A5100401457- Amyotrophic Lateral Sclerosis Research
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Nerve injury and regeneration
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Ion channel regulation and function
- Single-cell and spatial transcriptomics
- Atherosclerosis and Cardiovascular Diseases
Harbin Medical University
2020-2024
First Affiliated Hospital of Harbin Medical University
2020-2024
Abstract Ferroptosis is an iron-dependent cell death with the accumulation of lipid peroxidation and dysfunction antioxidant systems. As critical regulator, glutathione peroxidase 4 (GPX4) has been demonstrated to be down-regulated in amyotrophic lateral sclerosis (ALS). However, mechanism ferroptosis ALS remains unclear. In this research, bioinformatics analysis revealed a high correlation between ALS, ferroptosis, Speedy/RINGO cycle regulator family member A (SPY1). Lipid hSOD1G93A cells...
ANO1 is closely correlated with the activation of EGFR and CaMKII, while CaMKII show low in amyotrophic lateral sclerosis (ALS) models. Therefore, we designed experiments to verify that may play a protective role on motor neurons ALS by activating CaMKII.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder distinguished by gradual depletion of motor neurons. RNA binding motif protein 5 (RBM5), an abundantly expressed RNA-binding protein, plays critical role in the process cellular death. However, little known about RBM5 pathogenesis ALS. Here, we found that was upregulated ALS hSOD1
Abstract Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons. The exact mechanisms underlying neuron death in ALS are still not fully understood, but growing body evidence indicates that inflammatory could accentuate severity accelerate progression. Currently, no neuroprotective strategies have effectively prevented progression this disease. Methods : IF, western blotting RT-PCR were used...