A5024947373- Ectopic Pregnancy Diagnosis and Management
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Abdominal Trauma and Injuries
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- HIV-related health complications and treatments
- Extracellular vesicles in disease
- Reproductive System and Pregnancy
- Diabetes and associated disorders
- Long-Term Effects of COVID-19
- Animal Virus Infections Studies
- Tryptophan and brain disorders
- Prostate Cancer Treatment and Research
- IL-33, ST2, and ILC Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Gestational Trophoblastic Disease Studies
- Cell Adhesion Molecules Research
The Wistar Institute
2022-2024
Tongji University
2023
Shanghai First Maternity and Infant Hospital
2022
Long COVID, a type of post-acute sequelae SARS-CoV-2 (PASC), has been associated with sustained elevated levels immune activation and inflammation. However, the mechanisms that drive this inflammation remain unknown. Inflammation during acute coronavirus disease 2019 could be exacerbated by microbial translocation (from gut and/or lung) to blood. Whether contributes PASC is We did not observe significant elevation in plasma markers bacterial PASC. we observed higher fungal - measured as...
People living with HIV (PLWH) experience increased vulnerability to premature aging and inflammation-associated comorbidities, even when replication is suppressed by antiretroviral therapy (ART). However, the factors associated this remain uncertain. In general population, alterations in N-glycans on IgGs trigger inflammation precede onset of aging-associated diseases. Here, we investigate IgG cross-sectional longitudinal samples from 1214 women men, without HIV. PLWH exhibit an accelerated...
Cervical cancer (CC) is one of the most common malignant tumors female reproductive system. And immune system disorder in patients results an increasing incidence rate and mortality rate. Pyroptosis system-related programmed cell death pathway that produces systemic inflammation by releasing pro-inflammatory intracellular components. However, diagnostic significance pyroptosis-related genes (PRGs) CC still unclear. Therefore, we identified 52 PRGs from TCGA database screened three...
Highly aggressive, metastatic, neuroendocrine prostate cancer, which typically develops from cancer cells acquiring resistance to androgen deprivation therapy, is associated with limited treatment options and hence poor prognosis. We have previously demonstrated that the αVβ3 integrin over-expressed in cancer. now show LM609, a monoclonal antibody specifically targets human integrin, hinders growth of patient-derived xenografts vivo. Our group has recently identified novel binding partner,...
Abstract Background Differentiating between a normal intrauterine pregnancy (IUP) and abnormal conditions including early loss (EPL) or ectopic (EP) is major clinical challenge in pregnancy. Currently, serial β-human chorionic gonadotropin (β-hCG) progesterone are the most commonly used plasma biomarkers for evaluating prognosis when ultrasound inconclusive. However, neither biomarker can predict an EP with sufficient reproducible accuracy. Hence, identification of new that accurately...
Abstract Our group has previously shown that prostate cancer (PrCa)-derived small extracellular vesicles (sEVs) are powerful cell communication mediators as they carry an array of proteins have the ability to change recipient functions. Here, we describe a novel pathway cell-monocyte mediated by sEVs. Since sEVs cargoes alter phenotypes, analyzed via proteomic analysis released from PC3 PrCa cells. Using CRISPR Cas9 methods, downregulated IFIT3 (Interferon-induced with tetratricopeptide...
ABSTRACT Long COVID, a type of Post-Acute Sequelae SARS CoV-2 infection (PASC), has been associated with sustained elevated levels immune activation and inflammation. However, the pathophysiological mechanisms that drive this inflammation remain unknown. Inflammation during acute Coronavirus Disease 2019 (COVID-19) could be exacerbated by microbial translocation (from gut and/or lung) to blood. Whether contributes PASC is We found higher fungal – measured as β-glucan, cell wall...
People with HIV (PWH) experience an increased vulnerability to premature aging and inflammation-associated comorbidities, even when replication is suppressed by antiretroviral therapy (ART). However, the factors that contribute or are associated this remain uncertain. In general population, alterations in glycomes of circulating IgGs trigger inflammation precede onset aging-associated diseases. Here, we investigate IgG cross-sectional longitudinal samples from 1,216 women men, both living...
ABSTRACT Two serologically distinct replication-defective chimpanzee-origin adenovirus (Ad) vectors (AdC) called AdC6 and AdC7 expressing the spike (S) or nucleocapsid (N) proteins of an early SARS-CoV-2 isolate were tested individually as a mixture in hamster COVID-19 challenge model. The N protein, which was expressed fusion protein within herpes simplex virus glycoprotein D (gD) stimulated antibodies CD8 + T cells. S AdC (AdC-S) induced including those with neutralizing activity that part...