A5100391553- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- Data Management and Algorithms
- AI in cancer detection
- PI3K/AKT/mTOR signaling in cancer
- Carbohydrate Chemistry and Synthesis
- Graph Theory and Algorithms
- Microtubule and mitosis dynamics
- COVID-19 diagnosis using AI
- Radiomics and Machine Learning in Medical Imaging
- Semantic Web and Ontologies
- Antenna Design and Analysis
- Cancer-related Molecular Pathways
- Energy Harvesting in Wireless Networks
- Histone Deacetylase Inhibitors Research
- Neuroscience and Neuropharmacology Research
- Glycosylation and Glycoproteins Research
- Glioma Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Advanced Graph Neural Networks
- CRISPR and Genetic Engineering
- Laser-Ablation Synthesis of Nanoparticles
- Peacebuilding and International Security
- Cholinesterase and Neurodegenerative Diseases
Morgan Adams Foundation
2020-2025
State Key Laboratory of Estuarine and Coastal Research
2022-2025
East China Normal University
2007-2025
Peking University
2010-2024
University of Colorado Denver
2020-2024
Gansu Agricultural University
2024
University of Colorado Anschutz Medical Campus
2024
Children's Hospital Colorado
2024
State Key Laboratory of Membrane Biology
2023
Shandong University
2023
Abstract Commercial sunscreens usually rely on multiple component formulas against solar irradiation, including UV filters, antioxidants, and nanomaterial matrices. While many efforts are devoted, concern has arisen that the effectiveness safety issues of most largely limited by their complex formulations, photostability, toxicity. Inspired skin pigmentation as primary photoprotective mechanism in human body, novel sunscreen products based polydopamine (PDA) gels, with a bioinspired...
Accumulating evidence suggested that an orphan G protein-coupled receptor (GPR)30, mediates nongenomic responses to estrogen. The present study was performed investigate the molecular mechanisms underlying GPR30 function. We found knockdown of expression in breast cancer SK-BR-3 cells down-regulated levels estrogen (ER)-α36, a variant ER-α. Introduction vector into nonexpressing induced endogenous ER-α36 expression, and cotransfection assay demonstrated activated promoter activity via...
Since many graph data are often noisy and incomplete in real applications, it has become increasingly important to retrieve graphs g the database D that approximately match query q, rather than exact matching. In this paper, we study problem of similarity search, which retrieves similar a given under constraint edit distance. We propose systematic method for edit-distance based search problem. Specifically, derive two lower bounds, i.e., partition-based branch-based from different...
As important as memory is to our daily functions, the ability extract fundamental features and commonalities from various episodic experiences then generalize them into abstract concepts even more crucial for both humans animals adapt novel complex situations. Here, we report neural correlates of concept nests or beds in mice. Specifically, find hippocampal neurons that selectively fire cease when mouse perceives beds, regardless their locations environments. Parametric analyses show...
Due to many real applications of graph databases, it has become increasingly important retrieve graphs g (in database D) that approximately match with query q, rather than exact subgraph matches. In this paper, we study the problem similarity search, which retrieves are similar a given under constraint minimum edit distance. Specifically, derive lower bound, branch-based can greatly reduce search space search. We also propose tree index structure, namely b-tree, facilitate effective pruning...
Abstract Objectives This study aimed to identify novel targets in the carcinogenesis, therapy and prognosis of osteosarcoma from genomic level, together with screening ideal lead compounds potential inhibition regarding MMP-9. Methods Gene expression profiles GSE12865, GSE14359, GSE33382, GSE36001 GSE99671 were obtained respectively GEO database. Differentially expressed genes identified, functional enrichment analysis, such as GO, KEGG, GSEA, PPI performed make a comprehensive understanding...
(AS) is a widely used herb in traditional Chinese medicine, with calycosin as its main isoflavonoid. Our previous study discovered that triggers host defense peptide (HDP) production IPEC-J2 cells. The aim of this to investigate the alleviation effects AS total flavone and on growth performance, intestinal immunity, microflora weaned piglets. Sixty-four piglets were assigned randomly 4 treatment groups, (1) CON: basal diet, (2) P-CON: diet plus antibiotics (1 g/kg), (3) AS-TF: at 60 mg/day...
The overwhelming dispersion of exotic species Spartina alterniflora threatened the structure and function in native coastal ecosystems. Consequently, saltmarshes restoration has emerged as a nature-based solution following removal invasive species. However, given S. alterniflora high carbon sequestration species, it remains uncertain on impacts blue benefits its eradication. Here, this study quantified atmospheric uptake organic storage restored saltmarsh to assess whether...
Background: Medulloblastoma is the most common malignant brain tumor of childhood. The highest-risk tumors are driven by recurrent Myc amplifications (Myc-MB) and experience poorer outcomes despite intensive multimodal therapy. transcription factor defines core regulatory circuitry for these acts to broadly amplify downstream pro-survival transcriptional programs. Therapeutic targeting directly has proven elusive, but inhibiting cofactors may present an indirect means drugging oncogenic...
Introduction: Luscan-Lumish syndrome (LLS) is currently recognized as a rarely-observed condition featured with overgrowth, macrocephaly, obesity, type I Chiari malformation, and linguistic retardation. So far, there have been only few LLS cases registered worldwide, but none of them reported from China. To acquire deeper understanding on the clinical genetic features this disease, Chinese boy caused by heterozygous variant in SETD2 gene was investigated present study. Methods: The patient...
Nine fructose-derived carbohydrates were obtained from the methanol extract rhizome of Alisma orientalis. On basis spectroscopic analysis, their structures determined to be alpha-D-fructofuranose (1), beta-D-fructofuranose (2), ethyl alpha-D-fructofuranoside (3), beta-D-fructofuranoside (4), 5-hydroxymethyl-furaldehyde (5), sucrose (6), raffinose (7), stachyose (8) and verbascose (9), along with two oligosaccharides manninotriose (10) verbascotetraose (11). Compounds 3, 4 7-11 isolated this...
Curcumin, a natural compound extracted from rhizomes of curcuma Curcuma species, has been shown to possess potent anti-inflammatory, anti-tumor and anti-oxidative properties. However, the mechanism action remains poorly understood. In this report, we have analyzed effects curcumin on cell proliferation Burkitt's lymphoma Raji cells. The results demonstrated that could effectively inhibit growth cells in dose- time-dependent manner. Further studies indicated treatment resulted apoptosis...
Computer-aided diagnosis using deep learning algorithms has been initially applied in the field of mammography, but there is no large-scale clinical application.This study proposed to develop and verify an artificial intelligence model based on mammography. Firstly, mammograms retrospectively collected from six centers were randomized a training dataset validation for establishing model. Secondly, was tested by comparing 12 radiologists' performance with without it. Finally, prospectively...