A5060723951- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Cancer and Skin Lesions
- Immunotherapy and Immune Responses
- Breast Implant and Reconstruction
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- Women's cancer prevention and management
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Cancer Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Medical Imaging Techniques and Applications
- Genetic factors in colorectal cancer
- Molecular Biology Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Metastasis and carcinoma case studies
- Estrogen and related hormone effects
AC Camargo Hospital
2016-2025
Universidade Federal de Goiás
2023
Hospital São Paulo
2011-2022
Instituto Brasileiro de Controle do Câncer
1999-2001
Universidad de Granada
1982
Abstract Introduction Ductal carcinoma in situ (DCIS) of the breast includes a heterogeneous group preinvasive tumors with uncertain evolution. Definition molecular factors necessary for progression to invasive disease is crucial determining which lesions are likely become invasive. To obtain insight into basis DCIS, we compared gene expression pattern cells from following samples: non-neoplastic, pure component co-existing ductal carcinoma, and carcinoma. Methods Forty-one samples were...
Germline TP53 mutations predispose individuals to multiple cancers and are associated with Li-Fraumeni/Li-Fraumeni-Like Syndromes (LFS/LFL). The founder mutation p.R337H is detected in 0.3% of the general population southern Brazil. This an increased risk childhood adrenal cortical carcinoma (ACC) but also common Brazilian LFS/LFL families. Breast Cancer (BC) one most diagnosed carriers. We have assessed prevalence two groups: (1) 59 BC affected women a familial history (FH) suggestive...
The purpose of this study was to evaluate the capacity diffusion-weighted magnetic resonance imaging (DW-MRI) for early prediction pathological response in breast cancer patients undergoing neoadjuvant chemotherapy (NCT). This prospective unicentric evaluated 62 who underwent NCT. MRI performed prior start treatment (MR1), after first NCT cycle (MR2), and upon completion (MR3). Pathological used as gold-standard. Patients' median age 45.5 years tumor size 40 mm. Twenty-four (38.7%) tumors...
DNA repair deficiency (DRD) is an important driver of carcinogenesis and efficient target for anti-tumor therapies to improve patient survival. Thus, detection DRD in tumors paramount. Currently, determination dependent on wet-lab assays. Here we describe machine learning algorithm which can predict from histopathological images. The utility this demonstrated with data obtained 1445 cancer patients. Our method performs rather well when trained breast specimens homologous recombination (HRD),...
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy, recently recognized as provisional entity by the World Health Organization. Although increasing data have been published on this in recent years, great number of patients and health professionals remain unaware diagnosis.We herein report case 56-year-old female with Li-FRAUMENI syndrome who presented late right-sided recurrent breast swelling after prophylactic adenomastectomy implant reconstruction....
To correlate the results of (18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) performed with a specific protocol for assessment breasts histological/immunohistochemical findings in breast carcinoma patients.Cross-sectional study prospective data collection, where patients biopsy-confirmed carcinomas were studied. The underwent PET/CT examination prone position, breasts. compared histological and immunohistochemical data.The authors...
<b><i>Background:</i></b> ADAMTS are metalloproteases with disintegrin and thrombospondin motifs. They secreted proteases playing a role in biological processes such as inflammation, angiogenesis, urogenital development. have specific substrates, the proteoglycans (PG) versican, aggrecan, brevican. Despite data indicating of tumor invasion metastases, effects played by these molecules cancer progression still controversial. In ovarian cancer, importance gene mutations...
Aims GATA 3 has been reported as a specific urothelial marker among organs in the pelvic region, and classified highly sensitive for breast carcinomas. Our aim was to verify expression extramammary Paget disease, determine whether it can be use differentiate primary vulvar disease from pagetoid intraepithelial neoplasia ( PUIN ). We also analysed HER 2 protein gene amplification their roles prognostic factors disease. Methods results 11 cases two cases. All showed nuclear of 3. Of 13 cases,...
Background: DNAJC12 (DnaJ heat shock protein family (Hsp40) member C12) encodes a of the molecular chaperone Hsp40/DnaJ family, which are important folding and proteostasis regulators. Its role as biomarker has been studied for limited number cancer types. Objectives: Here, we sought to investigate potential mRNA expression prognostic predictive breast (BC). Methods: Using in silico analysis data from immunohistochemistry (IHC) 292 samples patients with primary BC, determined pattern value...
// Otto L.D. Cerqueira 1 , Peter Truesdell 2 Tomas Baldassarre Santiago A. Vilella-Arias Kathleen Watt Jalna Meens Harish Chander Cynthia A.B. Osório 3 Fernando Soares 3, 4 Eduardo M. Reis 1, Andrew W.B. Craig Departamento de Bioquímica, Instituto Química, Universidade São Paulo, SP, Brazil Department of Biomedical and Molecular Sciences, Queen's University, Division Cancer Biology & Genetics, Research Institute, Kingston, ON, Canada Anatomic Pathology, A.C. Camargo Hospital, Nacional...
Abstract Objective: To assess the role of diffusion-weighted imaging (DWI) in evaluation breast lesions classified as suspicious on magnetic resonance (MRI), correlating findings with results histological analysis. Materials and Methods: This was a retrospective, descriptive study based review medical records 215 patients who were submitted to MRI DWI before undergoing biopsy at cancer center. Apparent diffusion coefficient (ADC) values calculated for each lesion, result analysis considered...
Inflammatory breast cancer (IBC) is a rare and aggressive type of whose molecular basis poorly understood. We performed comprehensive analysis 24 IBC biopsies naïve treatment, using high-resolution microarray platform targeted next-generation sequencing (105 cancer-related genes). The genes more frequently affected by gains were MYC (75%) MDM4 (71%), while frequent losses encompassed TP53 (71%) RB1 (58%). Increased protein expression levels detected in 18 cases. These have been related to...
Breast cancer is the most prevalent among women, with basal-like triple negative (TNBC) being agressive one, displaying poorest prognosis within ductal carcinoma subtype. Due to lack of adequate molecular targets, diagnosis and treatment patients TNBC phenotype has been a great challenge. In previous work, we identified CD90/Thy-1 as highly expressed in aggressive high malignancy grade Hs578T breast tumor cell line, pointing this molecule promising marker, which should be further...
Logullo A F, Stiepcich M Á, de Toledo Osório C B, Nonogaki S, Pasini F Rocha R M, Soares & Brentani (2011) Histopathology 58 , 617–625 Role of Fos‐related antigen 1 in the progression and prognosis ductal breast carcinoma Aims: (Fra‐1) is a member activator protein (AP‐1) transcription factor family. Our objective was to evaluate role Fra‐1 expression prognosis. Methods results: investigated by immunohistochemistry two tissue microarrays containing, respectively, 85 situ (DCIS) 771...
Human epidermal growth factor receptor 2 (HER2)-low breast cancer has emerged as a new subtype of tumor, for which novel antibody-drug conjugates have shown beneficial effects. Assessment HER2 requires several immunohistochemistry tests with an additional in situ hybridization test if case is classified 2+. Therefore, cost-effective methods to speed up the assessment are highly desirable.
Alterations in the gene expression profile epithelial cells during breast ductal carcinoma (DC) progression have been shown to occur mainly between pure situ (DCIS) component of a lesion with coexisting invasive (DCIS-IDC) implying that molecular program for invasion is already established preinvasive lesion. For assessing early alterations trigger tumorigenesis and testing them as prognostic markers progression, we analyzed, by reverse transcription-quantitative polymerase chain reaction,...
Epithelial intercellular cohesion, mainly mediated by E-cadherin (CDH1) expression and function, may be deregulated during cancer cell invasion of adjacent tissues lymphatic vascular channels. CDH1 is down-modulated in invasive lobular breast carcinomas but its regulation ductal (IDC) less clear. repressed transcription factors such as Snail (SNAI1) product degraded after Hakai ubiquitination. We compared CDH1, SNAI1 HAKAI mRNA IDC paired normal tissue evaluated relation with node metastasis...