A5056602278- HIV-related health complications and treatments
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Urinary Bladder and Prostate Research
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Cervical Cancer and HPV Research
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- HIV Research and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pelvic floor disorders treatments
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Arrhythmias and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Systemic Lupus Erythematosus Research
- Hemoglobinopathies and Related Disorders
- Hemodynamic Monitoring and Therapy
- HIV/AIDS Research and Interventions
SUNY Downstate Health Sciences University
2016-2025
State University of New York
2016-2025
University of California, San Francisco
2014-2023
North Shore University Hospital
2023
North Bristol NHS Trust
2023
Southmead Hospital
2023
Emory University
2020-2023
Ghent University
2023
Vanderbilt University Medical Center
2023
University of Alberta
2020
To assess the association of HIV infection, disease parameters (including CD4+ T-cell counts, viral load, and AIDS) antiretroviral medication use with subclinical carotid artery atherosclerosis.Cross-sectional study nested within a prospective cohort study.Among participants in Women's Interagency Study (1331 HIV-infected women, 534 HIV-uninfected women) Multicenter AIDS Cohort (600 men, 325 men), we measured lesions common intima-media thickness using B-mode ultrasound. We estimated...
Highly active antiretroviral therapy (HAART), in addition to traditional vascular risk factors, may affect coronary heart disease (CHD) individuals with human immunodeficiency virus (HIV) infection.Among HIV-infected (931 men and 1455 women) HIV-uninfected (1099 576 adults, the predicted of CHD was estimated on basis age, sex, lipid blood pressure levels, presence diabetes, smoking status.Among men, 2% had moderate (10-year risk, 15%-25%), 17% high > or = 25% diabetes). Among women, 12%...
Background. Individuals infected with human immunodeficiency virus (HIV) live longer as a result of effective treatment, but long-term consequences infection, and immunological dysfunction are poorly understood. Methods. We prospectively examined 1011 women (74% HIV-infected) in the Women's Interagency HIV Study 811 men (65% Multicenter AIDS Cohort who underwent repeated B-mode carotid artery ultrasound imaging 2004–2013. Outcomes included changes right common intima-media thickness...
Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection. We examined 778 women (74% HIV+) the Women's Interagency HIV Study 503 men (65% Multicenter AIDS Cohort who underwent repeated B-mode carotid artery ultrasound imaging 2004–2013. assessed baseline associations of serum macrophage markers soluble (s)CD163, sCD14, galectin-3 (Gal-3), Gal-3...
Abstract Background African-Americans/Blacks have suffered higher morbidity and mortality from COVID-19 than all other racial groups. This study aims to identify the causes of this health disparity, determine prognostic indicators, assess efficacy treatment interventions. Methods We performed a retrospective cohort clinical features laboratory data patients admitted over 52-day period at height pandemic in United States. was an urban academic medical center New York City, declared COVID-only...
Infection with hepatitis C virus (HCV) or human immunodeficiency (HIV) may be associated atherosclerosis and vascular disease. Macrophages are a major component of atherosclerotic plaque, classically activated (M1) macrophages contribute to plaque instability. Our goal was identify plasma biomarkers that reflect macrophage inflammation subclinical atherosclerosis. We tested whether M1 produce galectin-3-binding protein in vitro. Then, we measured the soluble cluster differentiation (CD) 163...
It is unknown whether disrupted tryptophan catabolism associated with cardiovascular disease (CVD) in human immunodeficiency virus (HIV)–infected individuals. Plasma and kynurenic acid were measured 737 women men (520 HIV+, 217 HIV−) from the Women's Interagency HIV Study Multicenter AIDS Cohort Study. Repeated B-mode carotid artery ultrasound imaging was obtained 2004 through 2013. We examined associations of baseline tryptophan, acid, acid-to-tryptophan (KYNA/TRP) ratio, risk plaque. After...
Alterations in gut microbiota and blood metabolomic profiles have been implicated HIV infection cardiovascular disease. However, it remains unclear whether alterations may contribute to disrupted host relation atherosclerosis, especially the context of infection. We analyzed cross-sectional associations between features carotid artery plaque 361 women with or at high risk (67% HIV+), further integrated plaque-associated microbial plasma lipidomic/metabolomic profiles. Furthermore, 737 men,...
Abstract Background Alterations in gut microbiota have been implicated HIV infection and cardiovascular disease. However, how microbial alterations relate to host inflammation metabolite profiles, their relationships with atherosclerosis, not well-studied, especially the context of infection. Here, we examined associations species functional components measured by shotgun metagenomics carotid artery plaque assessed B-mode ultrasound 320 women or at high risk (65% +) from Women’s Interagency...
People living with HIV (PLWH) experience increased vulnerability to premature aging and inflammation-associated comorbidities, even when replication is suppressed by antiretroviral therapy (ART). However, the factors associated this remain uncertain. In general population, alterations in N-glycans on IgGs trigger inflammation precede onset of aging-associated diseases. Here, we investigate IgG cross-sectional longitudinal samples from 1214 women men, without HIV. PLWH exhibit an accelerated...
Summary Purpose: Autonomic consequences of seizures are common, but can be severe. We sought to define changes in autonomic activity from limbic cortical and their impact on the heart. Methods: studied kainic acid (KA)‐induced urethane‐anesthetized rats using peripheral nerve, blood pressure (BP), ECG recordings echocardiography. Results: Seizures were associated with massive increases parasympathetic (vagus nerves) sympathetic (cervical ganglion >renal nerve >splanchnic nerve)...
Individuals with human immunodeficiency virus (HIV) who use highly active antiretroviral therapy (HAART) may have an increased risk for cardiovascular-related events, although the underlying mechanism remains unclear. We tested hypothesis that carotid arterial stiffness was higher among persons using HAART compared to HAART-naïve and HIV-uninfected persons.Between 2004 2006, we performed high-resolution B-mode ultrasound on 2789 HIV-infected participants of Women's Interagency HIV Study...
The authors determined if E-point septal separation (EPSS) as measured by junior emergency physicians (EPs) correlated with visual estimation of left ventricle ejection fraction (LVEF) senior EPs and cardiologists in acutely dyspneic patients presenting to an adult department (ED).Acutely were enrolled a prospective, observational study. EPSS was using bedside ultrasonography (PGY 3 PGY 4 residents) variable ultrasound experience. M-mode measurements recorded the parasternal long-axis...
Objectives: Prevalence of microalbuminuria is increased in patients with HIV. Microalbuminuria associated mortality other populations, including diabetics, for whom testing standard care. We investigated whether HIV-infected women not receiving antiretroviral therapy. Methods: Urinalysis proteinuria and semiquantitative were performed specimens from 2 consecutive visits 1547 enrolled the Women's Interagency HIV Study 1994-1995. Time to death was modeled using proportional hazards analysis....
Background: Inflammation and hemostasis perturbation may be involved in vascular complications of HIV infection. We examined atherogenic biomarkers subclinical atherosclerosis HIV-infected adults before after beginning highly active antiretroviral therapy (HAART). Methods: In the Women's Interagency Study, 127 women studied pre post HAART were matched to HIV-uninfected controls. Six semiannual measurements soluble CD14, tumor necrosis factor (TNF) alfa, interleukin (IL) 2 receptor, IL-6,...
We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated an increased risk in (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P .01). TMAO positively correlated biomarkers monocyte activation inflammation (sCD14, sCD163)....
Abstract Background: Effective screening for oropharyngeal cancer is lacking. Four oncogenic HPV clearance definitions were explored to understand long-term natural history persistent oral (oncHPV), the precursor of cancer. Methods: Prospective multicenter cohort participants living with/at-risk HIV, with rinse and gargle samples collected every 6 12 months up 10 years tested oncHPV. included 1 (clear1), 2 (clear2), 3 (clear3) consecutive negatives, or being negative at last two visits...