A5026110721- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- HIV/AIDS drug development and treatment
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Atherosclerosis and Cardiovascular Diseases
- Adolescent Sexual and Reproductive Health
- Cerebrovascular and Carotid Artery Diseases
- Hepatitis C virus research
- Viral-associated cancers and disorders
- HIV, Drug Use, Sexual Risk
- Reproductive tract infections research
- Hormonal and reproductive studies
- Ovarian function and disorders
- Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Blood Pressure and Hypertension Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Sex work and related issues
- Phytoestrogen effects and research
- Cervical Cancer and HPV Research
University of Southern California
2016-2025
Southern California University for Professional Studies
2005-2022
Stanford University
2021
Keck Hospital of USC
2006-2019
Albert Einstein College of Medicine
2013-2017
Georgetown University Medical Center
2014-2017
SUNY Downstate Health Sciences University
2014-2017
Johns Hopkins University
2014-2017
Georgetown University
2014-2017
University of California, Davis
2017
Background. Individuals infected with human immunodeficiency virus (HIV) have increased risk of cardiovascular events. It is unknown whether T cell activation and senescence, 2 immunologic sequelae HIV infection, are associated vascular disease among HIV-infected adults. Methods. phenotyping carotid ultrasound were assessed 115 women 43 age- race/ethnicity-matched HIV-uninfected controls participating in the Women's Interagency Study. Multivariate analyses used to assess association...
To compare outcomes of patients with HIV-Burkitt's lymphoma (HIV-BL) and HIV-diffuse large-cell (HIV-DLCL) after treatment CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) or M-BACOD (methotrexate, bleomycin, cyclophosphamide, etoposide) in pre-highly active antiretroviral therapy (HAART) versus HAART eras.Three hundred sixty-three AIDS-related diagnosed from 1982 to 2003 were reviewed retrospectively, including 262 the pre-HAART (HIV-BL, 117; HIV-DLCL, 145) 101 era 18; 83)....
Background: CD4 + T cells play an important role in atherosclerosis, but their antigen specificity is poorly understood. Immunization with apolipoprotein B (ApoB, core protein of low density lipoprotein) known to be atheroprotective animal models. Here, we report on a human APOB peptide, p18, that sequence-identical mouse ApoB and binds both major histocompatibility complex class II molecules. Methods: We constructed p18 tetramers detect APOB-specific assayed phenotype by flow cytometry...
Millions of women in the United States and across globe abruptly discontinued postmenopausal hormone therapy (HT) after initial Women's Health Initiative trial publication. Few data describing effects HT cessation on hip fracture incidence general population are available. We evaluated impact a large cohort from Southern California Kaiser Permanente health management organization.In this longitudinal observational study, 80,955 using as July 2002 were followed up through December 2008. Data...
Reproductive factors are associated with reduced risk of breast cancer, but less is known about whether there differential protection against subtypes cancer. Assuming reproductive act through hormonal mechanisms they should protect predominantly cancers expressing oestrogen (ER) and progesterone (PR) receptors. We examined the effect on subgroups tumours defined by hormone receptor status as well histology using data from NIHCD Women's Contraceptive Experiences (CARE) Study, a multicenter...
Purpose To compare the prognostic factors for survival and validity of International Prognostic Index (IPI) in patients with HIV-related diffuse large-cell lymphoma (HIV-DLCL) treated curative intent pre–highly active antiretroviral therapy (HAART) era versus HAART era. Patients Methods We retrospectively reviewed 192 HIV-DLCL diagnosed from 1982 to 2003. Pre-HAART included 120 who did not receive HAART, whereas 72 after January 1997 received HAART. Results There were no statistically...
Postmenopausal hormone therapy has been examined extensively in relation to cardiovascular disease. However, research relating serum levels of sex hormones disease is sparse, and the results are inconclusive.We measured longitudinally collected samples 180 postmenopausal women, 91 randomized 17beta-estradiol 89 placebo, Estrogen Prevention Atherosclerosis Trial. Repeated measures were tested for an association with carotid artery intima-media thickness (CIMT), which was also assessed over 2...
Infection with hepatitis C virus (HCV) or human immunodeficiency (HIV) may be associated atherosclerosis and vascular disease. Macrophages are a major component of atherosclerotic plaque, classically activated (M1) macrophages contribute to plaque instability. Our goal was identify plasma biomarkers that reflect macrophage inflammation subclinical atherosclerosis. We tested whether M1 produce galectin-3-binding protein in vitro. Then, we measured the soluble cluster differentiation (CD) 163...
Objectives To investigate the association between reproductive history indicators of hormonal exposure, including period, pregnancy, and use contraceptives, mid‐ late‐life cognition in postmenopausal women. Design Analysis baseline data from two randomized clinical trials: Women's Isoflavone Soy Health Early vs Late Intervention Trial Estradiol. Setting University academic research center. Participants Naturally menopausal women (N = 830). Measurements were uniformly evaluated using a...
Anemia is common in HIV-infected individuals and may be associated with decreased survival.To ascertain the impact of highly active antiretroviral therapy (HAART) on anemia relationship between overall survival women.A prospective multicenter study HIV-1 infection women. Visits occurred every 6 months, including a standardized history, physical examination, comprehensive laboratory evaluation. The setting was university-affiliated clinic at sites United States. Participants were 2056 women...
<h3>Background:</h3> Neutropenia is well described in individuals infected with human immunodeficiency virus (HIV) and occurs approximately 10% to 50% of cases. Neither the effect highly active antiretroviral therapy (HAART) on neutrophil counts nor significance neutropenia terms survival has previously been evaluated. <h3>Methods:</h3> The prevalence among 1729 HIV-infected women, followed up as part Women's Interagency HIV Study, was CD4 lymphocyte counts, HIV-1 RNA levels, complete blood...
Background Effective interventions to improve and maintain strength (force-generating capacity) endurance are needed for children with cerebral palsy (CP). Objective This study was performed examine the effects of a stationary cycling intervention on muscle strength, locomotor endurance, preferred walking speed, gross motor function in spastic diplegic CP. Design phase I randomized controlled trial single blinding. Setting The were community-based outpatient physical therapy clinics. Outcome...
Maternal perinatal depression (PND) may interfere with effective HIV care. In order to begin examining the prevalence and characteristics of PND in HIV-infected women, we analyzed data from medical records all women who had received care Maternal-Child Adolescent Center for Infectious Diseases Virology at LAC/USC Medical 1997 through 2006. Data 273 individual (328 live births) were analyzed. Demographic, history, psychosocial, pregnancy-related, HIV-related factors measured during period...
Background: Data regarding the association between HIV and diabetes mellitus (DM) are conflicting, with little known impact of including hemoglobin A1C (A1C) as a criterion for DM. Methods: Pooled logistic regression was used to quantify DM in 1501 HIV-infected 550 HIV-uninfected participants from Women's Interagency Study. Incident defined using following 3 criteria, definition I: fasting glucose (FG) ≥126 mg/dL, anti-DM medication or reporting diagnosis (with confirmation by FG mg/dL...
Background. Because activation of T cells is associated with human immunodeficiency virus (HIV) pathogenesis, CD4 and CD8 levels in patients coinfected HIV hepatitis C (HCV) may explain conflicting reports regarding effects HCV on disease progression. Methods. Kaplan-Meier multivariate Cox regression models were used to study the risk incident clinical AIDS AIDS-related deaths among 813 HCV-negative women infection, 87 HCV-positive nonviremic coinfection, 407 viremic coinfection (median...
Significance Hormone variations after menopause may influence brain processes concerned with cognition and mood. Effects differ for exposures near compared much later. We addressed this prediction using serum concentrations of endogenous estradiol, estrone, progesterone, testosterone in 643 healthy women not hormone therapy (early group, <6 y menopause; late 10+ y). In combined analyses, levels were unrelated to verbal memory, executive functions, global cognition, or For estradiol (our...
Objectives: Prevalence of microalbuminuria is increased in patients with HIV. Microalbuminuria associated mortality other populations, including diabetics, for whom testing standard care. We investigated whether HIV-infected women not receiving antiretroviral therapy. Methods: Urinalysis proteinuria and semiquantitative were performed specimens from 2 consecutive visits 1547 enrolled the Women's Interagency HIV Study 1994-1995. Time to death was modeled using proportional hazards analysis....
Despite the success of antiretroviral therapy (ART), people living with HIV (PLWH) are still at higher risk for cardiovascular diseases (CVDs) that mediated by chronic inflammation. Identification novel inflammatory mediators inherent potential to be used as CVD biomarkers and also therapeutic targets is critically needed better stratification disease management in PLWH. Here, we investigated expression role multi-isoform proinflammatory cytokine IL-32 subclinical atherosclerosis PLWH (n=49...
Sex hormones, adipokines, and ghrelin have been implicated in central control of appetite, energy homeostasis, maintenance fat mass, inflammation. Women tend to gain weight after menopause adipose tissue is a major source sex steroid postmenopause. Understanding the dynamics these analytes are particular importance postmenopausal women, who at greater risk for cardiometabolic diseases. This study sought evaluate associations adipokines with hormone concentrations women. We conducted...
The aging HIV population has increased comorbidity burden and consequently non-antiretroviral medication utilization. Many medications have known neurocognitive-adverse effects ("NC-AE medications"). We assessed the cognitive of NC-AE in HIV+ HIV- women.
To determine the impact of highly active antiretroviral therapy (HAART) on salivary gland function in human immunodeficiency virus (HIV) positive women from Women's Interagency HIV Study (WIHS).Longitudinal cohort study.A total 668 WIHS with an initial and at least one follow-up oral sub-study visit contributed 5358 visits. Salivary was assessed based a dry mouth questionnaire, whole unstimulated stimulated flow rates, enlargement or tenderness lack saliva palpation major glands.Changes...