A5027149233- Oral microbiology and periodontitis research
- Periodontal Regeneration and Treatments
- Dental Implant Techniques and Outcomes
- Immune Response and Inflammation
- Oral and gingival health research
- Salivary Gland Disorders and Functions
- Dental Radiography and Imaging
- Oral Health Pathology and Treatment
- Cell Adhesion Molecules Research
- Streptococcal Infections and Treatments
- Dental Health and Care Utilization
- Inflammasome and immune disorders
- Dental Education, Practice, Research
- interferon and immune responses
- Dental Trauma and Treatments
- NF-κB Signaling Pathways
- Dental Research and COVID-19
- Oral and Maxillofacial Pathology
- Inflammatory mediators and NSAID effects
- HIV/AIDS oral health manifestations
- Bone and Dental Protein Studies
- Phagocytosis and Immune Regulation
- dental development and anomalies
- Erythrocyte Function and Pathophysiology
- Cancer-related molecular mechanisms research
Peking University
2016-2025
Stomatology Hospital
2015-2025
National Clinical Research Center for Digestive Diseases
2020-2025
Southern University of Science and Technology
2025
King University
2024
In-Q-Tel
2014
Chungnam National University
2007
Capital Medical University
1999-2000
Significant effort has been devoted to fabricating various biomaterials satisfy specific clinical requirements. In this study, we developed a new type of guided tissue regeneration (GTR) membrane by electrospinning suspension consisting poly(l-lactic acid), multiwalled carbon nanotubes, and hydroxyapatite (PLLA/MWNTs/HA). MWNTs/HA nanoparticles were uniformly dispersed in the membranes, degradation characteristics far improved. Cytologic research revealed that PLLA/MWNTs/HA enhanced adhesion...
Concentrated growth factor (CGF), a new generation of platelet concentrate product, appears to have more abundant factors because its special centrifugation process. However, there are few studies supporting this. This study was designed evaluate the contents major in CGF and compare them with those found PRP (platelet-rich plasma) PRF fibrin). PRP, PRF, were obtained from same samples peripheral blood. Concentrations five representative platelets measured enzyme-linked immunosorbent assay...
Dental healthcare workers (DHCWs) are at high risk of occupational exposure to droplets and aerosol particles emitted from patients' mouths during treatment. We evaluated the effectiveness an air cleaner in reducing droplet contamination by positioning device four different locations actual dental clinic. applied computational fluid dynamics (CFD) methods solve governing equations airflow, energy dispersion different-sized airborne droplets/aerosol particles. In a clinic, we measured supply...
NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, has been reported to participate in inflammasome formation. Activation triggers caspase-1–dependent programming cell death called pyroptosis. However, whether NLRP6 induces pyroptosis not investigated. In this study, we showed that overexpression activated caspase-1 and gasdermin-D then induced human gingival fibroblasts, resulting release proinflammatory mediators...
To investigate the regenerative effect of adjunctive use guided tissue regeneration (GTR), bovine porous bone mineral (BPBM), and platelet-rich fibrin (PRF) in intrabony defects.Fourteen participants were enrolled, for each patient their left right two sides randomized to test group or control group. Only worst defect on side was analyzed. The received GTR, BPBM, PRF, whereas only GTR BPBM. PRF used trial fluid which combined with BPBM form a BPBM-PRF complex. patients followed up by...
Background Platelet-rich plasma (PRP) is a kind of natural source autologous growth factors, and has been used successfully in medical community. However, the effect PRP periodontal regeneration not clear yet. This study was designed to evaluate effectiveness as an adjunct bovine porous bone mineral (BPBM) graft treatment human intrabony defects. Methods Seventeen defects 10 periodontitis patients were randomly treated either with BPBM (test group, n=9) or alone (control n=8). Clinical...
Porphyromonas gingivalis has been shown to actively invade endothelial cells and induce vascular cell adhesion molecule 1 (VCAM-1) intercellular (ICAM-1) overexpression. Nucleotide-binding oligomerization domain (NOD1) is an intracellular pattern recognition reporter, its involvement in this process was unknown. This study focused on infected with P. gingivalis, the detection of NOD1 expression role that plays upregulation VCAM-1 ICAM-1.The human umbilical vein line (ECV-304) intruded by...
The mechanism by which Porphyromonas gingivalis regulates intracellular adhesion molecule 1 (ICAM-1) expression in human periodontal ligament cells (hPDLCs) and gingival fibroblasts (hGFs) is unknown. aim of this study to investigate whether nucleotide binding oligomerization domain-containing protein (NOD) NOD2 are involved process the clinical significance ICAM-1 periodontitis.hPDLCs hGFs were treated with P. gingivalis, l-Ala-γ-d-glutamyl-mesodiaminopimelic acid (an agonist for NOD1),...
Abstract Periodontitis is a chronic periodontal inflammatory disease caused by pathogens commonly seen in adults. Eupalinolide B (EB) sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as potential drug for cancers immune disorders. Here, we explored the ameliorative effects underlying molecular mechanism of EB on periodontitis first time. We demonstrated that ameliorates inflammation alveolar bone resorption with ligated mouse model. In addition,...
To compare the clinical, esthetic, and patient-reported outcomes of vestibular incision subperiosteal tunnel access (VISTA) technique modified (mTunnel) technique, both combined with connective tissue grafts (CTGs), for treating recession type 1 (RT1) single gingival recessions. A total 24 patients non-molar RT1 recessions were randomly assigned to VISTA + CTG or mTunnel group. blinded examiner assessed reduction (RecRed), mean root coverage (MRC), complete (CRC), keratinized width,...
Abstract Background This study evaluated the efficacy of concentrated growth factor (CGF) sticky bone combined with guided tissue regeneration (GTR) in treating shallow infrabony defects and explored factors influencing clinical outcomes. Methods Thirteen patients 31 (≤3 mm) were treated using CGF (CGF + deproteinized bovine mineral), covered a collagen membrane membrane. Probing depth (PD), attachment level (CAL), gingival recession (REC) examined at baseline 1 year post surgery. The...
Smoking is considered a significant risk factor for both periodontal disease and cardiovascular (CVD). Endothelial cells play an important role in the progression of diseases. In present study, we investigated vitro impact nicotine on functional properties human umbilical vein endothelial (HUVECs) stimulated with lipopolysaccharide (LPS) pathogen Porphyromonas gingivalis. HUVECs were different concentrations (10 µM-10 mM) and/or P. gingivalis LPS. Expression levels intercellular adhesion...
Porphyromonas gingivalis (P. gingivalis) is one of the main periodontal bacteria. This pathogen was reported to enhance monocyte migration and adhesion endothelial cells in atherosclerosis. The scavenger receptor lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays a pivotal role atherogenesis. aim this study investigate whether LOX-1 modulates P. gingivalis-mediated how it works. results showed that monocytic THP-1 human umbilical vein (HUVECs) were significantly enhanced...
Summary P orphyromonas gingivalis , an important periodontal pathogen, has been proved to actively invade cells, induce endothelial cell activation, and promote development of atherosclerosis. Innate immune surveillance, which includes the activity nucleotide‐binding oligomerization domain ( NOD )‐like receptors NLR s) Toll‐like TLR s), are essential for control microbial infections; however, roles receptor families in . infections remain unclear. Here, we examined s activation caused by...
Abstract Correlation between periodontitis and atherosclerosis is well established, the inherent mechanisms responsible for this relationship remain unclear. The biological function of growth arrest‐specific 6 (gas6) has been discovered in both inflammation. Inhibitory effects gas6 on expression inflammatory factors human umbilical vein endothelial cells (HUVECs) stimulated by Porphyromonas gingivalis lipopolysaccharide ( P. ‐LPS) were reported our previous research. Herein,...
Background: Partial‐mouth periodontal examination (PMPE) has been widely used in epidemiologic studies. In this study, the authors evaluate accuracy of extent and severity estimates from PMPE protocols a Chinese population. Methods: The study enrolled 200 individuals with periodontitis, ages 22 to 64 years. Full‐mouth was performed determine probing depth (PD), attachment loss (AL), bleeding on (BOP) at mesio‐buccal (MB), mid‐buccal (B), disto‐buccal (DB), mesio‐lingual (ML), mid‐lingual...