A5103112041- Immune Cell Function and Interaction
- Influenza Virus Research Studies
- interferon and immune responses
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Iron-based superconductors research
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Inflammasome and immune disorders
- vaccines and immunoinformatics approaches
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Renal Diseases and Glomerulopathies
- Ion Channels and Receptors
- Physics of Superconductivity and Magnetism
- Reading and Literacy Development
- Phosphorus and nutrient management
- 2D Materials and Applications
- Educational and Psychological Assessments
- Complement system in diseases
- COVID-19 and healthcare impacts
- Antimicrobial Peptides and Activities
- Topological Materials and Phenomena
- Random lasers and scattering media
- Sphingolipid Metabolism and Signaling
The First Affiliated Hospital, Sun Yat-sen University
2020-2024
Sun Yat-sen University
2020-2024
Fujian Normal University
2023
Fuzhou University
2023
Hangzhou Normal University
2014-2023
University of Shanghai for Science and Technology
2014-2022
Sensors (United States)
2021
Shenyang Pharmaceutical University
2018-2020
Early identification of patients with novel coronavirus disease 2019 (COVID-19) who may develop critical illness is great importance and aid in delivering proper treatment optimizing use resources.To validate a clinical score at hospital admission for predicting which COVID-19 will based on nationwide cohort China.Collaborating the National Health Commission China, we established retrospective from 575 hospitals 31 provincial administrative regions as January 31, 2020. Epidemiological,...
Tissue-resident memory T cells (TRM cells) have been shown to play an instrumental role in providing local immune responses for pathogen clearance barrier tissues. However, their contribution inflammatory bowel diseases (IBDs) and the underlying regulation are less clear. Here, we identified a critical of T-cell immunoreceptor with immunoglobulin ITIM (TIGIT) regulating CD4+ TRM experimental model intestinal inflammation. We found that were increased correlated disease activities mice...
Vaccination is important in influenza prevention but the immune response wanes with age. The circadian nature of system suggests that adjusting time vaccination may provide an opportunity to improve immunogenicity. Our previous cluster trial Birmingham suggested differences between morning and afternoon for some strains vaccine older adults. Whether this effect also seen a younger age group less likelihood compromised immunity unknown. We therefore conducted individual-based randomized...
We report details of single-crystal growth stoichiometric bismuthide ${\mathrm{PtBi}}_{2}$ whose structure consists alternate stacking a Pt layer and Bi bilayer along the $c$ axis. The compound crystallizes in space group $P3$ with hexagonal unit cell $a=b=6.553\phantom{\rule{0.16em}{0ex}}\text{\AA{}},c=6.165\phantom{\rule{0.16em}{0ex}}\text{\AA{}}$. Its $T$-dependent resistivity is typical metal whereas large anisotropy was observed for in-plane interplane electrical transport....
Electronic nematics, an electron orientational order which breaks the underlying rotational symmetry, were observed in iron pnictide superconductors several years after their discovery. However, universality of doping dependence this phase and its relation to other symmetry-breaking orders (such as superconductivity) distinct families pnictides remain outstanding questions. Here we use torque magnetometry a probe study symmetry breaking...
Upon activation, naive B cells exit their quiescent state and enter germinal center (GC) responses, a transition accompanied by increased protein synthesis. How translation efficiency is adequately adjusted to meet the demand requires further investigation. Here, we identify methyltransferase METTL1 as translational checkpoint during GC responses. Conditional knockout of Mettl1 in mouse blocks entry impairs formation, whereas conditional knock-in promotes Mechanistically, catalyzes m7G...
Renal CD8+ tissue-resident memory T (TRM) cells display prolonged survival and activity in lupus nephritis (LN), exacerbating renal pathology. NLRP3 regulates the cell response. This study explored impact of inflammasome on regulatory functions TRM LN. from lupus-prone MRL/lpr mice vitro induced human CD8+CD103+ was assessed by quantifying NLRP3, caspase-1, gasdermin D (GSDMD), IL-1β levels using flow cytometry, ELISA, western blotting analysis. The specific inhibitor MCC950, caspase-1...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes disease 2019 (COVID-19), which is still devastating economies and communities globally. The increasing infections of variants concern (VOCs) in vaccinated population have raised concerns about the effectiveness current vaccines. Patients with autoimmune diseases (PAD) under immunosuppressant treatments are facing higher risk potentially lower immune responses to SARS-CoV-2 vaccination.Blood samples were collected...
A series of NH2-sulfonyl oseltamivir analogues were designed, synthesized, and their inhibitory activities against neuraminidase from H5N1 subtype evaluated. The results indicated that the IC50 value compound 4a, an analogue via methyl sulfonylation C5-NH2, was 3.50 μM. Molecular docking simulations suggested 4a retained most interactions formed by carboxylate moieties additional hydrogen bond with methylsulfonyl group. Meanwhile, showed high stability towards human liver microsomes. More...
Store-operated Ca 2+ release-activated (CRAC) channel is the main influx pathway in lymphocytes and essential for immune response. Lupus nephritis (LN) an autoimmune disease characterized by production of autoantibodies due to widespread loss tolerance. In this study, RNA-seq analysis revealed that calcium transmembrane transport activity were enhanced naive B cells from patients with LN. The increased expression ORAI1, ORAI2, STIM2 LN was confirmed flow cytometry Western blot, implying a...
Current studies of chromium adsorption kinetics at the solid–liquid interface often neglect influence coexisting ions in complex wastewaters. Thus, it is critical to explore hexavalent Cr(VI) solid-phase brucite (Mg(OH)2) liquid-phase wastewater containing aluminum (Al(III)). This paper reveals that presence Al(III) significantly enhanced efficiency onto Mg(OH)2, with a peak up 91% compared 5% for absence Al(III). The main reason this enhancement was initial surface ternary complexation...
OPINION article Front. Psychol., 17 February 2023Sec. Educational Psychology Volume 14 - 2023 | https://doi.org/10.3389/fpsyg.2023.1128089