A5040829611- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Head and Neck Surgical Oncology
- Parkinson's Disease Mechanisms and Treatments
- Cancer Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Lung Cancer Treatments and Mutations
- Neurological disorders and treatments
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ovarian cancer diagnosis and treatment
- Colorectal and Anal Carcinomas
- Cervical Cancer and HPV Research
- Photoacoustic and Ultrasonic Imaging
- Oral Health Pathology and Treatment
- Cancer Cells and Metastasis
- Vitamin D Research Studies
- Nanoparticle-Based Drug Delivery
Chang Gung Memorial Hospital
2016-2025
Chang Gung University
2016-2025
Kaohsiung Chang Gung Memorial Hospital
2017-2024
Linkou Chang Gung Memorial Hospital
2013-2023
Xiamen Chang Gung Hospital
2018-2020
Imaging Center
2008-2019
Taoyuan Chang Gung Memorial Hospital
2005-2018
Bridge University
1996-2016
Restaurant Opportunities Centers United
2016
Memorial Hospital of South Bend
2003-2015
Purpose To demonstrate the feasibility of using focused ultrasound to enhance delivery 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) glioblastomas in rats with induced tumors and determine if such an approach increases treatment efficacy. Materials Methods All animal experiments were approved by committee adhered experimental care guidelines. A 400-kHz generator was used transcranially disrupt blood-brain barrier (BBB) rat brains delivering burst-tone energy presence microbubbles. The process...
The current American Joint Committee on Cancer (AJCC) staging system for oral cancer demonstrates wide prognostic variability within each primary tumor stage and provides suboptimal information some patients.To determine if a modified that integrates depth of invasion (DOI) into the T categories improves performance compared with AJCC staging.Retrospective analysis 3149 patients squamous cell carcinoma treated curative intent at 11 comprehensive centers worldwide between 1990 2011 surgery ±...
The aim of this case series is to illustrate the 18F-FDG PET/CT findings patients with acute respiratory disease caused by COVID-19 in Wuhan, Hubei province China.We describe results from four who were admitted hospital symptoms and fever between January 13 20, 2020, when outbreak was still unrecognized virus infectivity unknown. A retrospective review patients' medical history, clinical laboratory data, as well imaging strongly suggested a diagnosis COVID-19.All had peripheral ground-glass...
This study investigates the effects of chitosan (CS) on opening epithelial tight junctions (TJs) and paracellular transport at microscopic, ultrastructural, computed-tomographic levels in Caco-2 cell monolayers animal models. Using immunofluorescence staining, CS treatment was observed to be associated with translocation JAM-1 (a trans-membrane TJ protein), resulting disruption TJs; removal accompanied by recovery JAM-1. Ultrastructural observations TEM reveal that slightly opened apical...
The purpose of this study is to assess the preclinical therapeutic efficacy magnetic resonance imaging (MRI)-monitored focused ultrasound (FUS)-induced blood-brain barrier (BBB) disruption enhance Temozolomide (TMZ) delivery for improving Glioblastoma Multiforme (GBM) treatment. MRI-monitored FUS with microbubbles was used transcranially disrupt BBB in brains Fisher rats implanted 9L glioma cells. FUS-BBB opening spectrophotometrically determined by leakage dyes into brain, and TMZ...
Abstract Background Plasma glial fibrillary acidic protein (GFAP) has emerged as a promising biomarker in neurological disorders, but further evidence is required relation to its usefulness for diagnosis and prediction of Alzheimer disease (AD). Methods GFAP was measured participants with AD, non-AD neurodegenerative controls. Its diagnostic predictive value were analyzed alone or combined other indicators. Results A total 818 recruited (210 followed). significantly higher AD than dementia...
Purpose To assess the clinical usefulness of [ 18 F]fluorodeoxyglucose positron emission tomography ([ F]FDG PET) as well computed (CT) or magnetic resonance imaging (MRI) in oral squamous cell carcinoma (SCC) patients with palpably negative neck. Patients and Methods In total, 134 SCC neck were prospectively evaluated PET, CT/MRI, their visual correlation. Histopathologic analysis was used gold standard for assessment these techniques. Results Thirty-five (26.1%) our found to have...
Abstract Purpose To evaluate diffusion‐weighted imaging (DWI) for detection of pelvic lymph node metastasis in patients with cervical and uterine cancers. Materials Methods Fifty scheduled dissection were enrolled 3T magnetic resonance (MRI) using a single‐shot echo‐planar DWI technique, body‐phased array coil, b = 0, 1000 s/mm 2 . We measured short/long‐axis diameters, mean apparent diffusion coefficient (ADC) values all identifiable nodes, relative ADC between tumors utilized their cutoff...
Lymph node density (LND) has previously been reported to reliably predict recurrence risk and survival in oral cavity squamous cell carcinoma (OSCC). This multicenter international study was designed validate the concept of LND OSCC. The included 4254 patients diagnosed as having median follow-up 41 months. Five-year overall (OS), disease-specific (DSS), disease-free (DFS), locoregional control distant metastasis rates were calculated using Kaplan–Meier method. (number positive lymph...
To assess the diagnostic accuracy of fused T2-weighted and high-b-value diffusion-weighted (DW) magnetic resonance (MR) images at 3 T for evaluation myometrial invasion in patients with endometrial cancer.Institutional review board approval informed consent were obtained. From May 2006 to October 2007, 48 consecutive aged 25-80 years (mean age, 57 years) who had cancer prospectively enrolled preoperative by using a 3-T MR unit. Two radiologists interpreted depth on images, dynamic contrast...
Abstract MicroRNAs offer tools to identify and treat invasive cancers. Using highly isogenic oral squamous cell carcinoma (OSCC) cells, established using in vitro vivo selection protocols from poorly parental populations, we used microarray expression analysis a relative specific decrease miR-491-5p cells. Lower of correlated with poor overall survival patients OSCCs. overexpression OSCC cells suppressed their migratory behavior lung metastatic vivo. We defined the G-protein—coupled receptor...
An association between the survival of patients with oral cavity squamous cell carcinoma (OCSCC) and advancements in diagnosis therapy has not been established.This was a retrospective, longitudinal, international, population-based study 2738 who underwent resection OCSCC during 2 different decades. Characteristics from 7 international cancer centers received treatment 1990 2000 (group A; n = 735) were compared 2001 2011 B; 2003).Patients group B had more advanced tumors tended to develop...
Molecular methods for predicting prognosis in patients with oral cavity squamous cell carcinoma (OSCC) are urgently needed, considering its high recurrence rate and tendency metastasis. The present study investigated the genetic basis of variations gene expression associated poor OSCC using Affymetrix SNP 6.0 GeneChip Human Gene 1.0 ST arrays. We identified recurrent DNA amplifications scattered from 8q22.2 to 8q24.3 112 specimens. These amplicons demonstrated significant associations...
// Miao-Fen Chen 1,2 , Feng-Che Kuan 2,3 Tzu-Chen Yen 4,5 Ming-Shian Lu 6 Paul-Yang Lin 7 Yi-Hsiu Chung 5 Wen-Cheng and Kuan-Der Lee 1 Department of Radiation Oncology, Chang Gung Memorial Hospital at Chiayi, Taiwan 2 University, College Medicine, 3 Hematology 4 Nuclear Medicine Department, Linko, Center for Advanced Molecular Imaging Translation, Hospital, Thoracic & Cardiovascular Surgery, Pathology, Correspondence: email: Keywords : IL-6; esophageal SCC; MDSC Received July 07, 2014...
Previous studies have shown that total lesion glycolysis (TLG) may serve as a prognostic indicator in oropharyngeal squamous cell carcinoma (OPSCC). We sought to investigate whether the textural features of pretreatment (18)F-FDG PET/CT images can provide any additional information over TLG and clinical staging patients with advanced T-stage OPSCC.We retrospectively analyzed 70 OPSCC who had completed concurrent chemoradiotherapy, bioradiotherapy, or radiotherapy curative intent. All data on...