5047863004- Oral and Maxillofacial Pathology
- Cutaneous Melanoma Detection and Management
- Head and Neck Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Sarcoma Diagnosis and Treatment
- Oral and gingival health research
- Head and Neck Surgical Oncology
- Nonmelanoma Skin Cancer Studies
- Ear and Head Tumors
- Nutrition, Genetics, and Disease
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Oral Health Pathology and Treatment
- Cutaneous lymphoproliferative disorders research
- Vascular Tumors and Angiosarcomas
- Optical Coherence Tomography Applications
- Autoimmune Bullous Skin Diseases
- Bone Tissue Engineering Materials
- Cancer-related gene regulation
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
AC Camargo Hospital
2016-2025
Faculdade de Medicina de Jundiaí
2013-2025
Weatherford College
2021
Instituto de Patologia da Coluna
2018
Faculdade de Medicina do ABC
2018
Universidade Estadual Paulista (Unesp)
2015
Universidade Federal de São Paulo
2015
Hospital São Paulo
2003-2013
Universidade de São Paulo
2003-2012
Centro Universitário de Volta Redonda
2012
Lesions with bone loss may require autologous grafts, which are considered the gold standard; however, natural or synthetic biomaterials alternatives that can be used in clinical situations support for neoformation. Collagen and hydroxyapatite have been repair based on concept of biomimetics, combined chitosan, forming a scaffold cell adhesion growth. However, osteoporosis caused by gonadal hormone deficiency thus compromise expected results osseointegration scaffolds. The aim this study was...
Gold standard treatment for invasive penile carcinoma remains amputation and lymphadenectomy. This procedure has high morbidity new prognostic factors on the incidence of metastasis would help select candidates to Mutations in p53 gene common several neoplasms can be related prognosis. We studied 82 patients with staged according 1978 TNM system who underwent bilateral lymphadenectomy evaluate value immunohistochemical staining primary tumor.Immunoreactivity was other clinicopathological...
Papillary thyroid carcinoma (PTC) is a common endocrine neoplasm with recent increase in incidence many countries. Although PTC has been explored by gene expression and DNA methylation studies, the regulatory mechanisms of on was poorly clarified. In this study, profile (Illumina HumanMethylation 450K) 41 paired non-neoplastic adjacent tissues (NT) carried out to identify contribute elucidation role novel genic intergenic regions beyond those described promoter CpG islands (CGI). An...
Even though the majority of well-differentiated thyroid carcinoma (WDTC) is indolent, a number cases display an aggressive behavior. Cumulative evidence suggests that deregulation DNA methylation has potential to point out molecular markers associated with worse prognosis. To identify prognostic epigenetic signature in cancer. Genome-wide assays (450k platform, Illumina) were performed cohort 50 nonneoplastic tissues (NTs), 17 benign lesions (BTLs), and 74 carcinomas (60 papillary, 8...
ABSTRACT Background The presence of regional lymph node metastasis has an important impact on clinical management and prognostication patients with oral tongue squamous cell carcinoma (SCC). Approximately 30% to 50% SCC have at diagnosis, but the limited sensibility current diagnostic methods used for neck staging does not allow detection all cases, leaving a significant number undiagnosed (occult metastasis). In this study, we evaluated whether clinicopathologic features immunohistochemical...
Histopathologic interpretation of dermoscopic and reflectance confocal microscopy (RCM) features cutaneous melanoma was timidly carried out using perpendicular histologic sections, which does not mimic the same plane image achieved at both techniques (horizontal plane). The aim this study to describe transverse sections research technique correlate main characteristic (atypical network, irregular globules pseudopods) with RCM histopathology in order offer a more precise vivo detectable...
Thyroid nodules are common in adult population and papillary thyroid carcinoma (PTC) is the most frequent malignant finding. The natural history of PTC remains poorly understood current diagnostic methods limitations responsible for a significant number potentially avoidable surgeries. This study aimed to identify molecular markers improve diagnosis lesions. Gene expression profiling was performed using microarray 61 13 surrounding normal tissues (NT). A reliable gene list established...
Biomaterials are used as a promising alternative to bone grafts, including bioceramics whose composition resembles that of and fibrin sealants due their hemostatic properties. The objective was evaluate the repair cranial defects in 40 rats, grafted with hydroxyapatite new sealant derived from snake venom. animals were divided into four groups: C (control, no graft); Ha (hydroxyapatite); FS (fibrin sealant), HaFS (hydroxyapatite sealant). euthanized 2 6 weeks after surgery wound area...
Annexin A1 (AnxA1) is highly secreted by neutrophils and binds to formyl peptide receptors (FPRs) trigger anti-inflammatory effects efferocytosis. AnxA1 also expressed in the tumor microenvironment, being mainly attributed cancer cells. As recruited are player cells at sites, role of neutrophil-derived lung melanoma metastasis was investigated here. Melanoma expressing were detected biopsies from primary patients, which presented higher levels serum augmented neutrophil-lymphocyte ratio...
To analyze the prognostic effect of epidermal growth factor receptor (EGFR), matrix metalloproteinases 2 and 9, vascular endothelial expression in patients with locally recurrent oral carcinoma after salvage surgery.Retrospective cohort study. Settings Tertiary center cancer hospital.The charts 111 local recurrence carcinomas were retrospectively analyzed. The previous treatment consisted surgery 33 (30.0%), radiotherapy or without chemotherapy 46 (41.0%), adjuvant 32 (29.0%). EGFR, was...
Genome-wide profiling of rare tumors is crucial for improvement diagnosis, treatment, and, consequently, achieving better outcomes. Desmoplastic small round cell tumor (DSRCT) a type sarcoma arising from mesenchymal cells abdominal peritoneum that usually develops in male adolescents and young adults. A specific translocation, t(11;22)(p13;q12), resulting EWS WT1 gene fusion the only recurrent molecular hallmark no other genetic factor has been associated to this aggressive tumor. Here, we...
Abstract Background Human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) is associated with better tumor‐response rates and survival outcomes. However, in some geographic regions, the impact of HPV infection on prognosis remains unclear. The aim this study was to describe patterns recurrence among patients treated for OPSCC a region reported low prevalence HPV‐related OPSCC. Methods We retrospectively evaluated 215 diagnosed American Joint Committee Cancer (AJCC)...
Background: Oral tongue squamous cell carcinoma (OTSCC) causes over 350,000 cases annually and particularly impacts populations in developing countries. Smoking alcohol consumption are major risk factors. Determining the role of tumor immune microenvironment (TIME) OTSCC outcomes can elucidate mechanisms behind disease progression, potentially identify prognostic biomarkers. Methods: We performed a retrospective study 48 surgical specimens from patients with tobacco exposures. A panel...
The impact of rapid on-site evaluation (ROSE) on thyroid aspirates has been a matter extensive debate. In the current study, authors reviewed all fine-needle aspiration biopsies (FNABs) performed in their service recent years to evaluate ROSE final adequacy and diagnostic rates.All ultrasound-guided FNABs between July 2015 2017 were included retrospectively. was by experienced cytopathologists, with production Romanowsky-stained slides for immediate evaluation. When not performed, total 3...
DNA methylation in miRNA genes has been reported as a mechanism that may cause dysregulation of mature miRNAs and consequently impact the gene expression. This is largely unstudied papillary thyroid carcinomas (PTC). To identify differentially methylated miRNA-encoding genes, we performed global analysis (Illumina 450 K), integrative (TCGA database), data confirmation (pyrosequencing RT-qPCR), functional assays. Methylation revealed 27 genes. The analyses pointed out miR-21 miR-146b...