A5100640262- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Immune Cell Function and Interaction
- Microscopic Colitis
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Folate and B Vitamins Research
- Galectins and Cancer Biology
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
- Reproductive System and Pregnancy
- Drug Transport and Resistance Mechanisms
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Monoclonal and Polyclonal Antibodies Research
- Tuberculosis Research and Epidemiology
- Autoimmune and Inflammatory Disorders
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Mycobacterium research and diagnosis
- Gastrointestinal motility and disorders
- Iron Metabolism and Disorders
- NF-κB Signaling Pathways
- Pharmacological Effects of Natural Compounds
Third Affiliated Hospital of Zhengzhou University
2025
Baogang Group (China)
2024
Zhejiang University
2022
Wuhan University
2007-2016
Zhongnan Hospital of Wuhan University
2007-2016
Wuhan Prevention and Treatment Center for Occupational Diseases
2010-2016
Immungenetics (Germany)
2015
Central Hospital of Wuhan
2014
Hubei Provincial Center for Disease Control and Prevention
2010-2013
Chinese University of Hong Kong
2013
<h3>Objective</h3> The rising incidence of inflammatory bowel disease in Asia supports the importance environmental risk factors aetiology. This prospective population-based case-control study Asia-Pacific examined prior to patients developing IBD. <h3>Design</h3> 442 incident cases (186 Crohn9s (CD); 256 UC; 374 Asians) diagnosed between 2011 and 2013 from eight countries Australia 940 controls (frequency-matched by sex, age geographical location; 789 completed an factor questionnaire at...
Background Mouse models have shown that interleukin (IL)6 stimulates survival, proliferation and progression to cancer of intestinal epithelial cells via activation signal transducers activators transcription 3 (STAT3). Objective To investigate the expression IL6/phosphorylated STAT3 (p-STAT3)/suppressor cytokine signalling (SOCS3) in biopsy specimens from patients with ulcerative colitis (UC) UC-related colorectal (CRC) progression. Methods Biopsy inactive UC (n=18), active (n=28),...
Chronic gastritis is one of the most common findings at upper endoscopy in general population, and chronic atrophic epidemiologically associated with occurrence gastric cancer. However, current status diagnosis treatment China unclear. A multi-center national study was performed; all patients who underwent diagnostic for evaluation gastrointestinal symptoms from 33 centers were enrolled. Data including sex, age, endoscopic prospectively recorded. Totally 8892 included. At endoscopy, 4389,...
Previously a disease of the West and rarely seen in China, inflammatory bowel (IBD) is now increasing incidence China. However, its true unknown. The IBD Wuhan, major city central was investigated using population-based methods. A prospective, study conducted between January 1, 2010, December 31, 2010. New cases were identified by gastroenterologists from hospital case records 17 hospitals covering health care service Wuhan. Cases confirmed follow-up assessed specialist group every 3 months....
Salmonella enterica serovar Typhi is an important pathogen exclusively for humans and causes typhoid or enteric fever. It has been shown that type IVB pili, encoded by the S. pil operon located in pathogenicity island 7, are pathogenic process. In this study, using both adhesion-invasion assay fluorescence quantitative PCR analysis, we demonstrated entry of piliated A21-6 (pil(+) Km(r)) into human THP-1 monocytic cells was greater than a nonpiliated pilS::Km(r) (pil mutant) strain. We have...
Abstract Background and Aims Butyrate enemas have been shown to be effective in treatment of ulcerative colitis, but the mechanism effects butyrate is not totally known. This study evaluates topical sodium (NaB) 5-aminosalicylic acid (5-ASA) on expression trefoil factor 3 (TFF3), interleukin 1β (IL1β), nuclear κB (NFκB) trinitrobenzene sulphonic (TNBS) induced colitis rats. Methods Distal was male Wistar rats by colonic administration TNBS colonically treated with NaB, 5-ASA, combination NaB...
AIM: N -acetyltransferase 2 (NAT2) is an important enzyme catalyzing -acetylation of sulfasalazine (SASP). The aim the present study was to investigate associations genotypes NAT2 with inflammatory bowel disease (IBD), and adverse effects SASP, which used as first-line treatment IBD. PATIENTS AND METHODS: wildtype allele ( NAT2*4 ) three variant alleles NAT2*5B, NAT2*6A NAT*7B gene were determined in 101 patients IBD (84 ulcerative colitis 17 Crohn’s disease) 109 healthy controls by...
The etiology of inflammatory bowel disease (IBD) is not clear and cytomegalovirus (CMV) infection often associated with IBD patients. etiologic link between CMV needs to be studied. objective the present study investigate prevalence risk factors in a cohort patients from Central China.
Interleukin-23/T-helper 17 (IL-23/Th17) pathway plays a key role in the pathogenesis of inflammatory bowel disease (IBD), but little is known about its expression Chinese population. In this study, we investigated mRNA and protein levels IL-12p40, tumor necrosis factor-like cytokine 1A (TL1A), Janus kinase 2 (JAK2), IL-23R both locally systemically IBD patients. Our results indicated that IL-12p40 TL1A were increased ulcerative colitis (UC) Furthermore, serum higher active UC patients,...
Hyperhomocysteinaemia [HHcy] is a common phenomenon observed in patients with inflammatory bowel disease [IBD]. Homocysteine pro-inflammatory molecule and has been identified as risk factor for cardiovascular cerebral diseases. Whether HHcy contributes to the chronic inflammation of colon IBD rarely explored. The aim this study was investigate effect on dextran sulphate sodium [DSS]-induced colitis. Wistar rats were randomly divided into eight groups: [1] Control; [2] HHcy; [3] p38...
Helicobacter pylori is a major cause of chronic gastritis and peptic ulcer disease definite carcinogen for gastric adenocarcinoma. However, the underlying pathogenic mechanisms are not fully understood. Interleukin-1 (IL-1) key cytokine involved in H. pylori-induced inflammation. The present study aimed to determine polymorphisms IL-1B IL-1 receptor antagonist (IL-1RN) genes their association with infection gastroduodenal diseases Chinese patients.Three hundred ninety-nine patients (129...
The aim of the present study was to evaluate contribution dimorphism (MICA-129 val and met) genetic susceptibility functions ulcerative colitis (UC) in patients central China.Genotyping MICA-129 performed 272 consecutive UC 560 age- sex-matched healthy individuals by using a polymerase chain reaction-sequencing based typing (PCR-SBT) method. A total 93 98 serum soluble MICA (sMICA) concentrations were detected enzyme-linked immunosorbent assay.Both frequencies variant allele (val) genotype...
Inflammatory bowel diseases (IBD) result from complex interactions between environmental and genetic factors. Low blood levels of vitamin B12 folate variants related target enzymes are associated with IBD risk, in population studies. To investigate the underlying mechanisms, we evaluated effects a methyl-deficient diet (MDD, folate, choline) an experimental model colitis induced by dextran sodium sulphate (DSS), rat pups dams subjected to MDD during gestation lactation. Four groups were...
Alterations in tetraspanin CO-029 expression are associated with the progression and metastasis of cancers digestive system. However, how promotes cancer is still poorly understood. To determine mechanism, we silenced HT29 colon cells found that knockdown significantly reduced cell migratory ability. The diminished migration was accompanied by upregulation both integrin-dependent cell-matrix adhesion on laminin calcium-dependent cell-cell adhesion. surface levels laminin-binding integrin...
Regular colonoscopic surveillance for detection of dysplasia is recommended in longstanding inflammatory bowel disease (IBD), however, its sensitivity disputed. Screening accuracy may increase by using a biomarker-based strategy.A case-control study was performed to determine the prognostic value DNA ploidy and p53 IBD-related neoplasia. Cases with colorectal cancer (CRC), detected our program between 1985-2008, were selected matched two controls, age, gender, characteristics, interval...