A5101497690- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Immunotherapy and Immune Responses
- interferon and immune responses
- Cancer Cells and Metastasis
- Liver physiology and pathology
- CAR-T cell therapy research
- DNA Repair Mechanisms
- Chemical Reactions and Isotopes
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Cancer therapeutics and mechanisms
- Intensive Care Unit Cognitive Disorders
- S100 Proteins and Annexins
- Cancer-related gene regulation
- COVID-19 Clinical Research Studies
- HER2/EGFR in Cancer Research
- Long-Term Effects of COVID-19
Guangdong Provincial People's Hospital
2015-2024
Guangdong Academy of Medical Sciences
2014-2022
Guangdong General Hospital
2011-2021
Cancer Institute (WIA)
2017-2021
Southern Medical University
2012-2020
Nanfang Hospital
2012
Purpose: Although clinical studies have shown promise for targeting programmed cell death protein-1 (PD-1) and ligand (PD-L1) signaling in non-small lung cancer (NSCLC), the factors that predict which subtype patients will be responsive to checkpoint blockade are not fully understood.Experimental Design: We performed an integrated analysis on multiple-dimensional data types including genomic, transcriptomic, proteomic, from cohorts of adenocarcinoma public (discovery set) internal...
Corona virus disease 2019 (COVID-19) patients with severe immune abnormalities are at risk of cytokine release syndrome (CRS). The definition, prevention, and treatment symptoms CRS in critically ill COVID-19 important problems. We report a single-center case series 11 acute respiratory distress from First Affiliated Hospital Guangzhou Medical University China 26 January 2020 to 18 February 2020. termination date follow-up was 19 Eight were determined have characteristics CRS, including...
Radiotherapy is the most successful nonsurgical treatment for nasopharyngeal carcinoma (NPC). Despite this, prognosis remains poor. Although NPCs initially respond well to a full course of radiation, recurrence frequent. The cancer stem cell (CSC) hypothesis provides framework explaining discrepancy between response NPC therapy and poor survival rate. In this study, cell-like subpopulation (PKH26+) was identified in lines using label-retention technique. PKH26+ cells were enriched...
IMPORTANCE COVID-19-infected pneumonia patients with severe immune abnormalities and risk of cytokine release syndrome. The definition, prevention, treatment in critically ill syndrome symptoms is an important problem. OBJECTIVE To define the syndrome-like (CRSL) study factors therapeutic strategies. DESIGN, SETTING, AND PARTICIPANTS This a retrospective, single center case 11 acute respiratory distress (ARDS) from First Affiliated Hospital Guangzhou Medical University China January 26, 2020...
Purpose:MET amplification, responsible for 20% of acquired resistance to EGFR tyrosine kinase inhibitor (TKI) in patients with advanced non-small cell lung cancer (NSCLC), presents an attractive target. Numerous studies have conferred susceptibility MET mutations and focal amplification targeted MET-TKIs. However, the mechanism underlying MET-TKIs-induced remains elusive.Experimental Design: We conducted a cohort 12 NSCLC who developed combinatorial therapy consisting gefitinib type I...
Abstract Background Although the prognostic roles of β-catenin expression in non-small cell lung cancer (NSCLC) have been reported several immunohistochemical (IHC) studies, results were not consistent because some studies lack sufficient number positive cases or did evaluate subcellular localization features protein. Method In this study, we evaluated levels and Nanog proteins IHC staining tissue specimens from 309 patients with NSCLC, explored their association clinicopathological patient...
Radiotherapy is a major treatment regime for nasopharyngeal carcinoma (NPC), and although initial responses to complete course of radiation are good, recurrence metastasis frequent events. A number previous studies have observed that ionizing (IR) may enhance the migratory invasive properties cancer cells through epithelial‑mesenchymal transition (EMT). In present study, tumor cohort 22 NPC 7 normal cases (chronic inflammation only) were investigated expression AKT was demonstrated...
Radiotherapy is the most successful nonsurgical treatment for nasopharyngeal carcinoma (NCP). Although NPCs initially respond well to a full course of radiation, recurrence and metastasis are frequent. In this study, we found that down‐regulated c‐MYB expression was associated with increased radiation resistance DNA damage repair ability. Interestingly, over‐expressed in cancer tissues but not adjacent tissues. Down‐regulation inhibited cell proliferation, led cycle arrest at M phase NPC...
Background: The aims of this study were to analyze the association LMO4 with non-small-cell lung cancer (NSCLC) survival rate, and determine its functional role signaling pathway in cancer. Methods: Immunohistochemistry (IHC) was used detect expression NSCLC cell lines tumor tissues. Migration invasion ability detected respectively by wound healing test transwell test. Immunofluorescence western blot AKT/PI3K related genes MAPK, PI3K, AKT. Results: has high level tissues, correlated a lower...
X-ray radiation resistance associated 1 (XRRA1) has been found to regulate the response of human tumor and normal cells X-radiation (XR). Although XRRA1 overexpression is known be involved in cancer cell XR, there are no reports about whether expression tumors can adjust radioresistance. It widely that cycle arrest could cause We blocked lead G2/M by regulation cyclin A, E, p21 proteins colorectal (CRC) reduced increased proliferation CRC. However, influence radioresistance poorly...
Bone metastasis and skeletal related events (SREs) are common in non-small cell lung cancer (NSCLC). Patients with mutant epidermal growth factor receptor (EGFR) could benefit from tyrosine kinase inhibitors (TKIs). However, it is unclear whether SRE influenced by EGFR status. We aimed to evaluate the correlation of status TKIs incidence SREs.We conducted a retrospective study stage IV NSCLC patients bone metastasis. Incidence rate SREs was collected compared using chi-square test....
Abstract Objective NF1 is a tumor suppressor gene that encodes the neurofibromin protein and negatively regulates Ras signaling. This study was aimed to investigate molecular, clinical characteristics, prognostic features of in EGFR mutant lung cancer patients. Method The next‐generation sequencing (NGS) used analyze data from patients Guangdong Lung Cancer Institute (GLCI) June 2016 December 2020. Results Somatic mutations were present 4.2% (135/3220) Chinese where clearly enriched older (...
The proto-oncogene c-MET (mesenchymal-epithelial transition factor gene) plays a critical role in cellular proliferation, survival, migration, and invasion cancers. aim of this study is to explore the relationship between expression clinicopathological characteristics colorectal cancer (CRC) patients.A total 337 enrolled patients were collected present study. Here, EGFR detected by immunohistochemistry (IHC). mutational statuses KRAS exons 2, 3, 4, NRAS BRAF exon 15 from formalin-fixed...
Background Fever is a common biological phenomenon during the occurrence of infections and tumors in body. However, it unclear whether increase body temperature tumor patients has an impact on immune cells patient prognosis, as well underlying molecular regulatory mechanisms. Its effects patient's disease outcome immunotherapy efficacy are also uncertain. Clarifying mechanism fever will provide new ideas for predicting prognosis formulating strategies. Methods T were cultured at 37.0°C...
Achieving long-term allograft survival or tolerance without continuously global immunosuppression is a highly desirable goal in transplantation. The objective of this study to induce conventional via short-term treatments with novel protein ESAT-6, which originally identified as T cell Ag the culture filtrate M. tuberculosis. Previous studies have shown that ESAT-6 virulence factor promotes growth and pathogenesis tuberculosis while briefly weakening an individual's immunity. In study,...
<h3>Background</h3> Recent findings suggest a link between inflammatory processes and the development of atrial fibrillation (AF). Many studies have investigated role C-reactive protein (CRP) in AF, but few concentrated on tumour necrosis factor-α (TNFα) its pathogenesis. <h3>Aims</h3> The aim was to study possible associations SNPs TNFα gene promoter serum with AF Chinese Han population, thus help establish relationship inflammation AF. <h3>Methods</h3> A pairwise case control 301...