A5052588794- Neurogenesis and neuroplasticity mechanisms
- Single-cell and spatial transcriptomics
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
Barcelona Biomedical Research Park
2023-2024
Universitat Pompeu Fabra
2022-2024
Hospital del Mar Research Institute
2022
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that centrally involved in cognition. We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC. Although most cell subtypes defined transcriptomically are conserved, we detected several exist only a subset species as well substantial species-specific molecular differences across homologous neuronal, glial, non-neural subtypes. latter...
During early telencephalic development, intricate processes of regional patterning and neural stem cell (NSC) fate specification take place. However, our understanding these in primates, including both conserved species-specific features, remains limited. Here, we profiled 761,529 single-cell transcriptomes from multiple regions the prenatal macaque telencephalon. We deciphered molecular programs organizing centers their cross-talk with NSCs, revealing primate-biased galanin-like peptide (...
Abstract Vast quantities of multi-omic data have been produced to characterize the development and diversity cell types in cerebral cortex humans other mammals. To more fully harness collective discovery potential these data, we assembled gene-level transcriptomic from 188 published studies neocortical development, including transcriptomes ∼30 million single-cells, extensive spatial experiments RNA sequencing sorted cells bulk tissues: nemoanalytics.org/landing/neocortex . Applying joint...
ABSTRACT The implications of the early phases human telencephalic development, involving neural stem cells (NSCs), in etiology cortical disorders remain elusive. Here, we explored expression dynamics and neuropsychiatric disorder-associated genes datasets generated from NSCs across fate transitions vitro vivo. We identified risk expressed brain organizers sequential gene regulatory networks corticogenesis revealing disease-specific critical phases, when are more vulnerable to dysfunctions,...
Abstract Early telencephalic development involves patterning of the distinct regions and fate specification neural stem cells (NSCs). These processes, mainly characterized in rodents, remain elusive primates thus our understanding conserved species-specific features. Here, we profiled 761,529 single-cell transcriptomes from multiple prenatal macaque telencephalon. We defined molecular programs early organizing centers their cross-talk with NSCs, finding primate-biased signaling active...