A5017230513- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- HIV-related health complications and treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and Carotid Artery Diseases
- Tryptophan and brain disorders
- Diet and metabolism studies
- Neuroethics, Human Enhancement, Biomedical Innovations
- vaccines and immunoinformatics approaches
- Cancer-related gene regulation
- Breast Cancer Treatment Studies
- Cholesterol and Lipid Metabolism
- Metabolism and Genetic Disorders
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Sleep and Wakefulness Research
- Radiomics and Machine Learning in Medical Imaging
- Intracranial Aneurysms: Treatment and Complications
- Ethics in Clinical Research
- Gastrointestinal motility and disorders
- Neutropenia and Cancer Infections
- Neurological Complications and Syndromes
Clemson University
2025
Saint Louis University Hospital
2024
Integra (United States)
2023
Broad Institute
2016-2020
Massachusetts Institute of Technology
2017-2018
Albert Einstein College of Medicine
2018
Harvard University
2017-2018
Centers for Disease Control and Prevention
2011
The discovery of cancer dependencies has the potential to inform therapeutic strategies and identify putative drug targets. Integrating data from comprehensive genomic profiling cell lines functional characterization dependencies, we discovered that loss enzyme methylthioadenosine phosphorylase (MTAP) confers a selective dependence on protein arginine methyltransferase 5 (PRMT5) its binding partner WDR77. MTAP is frequently lost due proximity commonly deleted tumor suppressor gene, CDKN2A....
Age-related macular degeneration (AMD) is the major cause of blindness in developed nations. AMD characterized by retinal pigmented epithelial (RPE) cell dysfunction and loss photoreceptor cells. Epidemiologic studies indicate important contributions dietary patterns to risk for AMD, but mechanisms relating diet disease remain unclear. Here we investigate effect on isocaloric diets that differ only type carbohydrate a wild-type aged-mouse model. The consumption high-glycemia (HG) resulted...
Background: Although metabolomic profiling offers promise for the prediction of coronary heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in women than men, limited data available women. Methods: We applied a liquid chromatography–tandem mass spectrometry metabolomics platform to measure 371 metabolites discovery set postmenopausal (472 incident cases, 472 controls) validation an independent (312 315 controls). Results: Eight metabolites, primarily...
Bacterial urease activity of the gut microbiota alters nitrogen flux, leading to dysbiosis and worsening colitis in mice.
Unbiased, "nontargeted" metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack successful applications to human disease. By integrating nontargeted metabolomics, genetics, detailed phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent CT-defined nonalcoholic fatty liver disease (NAFLD) offspring cohort Framingham Heart Study (FHS) participants. We verified relationship between DMGV early hepatic...
It is unknown whether disrupted tryptophan catabolism associated with cardiovascular disease (CVD) in human immunodeficiency virus (HIV)–infected individuals. Plasma and kynurenic acid were measured 737 women men (520 HIV+, 217 HIV−) from the Women's Interagency HIV Study Multicenter AIDS Cohort Study. Repeated B-mode carotid artery ultrasound imaging was obtained 2004 through 2013. We examined associations of baseline tryptophan, acid, acid-to-tryptophan (KYNA/TRP) ratio, risk plaque. After...
We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated an increased risk in (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P .01). TMAO positively correlated biomarkers monocyte activation inflammation (sCD14, sCD163)....
Epidemiologic studies suggest a strong link between poor habitual sleep quality and increased cardiovascular disease risk. However, the underlying mechanisms are not entirely clear. Metabolomic profiling may elucidate systemic differences associated with that influence cardiometabolic health.We explored cross-sectional associations plasma metabolites in nested case-control study of coronary heart (CHD) Women's Health Initiative (WHI; n = 1956) attempted to replicate results an independent...
Background and Objectives: Atherosclerosis is an inflammatory condition that results in cholesterol accumulating within vessel wall cells. Atherosclerotic cardiovascular disease the leading cause of mortality worldwide due to this being a major contributor myocardial infarctions cerebrovascular accidents. Research suggests accumulation occurring precisely arterial endothelial cells triggers atherogenesis exacerbates atherosclerosis. Furthermore, inflamed endothelium acts as catalyst for...
Background People living with HIV have an increased risk of left ventricular diastolic dysfunction (LVDD) and heart failure. HIV-associated LVDD may reflect both cardiomyocyte systemic metabolic derangements, but the underlying pathways remain unclear. Methods Results To explore such pathways, we conducted a pilot study in Bronx Brooklyn sites WIHS (Women's Interagency Study) who participated concurrent, separate, metabolomics echocardiographic ancillary studies. Liquid chromatography tandem...
To evaluate plasma acylcarnitine profiles and their relationships with progression of carotid artery atherosclerosis among individuals without HIV infection.Prospective cohort studies 499 HIV-positive 206 HIV-negative from the Women's Interagency Study Multicenter AIDS Cohort Study.Twenty-four species were measured in samples participants at baseline. Carotid plaque was assessed using repeated B-mode ultrasound imaging 2004-2013. We examined associations individual aggregate short-chain...
Abstract Background: An examination was conducted to understand the prevalence of neutropenia in pts managed with SG real-world setting, as ASCENT trial demonstrated a 63% rate those treated SG1. In addition, an assessment performed see whether who developed on received GCSF and how use impacted pt DOT SG. Methods: This utilized Integra Connect PrecisionQ de-identified database over 2 million cancer across 500 sites care evaluate (< 1500 neutrophils) among were SG, utilization...
Abstract Background: An assessment was performed to understand the degree of post-approval provider adoption two antibody-drug conjugates, fam-trastuzumab deruxtecan-nxki (FTD) and sacituzumab govitecan-hziy (SG), treat breast cancer in community oncology setting. In addition, an evaluation assess pt DOT based on volume pts those therapies treated by each provider. cancer, FTD initially approved U.S. December 20, 2019, SG April 22, 2020. Methods: This used Integra Connect PrecisionQ...
Introduction: Altered acylcarnitine concentrations may reflect impaired mitochondrial metabolism and are implicated in cardiovascular disease (CVD). Disturbances carnitine have been observed HIV infection, but it is unknown whether this related to CVD risk infected people. Methods: Twenty-six species were profiled with ultrahigh-performance liquid chromatography/tandem mass spectrometry 705 men women or at of infection the Multicenter AIDS Cohort Study Women’s Interagency Study. Using a...
Abstract Broad spectrum vaccines could provide a solution to the emergence of antibiotic resistant microbes, pandemics and engineered biothreat agents. Here, we describe modular vaccine (composite infection technology (ciVAX)) which can be rapidly assembled in 4 5 components are already approved for human use. ciVAX consists an injectable biomaterial scaffold with factors recruit activate dendritic cells (DC) vivo microbeads conjugated broad-spectrum opsonin Fc-Mannose-binding Lectin (FcMBL)...
Background: Unbiased “non-targeted” metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, though there have been few successful applications to human disease. We aimed uncover novel biomarkers of non-alcoholic fatty liver disease (NAFLD) cardiometabolic using non-targeted metabolomic in well-phenotyped cohorts. Methods: Non-targeted was performed hydrophilic interaction chromatography on a UHPLC Q-Exactive hybrid orbitrap LC/MS system. searched HMDB,...
Background In 1999 North Carolina initiated STI screening programs in seven county jails as part of the CDC Syphilis Elimination Effort (SEE). All were willing to permit for syphilis but only two also screened HIV. 2007 SEE funding was depleted and 7 jail projects converted HIV under Expanded Testing Initiative (ETI). New added (n=21) several have other STIs. is supported by 10 local health departments 5 non-traditional testing sites which assure treatment STDs make referrals care services....