A5016911778- Acne and Rosacea Treatments and Effects
- melanin and skin pigmentation
- Contact Dermatitis and Allergies
- Skin Protection and Aging
- Dermatology and Skin Diseases
- Genetic and rare skin diseases.
- Neonatal skin health care
- Dermatological diseases and infestations
- Tumors and Oncological Cases
- Pharmacological Effects of Natural Compounds
- Hair Growth and Disorders
- Parvovirus B19 Infection Studies
- Medicine and Dermatology Studies History
- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- Dermatologic Treatments and Research
- Hematopoietic Stem Cell Transplantation
- Allergic Rhinitis and Sensitization
- Vascular Malformations and Hemangiomas
- Skin Diseases and Diabetes
- Diversity and Career in Medicine
- Eosinophilic Disorders and Syndromes
- Urticaria and Related Conditions
- Congenital Ear and Nasal Anomalies
- Medicine, History, and Philosophy
University of California, Los Angeles
2017-2024
Rady Children's Hospital-San Diego
2016
Massachusetts General Hospital
2010-2015
Harvard University
2010-2015
Brigham and Women's Hospital
2015
Boston Children's Hospital
2014
University of Massachusetts Chan Medical School
2013
Boston University
2010
Acne affects 1 in 10 people globally, often resulting disfigurement. The disease involves excess production of lipids, particularly squalene, increased growth Cutibacterium acnes, and a host inflammatory response with foamy macrophages. By combining single-cell spatial RNA sequencing as well ultrahigh-resolution Seq-Scope analyses early acne lesions on back skin, we identified TREM2 macrophages expressing lipid metabolism proinflammatory gene programs proximity to hair follicle epithelium...
Abstract Background Acne vulgaris is a common skin disease with large quality of life impact, characterized by comedones, inflammatory lesions, secondary dyspigmentation and scarring. There are few objective studies comparing acne epidemiology between racial ethnic groups. Objective This study aimed to define the prevalence subtypes in women different groups from four ethnicities. Methods The sample consisted 2895 (384 African American, 520 Asian, 1295 Caucasian, 258 Hispanic 438 Continental...
In dermatology, the development of objective, standardized quality measures that can be used in a clinical setting is important to able respond needs payers and credentialing licensure bodies demonstrate dermatologic value.OBJECTIVE To examine feasibility using Physician Global Assessment (PGA) scores collect track patient acne psoriasis outcomes over time. DESIGN, SETTING, AND PARTICIPANTSThe PGA severity were included on physicians' billing sheets for patients with seen at tertiary care...
Introduction: Acne treatment options vary widely, with many patients using dietary supplements. Despite their popularity, these products pose safety concerns due to lack of FDA approval for or efficacy before release. The US Institute Medicine sets Tolerable Upper Intake Levels (ULs) nutrients, but there are no regulatory limits prevent supplements from exceeding ULs. Methods: On March 3, 2024, active ingredients the top 50 best-selling acne were collected Amazon. Data analyzed identify and...
Abstract Background Pediatric leukemia cutis ( LC ) is often difficult to diagnose due similarity in appearance other dermatologic diseases. Several case reports and smaller series have been published the medical literature, but studies on larger cohorts of children with are lacking. Objective This study aimed better characterize clinical features, course, prognosis pediatric population. Methods We performed a retrospective 31 patients diagnosed at Boston Children's Hospital Philadelphia....
A comprehensive understanding of the intricate cellular and molecular changes governing complex interactions between cells within acne lesions is currently lacking. Herein, we analyzed early papules from six subjects with active vulgaris, utilizing single-cell high-resolution spatial RNA sequencing. We observed significant in signaling pathways across seven different cell types when comparing lesional skin samples (LSS) to healthy (HSS). Using CellChat, constructed an atlas for HSS,...
Abstract A number of lesions have been documented to arise within congenital melanocytic nevi ( CMNs ). Although the most frequent malignancy arising a CMN is melanoma, association between rhabdomyosarcoma and has rarely documented. We present case in 4‐month‐old girl with giant CMN. She presented for evaluation pedunculated lesion at superior gluteal crease that had since birth exhibited rapid growth. Biopsy revealed two distinct components: an expansile proliferation pleomorphic cells...
To the Editor: Prurigo pigmentosa (PP) is an inflammatory skin disease characterized by a sudden eruption of pruritic, erythematous papules in reticular pattern followed hyperpigmentation.1Nagashima M. pigmentosa--clinical observations our 14 cases.J Dermatol. 1978; 5: 61-67https://doi.org/10.1111/j.1346-8138.1978.tb01049.xCrossref PubMed Scopus (95) Google Scholar In recent years, PP has been anecdotally associated with ketogenic diet.2Delaleu J. Grynberg-Laloum E. Moguelet P. et al.Prurigo...
Abstract Orf is a zoonotic parapoxvirus typically transmitted to humans by bite from goats or sheep. We present an unusual case of multiple orf lesions on the fingers 13‐month‐old child who was bitten goat and subsequently developed progressive swelling, blistering, necrotic papulonodules hand followed additional diffuse, pruritic, papular rash. A primary diagnosis infection confirmed using real‐time polymerase chain reaction, diffuse eruption clinically consistent with id reaction....
Many baby cleansers are promoted as hypoallergic products; however, these claims not typically validated. This study assessed the 50 best-selling from online retailer Amazon for potential allergens. We found that presence of most marketing claims, including "hypoallergenic" or "allergy-tested," did correlate with number allergens in a cleanser. Furthermore, total cleanser was positively correlated allergens, highlighting discordance between and allergen content cleansers.
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Current models of Goltz syndrome cannot estimate the overall neocollagenesis and marked shift in collagen types after ablative fractional laser resurfacing (AFR) within treated areas focal dermal hypoplasia (FDH).To clinically improve FDH by using AFR to characterize specific ratio associated with observed clinical changes.This case report a girl used extensive laboratory evaluation multiple observers blinded patient's status. Serial samples unaffected skin constituted internal control...
Abstract Condylomata acuminata ( CA ), or anogenital warts, are typically benign lesions caused by human papillomavirus infection. Although they rare, immunocompromised individuals at a higher risk of undergoing transformation into invasive anal squamous cell carcinoma SCC ). These patients need aggressive evaluation and management. Treatment is challenging, particularly for hosts, in whom warts resistant to treatment commonly recur. Currently, there no gold standard , especially children...
Severe mosquito bite allergy (SMBA) is characterized by necrotic skin lesions and systemic symptoms. Chronic active Epstein-Barr virus (EBV) infection, when superimposed with SMBA, a key driver for catastrophic clinical consequences, such as uncontrolled lymphoproliferation. This interplay of significance due to its association hemophagocytic lymphohistiocytosis (HLH) and/or EBV-driven malignancies. Here, we report case SMBA that developed in 14-year-old Hispanic boy led fatal secondary HLH.