A5047998657- Mathematical and Theoretical Epidemiology and Ecology Models
- Fractional Differential Equations Solutions
- COVID-19 epidemiological studies
- Evolution and Genetic Dynamics
- Bone Metabolism and Diseases
- Nonlinear Differential Equations Analysis
- Estrogen and related hormone effects
- Viral Infections and Vectors
- Bone health and osteoporosis research
- Iterative Methods for Nonlinear Equations
- Differential Equations and Numerical Methods
- SARS-CoV-2 and COVID-19 Research
- Bone health and treatments
- HIV Research and Treatment
- Mathematical Biology Tumor Growth
- Numerical methods for differential equations
- Growth Hormone and Insulin-like Growth Factors
- Immune Cell Function and Interaction
- Research on Leishmaniasis Studies
- Nanofluid Flow and Heat Transfer
- Numerical methods in engineering
- Advanced Control Systems Design
- Mathematics and Applications
- Fibroblast Growth Factor Research
- Lipid metabolism and biosynthesis
University of Malakand
2014-2024
University of Balochistan
2019
Jiangsu University
2017
University of Jordan
2016
University of London
1999-2015
Royal Veterinary College
2001-2013
Universidad de Londres
2012
University of the Sciences
2011
National University of Sciences and Technology
2009-2010
Pusan National University
2007-2008
The deadly coronavirus continues to spread across the globe, and mathematical models can be used show suspected, recovered, deceased patients, as well how many people have been tested. Researchers still do not know definitively whether surviving a COVID-19 infection means you gain long-lasting immunity and, if so, for long? In order understand, we think that this study may lead better guessing of pandemic in future. We develop model present dynamical behavior by incorporating isolation...
The Wnt/beta-catenin pathway has been implicated in bone cell response to their mechanical environment. This is the origin of mechanism by which cells adjust architecture maintain strength. Osteoporosis most widespread failure this mechanism. degree osteoporotic loss men and women related bio-available estrogen. Here we report that osteoblastic ROS 17/2.8 primary osteoblast cultures, a single short period dynamic strain, as well glycogen synthase kinase-3beta (GSK-3beta) inhibitor LiCl,...
Abstract Previous studies have indicated that physiological levels of dynamic mechanical strain produce rapid increases in nitric oxide (NO) release from rat ulna explants and primary cultures osteoblast-like cells embryonic chick osteocytes derived long bones. To establish the mechanism by which loading-induced NO production may be regulated, we examined: synthase (NOS) isoform mRNA protein expression, effect loading vivo on NOS bone culture. Using Northern blot analyses, situ...
In this paper, taking fractional derivative due to Caputo and Fabrizo, we have investigated a biological model of smoking type. By using Sumudu transform Picard successive iterative technique, develop the solutions for considered model. Furthermore, some results related uniqueness equilibrium solution its stability are discussed utilizing techniques nonlinear functional analysis. The dynamics various compartments plotted with help Matlab.
The role of mechanical strain and estrogen status in regulating ERalpha levels bone cells was studied female rats. OVX is associated with decreased protein expression/osteocyte, whereas habitual artificial loading has only a small but positive effect, except on the ulna's medial surface, where stimulates reversal resorption to formation.Osteoporosis most widespread failure bones' ability match their architectural strength load bearing. In men women, severity loss bioavailability estrogen....
Postmenopausal osteoporosis represents a failure of the response by which bone cells adapt mass and architecture to be sufficiently strong withstand loading without fracture. To address why this should associated with oestrogen withdrawal, we investigated ulna's adaptive mechanical in adult female mice lacking receptor-alpha (ERalpha(-/-)), those receptor-beta (ERbeta(-/-)) their wild-type littermates. In mice, short periods physiologic cyclic compressive ulna vivo over 2-week period...
Sclerostin is a potent inhibitor of bone formation which down‐regulated by mechanical loading. To investigate the mechanisms involved we subjected Saos2 human osteoblastic cells to short periods dynamic strain and used quantitative reverse transcriptase polymerase chain reaction compare their responses unstrained controls. Strain‐induced Sost down‐regulation was recapitulated cyclo‐oxygenase‐2‐mediated PGE2, acting through EP4 receptor, whereas strain‐related up‐regulation osteocalcin...
The present study shows no adverse effects of the anti-diabetic drug metformin on bone mass and fracture healing in rodents but demonstrates that is not osteogenic vivo, as previously proposed. In view increased incidence fractures patients with type 2 diabetes mellitus (T2DM), we investigated metformin, a widely used T2DM therapy, vivo using two different rodent models modes administration. We first subjected 12-week-old female C57BL/6 mice to ovariectomy (OVX). Four weeks after OVX,...
Abstract Bone cells' early responses to estrogen and mechanical strain were investigated in the ROS 17/2.8 cell line. Immunoblotting with antiphosphorylated receptor α (ER-α) antibody showed that when these cells exposed for 10 minutes (10−8 M) or a single period of cyclic dynamic (peak 3400 μϵ, 1Hz, 600 cycles), there was an increase intensity 66-kDa band, indicating phosphorylation ser122 amino terminus ER-α. Increased detected within 5 exposure after end strain. Estrogen also activated...
Loading-related changes in gene expression resident cells the tibia of female mice contexts normality (WT), estrogen deficiency (WT-OVX), absence receptor alpha (ERalpha(-/-)) and disuse due to sciatic neurectomy (WT-SN) were established by microarray. Total RNA was extracted from loaded contra-lateral non-loaded tibiae at selected time points after a single, short period dynamic loading sufficient engender an osteogenic response. There marked many genes according context as well response...
Mechanical loading of bone explants stimulates prostaglandin E2 (PGE2) and prostacyclin (PGI2) release increases glucose 6-phosphate dehydrogenase (G6PD) activity. This response is blocked by indomethacin imitated exogenous PGs. In the experiments reported here, primary cultures rat long bone-derived osteoblast-like cells were exposed to a dynamic strain PGs in culture dish. Strain (3400 mu epsilon, 600 cycles, 1 Hz) caused an immediate PGI2 into medium but had no effect on PGE2. also...
Abstract Osteoblast-like cells in primary cultures derived from ERα−/− mice do not proliferate response to mechanical strain, unlike those their ERα+/+ littermates. also lack strain-related NO production and responsiveness IGFs. Proliferative strain is rescued by transfection with functional ERα. ERα number or function bone may limit bones' adaptability loading. Introduction: In vivo, osteogenic loading involves proliferation of surface osteoblasts. This replicated vitro ERK-mediated...