A5063657135- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Child and Adolescent Health
- Preterm Birth and Chorioamnionitis
- Infant Nutrition and Health
- Advanced Neuroimaging Techniques and Applications
- Congenital Heart Disease Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Cerebral Palsy and Movement Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Infant Health and Development
- Pregnancy and preeclampsia studies
- Retinopathy of Prematurity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Children's Physical and Motor Development
- Fetal and Pediatric Neurological Disorders
- Prenatal Screening and Diagnostics
- Family and Disability Support Research
- Global Maternal and Child Health
The University of Melbourne
2016-2025
Royal Women's Hospital
2016-2025
Murdoch Children's Research Institute
2016-2025
Royal Children's Hospital
2012-2024
Royal Ottawa Mental Health Centre
2000-2024
Infant
1995-2023
Hyundai Mobis (South Korea)
2023
Infant Foundation
2023
Washington University in St. Louis
2006-2021
Allen Institute for Brain Science
2021
Bronchopulmonary dysplasia is associated with ventilation and oxygen treatment. This randomized trial investigated whether nasal continuous positive airway pressure (CPAP), rather than intubation ventilation, shortly after birth would reduce the rate of death or bronchopulmonary in very preterm infants.We randomly assigned 610 infants who were born at 25-to-28-weeks' gestation to CPAP 5 minutes birth. We assessed outcomes 28 days age, 36 weeks' gestational before discharge.At 33.9% 307...
Methylxanthines reduce the frequency of apnea prematurity and need for mechanical ventilation during first seven days therapy. It is uncertain whether methylxanthines have other short- long-term benefits or risks in infants with very low birth weight.We randomly assigned 2006 weights 500 to 1250 g 10 life receive either caffeine placebo, until drug therapy was no longer needed. We evaluated short-term outcomes before discharge home.Of 963 who were remained alive at a postmenstrual age 36...
Methylxanthine therapy is commonly used for apnea of prematurity but in the absence adequate data on its efficacy and safety. It uncertain whether methylxanthines have long-term effects neurodevelopment growth.We randomly assigned 2006 infants with birth weights 500 to 1250 g receive either caffeine or placebo until was no longer needed. The primary outcome a composite death, cerebral palsy, cognitive delay (defined as Mental Development Index score <85 Bayley Scales Infant Development),...
To determine the effectiveness and safety of moderate whole-body hypothermia in newborns with hypoxic-ischemic encephalopathy born hospitals without newborn intensive care facilities or complicated equipment.Multicenter, international, randomized controlled trial.Neonatal units Australia, New Zealand, Canada, United States (N = 28) from February 2001 through July 2007.Newborns 35 weeks' gestation more, indicators peripartum hypoxia-ischemia to severe clinical encephalopathy, randomly...
The clinically appropriate range for oxygen saturation in preterm infants is unknown. Previous studies have shown that had reduced rates of retinopathy prematurity when lower targets were used.
Objective. To determine the frequency, nature, and severity of executive dysfunction (EDF) at 8 years age in extremely low birth weight (ELBW)/very preterm infants who were born 1990s, compared with normal (NBW) control subjects. Methods. A geographically determined cohort study was conducted Victoria, Australia. The ELBW/very comprised 298 consecutive survivors 2 had gestational ages &lt;28 completed weeks or weights &lt;1000 g during 1991-1992. NBW 262 randomly selected children...
Very preterm infants are prone to apnea and have an increased risk of death or disability. Caffeine therapy for prematurity reduces the rates cerebral palsy cognitive delay at 18 months age.To determine whether neonatal caffeine has lasting benefits newly apparent risks early school age.Five-year follow-up from 2005 2011 in 31 35 academic hospitals Canada, Australia, Europe, Israel, where 1932 2006 participants (96.3%) had been enrolled randomized, placebo-controlled Apnea Prematurity trial...
OBJECTIVES. The purpose of this work was to determine the relationship between lung function in late adolescence and bronchopulmonary dysplasia, establish whether changed more from earlier childhood those with assess effect different definitions dysplasia on respiratory outcome. METHODS. Subjects were composed 147 survivors birth weight &lt;1500 g Royal Women's Hospital (Melbourne, Australia) born during 1977–1982 who had tests at a mean age 18.9 years. Of subjects, 33 (22%) newborn...
Uncertainty exists about the benefit of dietary docosahexaenoic acid (DHA) on neurodevelopment preterm infants.To determine effect meeting estimated DHA requirement infants at 18 months' corrected age.Randomized, double-blind controlled trial enrolling born less than 33 weeks' gestation from April 2001 to October 2005 5 Australian tertiary hospitals, with follow-up months.High-DHA (approximately 1% total fatty acids) enteral feeds compared standard 0.3% day 2 4 life until term age.Bayley...
To define the nature and frequency of brain injury growth impairment in very preterm (VPT) infants by using MRI at term-equivalent age to relate these findings perinatal risk factors 2-year neurodevelopmental outcomes.MRI scans from 3 VPT cohorts (n = 325) were reviewed. The severity injury, including periventricular leukomalacia intraventricular cerebellar hemorrhage, was graded. Brain assessed measures biparietal width (BPW) interhemispheric distance. Neurodevelopmental outcome 2 years...
Infants born preterm are at increased risk of adverse health and developmental outcomes. Mortality morbidity after birth impose a burden on finite public sector resources. This study considers the economic consequences from to adult life compares costs accruing those with term.A decision-analytic model was constructed estimate over first 18 years birth, stratified by week gestational age birth. Costs were discounted reported in UK pounds 2006 prices. Probabilistic sensitivity analysis used...
The use of high-flow nasal cannulae is an increasingly popular alternative to continuous positive airway pressure (CPAP) for noninvasive respiratory support very preterm infants (gestational age, <32 weeks) after extubation. However, data on the efficacy or safety such in this population are lacking.In multicenter, randomized, noninferiority trial, we assigned 303 receive treatment with either (5 6 liters per minute) CPAP (7 cm water) primary outcome was failure within 7 days. Noninferiority...
OBJECTIVE: Research is required to monitor changes in the nature of neurobehavioral deficits extremely preterm (EP) or low birth weight (ELBW) survivors. This study examines cognitive, academic, and behavioral outcomes at age 8 years for a regional cohort EP/ELBW children born 1997. METHODS: The comprised all live births with gestational &lt;28 weeks &lt;1000 g state Victoria, Australia, Of 317 births, 201 (63.4%) survived 2 age. A term/normal (T/NBW) was recruited comprising 199...
Moderate and late preterm (MLPT) births comprise most infants. Therefore, long-term developmental concerns in this population potentially have a large public health influence. While there are increasing reports of problems MLPT children, detail is lacking on the precise domains that affected.To compare neurodevelopment social-emotional development between infants term-born control at age 2 years.This investigation was prospective longitudinal cohort study single tertiary hospital....