A5034038157- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Neurogenetic and Muscular Disorders Research
- Mitochondrial Function and Pathology
- Atherosclerosis and Cardiovascular Diseases
- DNA and Nucleic Acid Chemistry
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Peroxisome Proliferator-Activated Receptors
- RNA and protein synthesis mechanisms
- Pluripotent Stem Cells Research
- Ion channel regulation and function
- Nerve injury and regeneration
- Immune cells in cancer
First Affiliated Hospital of Harbin Medical University
2020-2025
Harbin Medical University
2020-2025
Abstract Ferroptosis is an iron-dependent cell death with the accumulation of lipid peroxidation and dysfunction antioxidant systems. As critical regulator, glutathione peroxidase 4 (GPX4) has been demonstrated to be down-regulated in amyotrophic lateral sclerosis (ALS). However, mechanism ferroptosis ALS remains unclear. In this research, bioinformatics analysis revealed a high correlation between ALS, ferroptosis, Speedy/RINGO cycle regulator family member A (SPY1). Lipid hSOD1G93A cells...
Autophagic impairment has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Salt-inducible kinase 2 (SIK2), a member AMP-activated protein (AMPK) family widely expressed central nervous system, plays critical roles neuronal survival, neurogenesis, and regulation autophagy. This study aims to investigate effects underlying mechanisms SIK2 ALS. In our work, we used both vivo vitro models ALS effect SIK2. Protein RNA levels were assessed by Western blot, RT-qPCR,...
Abstract Objectives Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons (MN). CREB pathway‐mediated inhibition apoptosis contributes to neuron protection, and PAK4 activates signalling in diverse cell types. This study aimed investigate PAK4’s effect mechanism action ALS. Methods We analysed RNA levels qRT‐PCR, protein immunofluorescence Western blotting, flow cytometry TUNEL staining. Cell transfection was performed...
ANO1 is closely correlated with the activation of EGFR and CaMKII, while CaMKII show low in amyotrophic lateral sclerosis (ALS) models. Therefore, we designed experiments to verify that may play a protective role on motor neurons ALS by activating CaMKII.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder distinguished by gradual depletion of motor neurons. RNA binding motif protein 5 (RBM5), an abundantly expressed RNA-binding protein, plays critical role in the process cellular death. However, little known about RBM5 pathogenesis ALS. Here, we found that was upregulated ALS hSOD1
Abstract Background: The proto-oncogene c-Myb plays an important role in the proliferation of cells and its upregulation affects development glioblastomas. G-quadruplexes are secondary structures DNA or RNA that usually form promoter region oncogenes, including c-Myb, regulate expression these genes. traditional Chinese medicine brucine is a ligand located c-Myb. In this study, U87 cell line was used both vitro vivo to investigate therapeutic effect mechanism action brucine. Methods: MTT...
Abstract Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons. The exact mechanisms underlying neuron death in ALS are still not fully understood, but growing body evidence indicates that inflammatory could accentuate severity accelerate progression. Currently, no neuroprotective strategies have effectively prevented progression this disease. Methods : IF, western blotting RT-PCR were used...