A5044112969- Cancer, Lipids, and Metabolism
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Histone Deacetylase Inhibitors Research
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Immune cells in cancer
- Immune Cell Function and Interaction
- Childhood Cancer Survivors' Quality of Life
- Pericarditis and Cardiac Tamponade
- Cancer Immunotherapy and Biomarkers
- Cardiovascular Syncope and Autonomic Disorders
- Neurogenetic and Muscular Disorders Research
- Lipid metabolism and biosynthesis
- Autoimmune and Inflammatory Disorders Research
- Genomics and Chromatin Dynamics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sarcoidosis and Beryllium Toxicity Research
- Blood Pressure and Hypertension Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Psychosomatic Disorders and Their Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
- Ultrasound in Clinical Applications
- Neonatal Health and Biochemistry
University of Milan
2009-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2023-2024
Ospedale Maggiore
2009-2024
Cancer Genetics (United States)
2019-2022
Columbia University
2019-2022
Columbia University Irving Medical Center
2019
Humanitas University
2017
University of Bergamo
2017
Ospedale Papa Giovanni XXIII
2015-2016
Abstract Chromosomal rearrangements are initiating events in acute lymphoblastic leukaemia (ALL). Here using RNA sequencing of 560 ALL cases, we identify between MEF2D (myocyte enhancer factor 2D) and five genes ( BCL9 , CSF1R DAZAP1 HNRNPUL1 SS18 ) 22 B progenitor (B-ALL) cases with a distinct gene expression profile, the most common which is MEF2D-BCL9 . Examination an extended cohort 1,164 B-ALL identified 30 rearrangements, include additional fusion partner, FOXJ2 ; thus, MEF2D-...
Neutrophils are a component of the tumor microenvironment and have been predominantly associated with cancer progression. Using genetic approach complemented by adoptive transfer, we found that neutrophils essential for resistance against primary 3-methylcholantrene-induced carcinogenesis. were activation an interferon-γ-dependent pathway immune resistance, polarization subset CD4- CD8- unconventional αβ T cells (UTCαβ). Bulk single-cell RNA sequencing (scRNA-seq) analyses unveiled...
Spinal muscular atrophy, characterized by selective loss of lower motor neurons, is an incurable genetic neurological disease leading to infant mortality. We previously showed that primary neural stem cells derived from spinal cord can ameliorate the atrophy phenotype in mice, but this source has limited translational value. Here, we illustrate pluripotent embryonic show same potential therapeutic effects as those and offer great promise unlimited for transplantation. found cell-derived...
Highlights•Minimal residual disease positivity in acute lymphoblastic leukemia is a major risk factor for relapse and poor outcomes•We evaluated the impact of minimal levels before allogeneic hematopoietic stem cell transplantation on outcomes patients with Philadelphia chromosome–positive leukemia•Patients measurable have higher relapse•Achieving negativity should be prerequisite successful transplantationAbstractAllogeneic (alloHSCT) first complete remission (CR1) remains consolidation...
Abstract Early T-cell acute lymphoblastic leukemia (ETP-ALL) is an aggressive hematologic malignancy associated with early relapse and poor prognosis that genetically, immunophenotypically, transcriptionally distinct from more mature (T-ALL) tumors. Here, we leveraged global metabolomic transcriptomic profiling of primary ETP- T-ALL samples to identify specific metabolic circuitries differentially active in this high-risk group. ETP-ALLs showed increased biosynthesis phospholipids...
Long-range enhancers govern the temporal and spatial control of gene expression; however, mechanisms that regulate enhancer activity during normal malignant development remain poorly understood. Here, we demonstrate a role for aberrant chromatin accessibility in regulation MYC expression T-cell lymphoblastic leukemia (T-ALL). Central to this process, NOTCH1-MYC (N-Me), long-range T cell-specific enhancer, shows dynamic changes specification maturation an high degree mouse human T-ALL cells....
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a fatal form of infantile motoneuron disease. There currently no effective treatment, although motor neuron replacement possible therapeutic strategy. We transplanted purified neurons into the spinal cord nmd mice, an animal model SMARD1. also administered pharmacological treatment targeting induction axonal growth toward skeletal muscle target. At end stage disease, donor-derived were detected in anterior horns, extended...
Syncope is a common condition encountered in the emergency department (ED), accounting for about 0.6-3% of all ED visits. Despite its high frequency, widely accepted management strategy patients with syncope still missing. Since can be presenting many diseases, both severe and benign, most research efforts have focused on strategies to obtain definitive etiologic diagnosis. Nevertheless, everyday clinical practice, diagnosis rarely reached after first evaluation. It thus troublesome aid...
<div>Abstract<p>Early T-cell acute lymphoblastic leukemia (ETP-ALL) is an aggressive hematologic malignancy associated with early relapse and poor prognosis that genetically, immunophenotypically, transcriptionally distinct from more mature (T-ALL) tumors. Here, we leveraged global metabolomic transcriptomic profiling of primary ETP- T-ALL samples to identify specific metabolic circuitries differentially active in this high-risk group. ETP-ALLs showed increased biosynthesis...
<div>Abstract<p>Early T-cell acute lymphoblastic leukemia (ETP-ALL) is an aggressive hematologic malignancy associated with early relapse and poor prognosis that genetically, immunophenotypically, transcriptionally distinct from more mature (T-ALL) tumors. Here, we leveraged global metabolomic transcriptomic profiling of primary ETP- T-ALL samples to identify specific metabolic circuitries differentially active in this high-risk group. ETP-ALLs showed increased biosynthesis...
Supplementary Data from Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
Supplementary Data from Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
Supplementary Data from Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
Supplementary Data from Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
Supplementary Data from Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
Supplementary Data from Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia