A5071164511- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Cancer Immunotherapy and Biomarkers
- Thyroid Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Glycosylation and Glycoproteins Research
- Pleural and Pulmonary Diseases
- Breast Lesions and Carcinomas
- Advanced Breast Cancer Therapies
- Head and Neck Anomalies
- Thyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Salivary Gland Tumors Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
- Mycobacterium research and diagnosis
- Occupational and environmental lung diseases
- Cholinesterase and Neurodegenerative Diseases
- HER2/EGFR in Cancer Research
- bioluminescence and chemiluminescence research
- Cancer Treatment and Pharmacology
- Cancer Cells and Metastasis
Hospital Sírio-Libanês
2021-2025
Dana-Farber Cancer Institute
2020-2025
Dana-Farber Brigham Cancer Center
2020-2024
Brigham and Women's Hospital
2020-2023
Harvard University
2021-2022
Hospital São Paulo
2021
AC Camargo Hospital
2017-2020
Massachusetts General Hospital
2018
Università Cattolica del Sacro Cuore
2018
John Wiley & Sons (United States)
2018
We report results from a phase II study assessing the efficacy of WEE1 inhibitor adavosertib with cisplatin in metastatic triple-negative breast cancer (mTNBC).Patients mTNBC treated 0-1 prior lines chemotherapy received 75 mg/m2 i.v. followed 21 days later by plus 200 mg oral twice daily for five doses every days. The had 90% power to detect difference between null (20%) and alternative (40%) objective response rates (ORR) one-sided type I error 0.1: an ORR >30% was predefined as making...
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy, recently recognized as provisional entity by the World Health Organization. Although increasing data have been published on this in recent years, great number of patients and health professionals remain unaware diagnosis.We herein report case 56-year-old female with Li-FRAUMENI syndrome who presented late right-sided recurrent breast swelling after prophylactic adenomastectomy implant reconstruction....
Introduction: The International System for Reporting Serous Fluid Cytopathology (ISRSFC) has recently been announced. Pericardial effusion (PE) is a clinical manifestation of large variety both neoplastic and non-neoplastic conditions. Herein, we have applied the ISRSFC on reporting PE cytopathology report our experience in academic institution. Method Materials: After Institutional Research Board approval, electronic pathology database institution was queried PEs collected from January 2014...
This single-arm phase II study investigated the efficacy and safety of cabozantinib combined with nivolumab in metastatic triple-negative breast cancer (mTNBC). The primary endpoint was objective response rate (ORR) by RECIST 1.1. Biopsies at baseline after cycle 1 were analyzed for tumor-infiltrating lymphocytes (TILs), PD-L1, whole-exome transcriptome sequencing. Only 1/18 patients achieved a partial (ORR 6%), trial stopped early. Toxicity led to dose reduction 50% patients. One patient...
Abstract NeuVax is a vaccine comprised of the HER2-derived MHC class I peptide E75 (nelipepimut-S, NPS) combined with GM-CSF. We completed randomized trial preoperative vaccination versus GM-CSF alone in patients ductal carcinoma situ (DCIS). The primary objective was to evaluate for NPS-specific cytotoxic T lymphocyte (CTL) responses. Patients human leukocyte antigen (HLA)-A2-positive DCIS were enrolled and 2:1 received two inoculations prior surgery. number CTL measured pre-vaccination, at...
Abstract Emerging data suggests that HER2 intratumoral heterogeneity (ITH) is associated with therapy resistance, highlighting the need for new strategies to assess ITH. A promising approach leveraging multiplexed tissue analysis techniques such as cyclic immunofluorescence (CyCIF), which enable visualization and quantification of 10–60 antigens at single-cell resolution from individual sections. In this study, we qualified a breast cancer-specific antibody panel, including HER2, ER, PR,...
The impact of rapid on-site evaluation (ROSE) on thyroid aspirates has been a matter extensive debate. In the current study, authors reviewed all fine-needle aspiration biopsies (FNABs) performed in their service recent years to evaluate ROSE final adequacy and diagnostic rates.All ultrasound-guided FNABs between July 2015 2017 were included retrospectively. was by experienced cytopathologists, with production Romanowsky-stained slides for immediate evaluation. When not performed, total 3...
Abstract Background: TOPACIO was a phase I/II study evaluating the PARP inhibitor (PARPi) niraparib in combination with anti-PD-1 antibody pembrolizumab patients locally advanced or metastatic triple-negative breast cancer (TNBC, n=55), irrespective of BRCA status. In efficacy-evaluable population (n=47) objective response rate (ORR) 21% and disease control (DCR) 49%. Although activity greater BRCA-MUT (7/15, ORR=47% 12/15, DCR=80%), durable clinical benefit seen BRCA-WT tumors (3/27,...
T cells are sparse in hormone receptor-positive (HR+) breast cancer, potentially due to limited antigen presentation, but the mechanisms remain unclear. This study aimed elucidate how estrogen receptor (ER) signaling (ERS) modulates immune pathways and tumor microenvironment using bulk single-cell RNA sequencing (scRNA-seq) data spatial analysis via multiplexed cyclic immunofluorescence (CyCIF). Analysis of HR+/HER2- patients from TCGA METABRIC datasets identified co-expressed gene modules...
Recently, the longitudinal location of a nodule within thyroid lobe was found to be associated with distinct risks malignancy, isthmic and upper lobar lesions presenting highest risk. In large cohort presented in current study, authors input additional data into examining association between localization nodules their risk statistically significantly higher cancer compared those localized lateral lobes. The findings should bring even more attention this portion gland, particular followed closely.
Background Rapid on‐site evaluation is a great tool for optimizing the adequacy and quality of cytologic samples. The objective current study was to analyze low‐cost telecytopathology method remote assessment thyroid fine‐needle aspiration biopsies (FNABs), with comparison primarily rendered diagnosis final conventional analysis. Methods Material collected from FNABs immediately smeared onto glass slides stained Diff‐Quik. A microscope attached smart device operated by either medical student...
<b><i>Introduction:</i></b> Pulmonary adenocarcinoma is a major cause of mortality worldwide. The majority patients present with advanced stage disease, and minimally invasive procedures are desirable for diagnosis treatment plans. Herein, we report our experience percutaneous/transthoracic needle aspiration (TT-NA) in the cytologic pulmonary adenocarcinoma. <b><i>Material Methods:</i></b> After institutional review board approval,...
Abstract Introduction The Bethesda System recommends repeat fine needle aspiration (rFNA) as a management option for nodules classified under the non‐diagnostic (ND) and atypia of undetermined significance (AUS/FLUS) categories. We evaluated impact an rFNA in diagnostic resolution role early (≤3 months) vs delayed (more than 3 initially diagnosed ND AUS/FLUS. Methods retrospectively collected all thyroid FNA performed 4‐year period with aspiration. For cases signed out or AUS/FLUS, was...
Extracerebral toxoplasmosis, with pulmonary involvement and shock, is a rare form of toxoplasmosis in patients advanced AIDS. It can mimic pneumocystosis, histoplasmosis, disseminated tuberculosis, should be considered the differential diagnosis causes respiratory failure fulminant disease this group individuals, especially areas where Toxoplasma gondii infection highly prevalent those without proper use antimicrobial prophylaxis. We report case 46-year-old male patient who presented to...
A definitive diagnosis of malignancy may not be possible in pleural effusions. We report our experience with the suspicious for (SFM) effusion.A search effusions diagnosed as SFM (2008-2018) was performed. Patient records and pathology reports were reviewed. Specimens subdivided into groups depending on volume (<75, 75-400, >400 mL). Diagnoses malignant effusion (MPE) served controls.We identified 90 patients, a mean age 60.6 years. included involvement by carcinoma/adenocarcinoma 64.4%,...
The Roux-en-Y gastric bypass is one of the most common procedures currently performed for surgical treatment patients with severe obesity. Gastric cancer after bariatric surgery not common, them arising in excluded stomach. mixed adenoneuroendocrine carcinomas are a rare type stomach malignancy, composed both adenocarcinoma and neuroendocrine tumor-cell components, latter comprising at least 30% whole neoplasm. In this article, we report unique case carcinoma (tubular poorly cohesive)...