A5009390799- RNA modifications and cancer
- Analytical chemistry methods development
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Aquaculture disease management and microbiota
- Electrochemical Analysis and Applications
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Zebrafish Biomedical Research Applications
- Hydrocarbon exploration and reservoir analysis
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Berberine and alkaloids research
- Fungal and yeast genetics research
- Effects and risks of endocrine disrupting chemicals
- Traditional Chinese Medicine Analysis
- Inflammasome and immune disorders
- Andrographolide Research and Applications
- Medical Imaging and Analysis
- Machine Learning in Healthcare
- Air Quality Monitoring and Forecasting
- Physiological and biochemical adaptations
- Congenital heart defects research
- Time Series Analysis and Forecasting
Jiaxing University
2020-2024
Tianjin University
2022-2023
Wenzhou Medical University
2015-2023
Guangzhou University of Chinese Medicine
2021-2023
Shanghai University of Traditional Chinese Medicine
2021-2023
Guangzhou University
2019-2023
Zhejiang Medicine (China)
2020-2023
Lingnan Normal University
2023
Beijing University of Chemical Technology
2021-2023
Chengdu University of Technology
2022
Abstract Background Although EGFR-TKI resistance mechanisms in non-small cell lung cancer (NSCLC) have been extensively studied, certain patient subgroups remain with unclear mechanisms. This retrospective study analysed mutation data of NSCLC patients EGFR -sensitive mutations and high programmed death-ligand 1 (PD-L1) expression or TMB to identify primary Methods Hybrid capture-based next-generation sequencing (NGS) was used analyse 639 genes tumor tissues blood samples from 339 patients....
Several studies have linked impaired glucose uptake and insulin resistance (IR) to functional impairment of the heart. Recently, endocannabinoids been implicated in cardiovascular disease. However, mechanisms involving endocannabinoid signaling, uptake, IR cardiomyocytes are understudied. Here we report that 2-arachidonoylglycerol (2-AG), via stimulation cannabinoid type 1 (CB1) receptor Ca2+/calmodulin-dependent protein kinase β, activates AMP-activated (AMPK), leading increased uptake....
A recent study has reported that patients with nonalcoholic fatty liver disease (NAFLD) are more susceptible to coronary microvascular dysfunction (CMD), which may predict major adverse cardiac events. However, little is known regarding the causes of CMD during NAFLD. In this study, we aimed explore role hepatic small extracellular vesicles (sEVs) in regulating endothelial microvessels NAFLD.We established two murine NAFLD models by feeding mice a methionine-choline-deficient (MCD) diet for...
Berberine has received rising attention for its application in cardiovascular disease because of relationship with inflammation. The endothelial NLRP3 inflammasome triggers inflammatory vascular injury which would lead to disease. Endothelial calcium signalling plays a crucial role both the activation and cells dysfunction. However, efficacy BBR on remains unknown.In this study, we focused pathway determine whether regulates junction function injury.The integrity proteins VE-cadherin (VEC)...
Abstract It remains challenging to construct a complete cell lineage map of the origin vascular endothelial cells in any vertebrate embryo. Here, we report application toto light-sheet fluorescence imaging embryos trace (ECs) at single-cell resolution zebrafish. We first adapted previously reported method embryo mounting and imaging, created an alignment, fusion, extraction all-in-one software (AFEIO) for processing big data, performed quantitative analysis relationships using commercially...
Danhong injection (DHI), which is a Chinese clinical prescription consists of Radix et Rhizoma Salviae Miltiorrhizae (Salvia miltiorrhiza Bge., Labiatae, Danshen in Chinese) and Flos Carthami (Carthamus tinctorius L., Compositae, Honghua Chinese)(Plant names have been checked with http://www.theplantlist.org on March 1st, 2022), has mainly used the therapy cardiovascular diseases, including hypertension China for many years.Cardiovascular diseases (CVDs) are major causes death all around...
While precision oncology requires robust biomarkers, current predictors for lung adenocarcinoma (LUAD) often show limited clinical utility. This study investigates the multifaceted roles of ZC3H12D, a novel immunomodulatory molecule, in LUAD progression and tumor microenvironment regulation. Multi-omics analyses integrated ZC3H12D transcriptomic (511 tumors vs 59 normals), proteomic (74 69 single-cell RNA-seq data (15 11 normals). Immunohistochemistry validated expression 51 matched pairs....
Introduction Epidermal growth factor receptor 2 ( HER2 ) and programmed cell death ligand 1 (PD-L1) are pivotal therapeutic targets for advanced gastric cancer (GC). Nevertheless, the correlation between them, along with clinical genomic characteristics prognosis differences across distinct molecular subtypes, remains elusive. Methods In this retrospective study, 390 GC patients provided both tumor tissue paired blood samples Next-Generation Sequencing (NGS) of 639 tumor-related genes, PD-L1...
This present study examined the effect of Tamibarotene (AM80) in APP/PS1 mice, a well-established AD mouse model. AM80 was intraperitoneal administered to 3-month-old mice at dose 5 mg/kg/day for 16 weeks. The results clearly showed that could reduce amyloid-β peptides through impact on APP processing and microglia astrocyte activation mice. most notable finding inhibitory BACE1 mediated by NF-κB pathway underlies anti-inflammatory action AM80. Moreover, significantly decrease synaptic loss...
Abstract Background Bronchopulmonary Dysplasia (BPD) has a high incidence and affects the health of preterm infants. Cuproptosis is novel form cell death, but its mechanism action in disease not yet clear. Machine learning, latest tool for analysis biological samples, still relatively rarely used in-depth prediction diseases. Methods results First, differential expression cuproptosis-related genes (CRGs) GSE108754 dataset was extracted heat map showed that NFE2L2 gene significantly higher...
Purpose Loss-of-function mutations in the adenomatous polyposis coli (<i>APC</i>) gene are common metastatic colorectal cancer (mCRC). However, characteristic of <i>APC</i> specific mCRC is poorly understood. Here, we explored clinical and molecular characteristics N-terminal C-terminal side APC Chinese patients with mCRC.Materials Methods Hybrid capture-based next-generation sequencing was performed on tumor tissues from 275 pati-ents to detect 639 tumor-associated...
Abstract SH3 domain‐binding kinase 1 (SBK1), is a member of the serine/threonine protein kinases family, and was confirmed to be upregulated in cervical cancer our previous study. Nonetheless, role SBK1 regulating occurrence development unclear. In this study, stable SBK1‐knockdown ‐overexpressed cell models were constructed by plasmid transfection technology. Cell viability growth assessed through CCK‐8, colony formation, BrdU methods. cycle apoptosis analyzed flow cytometry. The JC‐1...
Abstract Objectives Ferroptosis is a unique process of cell death that specifically requires iron. We investigated ferroptosis genes and their function in lung adenocarcinoma (LUAD) patients. Methods Data on the expression levels associated with were collected from FerrDb Cancer Genome Atlas database. Kaplan-Meier Plotter was employed to generate survival curves LUAD patients high vs low genes. The relationship between immune infiltration analyzed via TIMMER. Immunohistochemical staining...
Atherosclerosis is a chronic inflammatory disease of medium and large vessels typically characterized by the predominant accumulation low-density lipoprotein (LDL)-cholesterol inside macrophages that reside in vessel walls. Previous studies clearly demonstrated an association specifically between oxidized type LDL (oxLDL) atherosclerotic lesion formation. Further observations revealed these lesions displayed enlarged, lipid-loaded lysosomes. By increasing natural antibodies against oxLDL,...