A5073108657- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Neurobiology and Insect Physiology Research
- Memory and Neural Mechanisms
- Primate Behavior and Ecology
- Neuropeptides and Animal Physiology
- Zebrafish Biomedical Research Applications
- Olfactory and Sensory Function Studies
- Ion channel regulation and function
- Functional Brain Connectivity Studies
- Nerve injury and regeneration
- Advanced Neuroimaging Techniques and Applications
- Neuroendocrine regulation and behavior
- Neural and Behavioral Psychology Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurotransmitter Receptor Influence on Behavior
- Developmental Biology and Gene Regulation
- Veterinary Medicine and Surgery
- Color Science and Applications
- Epilepsy research and treatment
National Institute of Mental Health
2024-2025
National Institutes of Health
2025
Monash University
2014-2024
Australian Regenerative Medicine Institute
2014-2024
NeuroDevelopment Center
2024
University of Baltimore
2022
Swansea University
2022
Danville Community College
2022
University of California, Davis
2020
EMBL Australia
2017-2019
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that centrally involved in cognition. We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC. Although most cell subtypes defined transcriptomically are conserved, we detected several exist only a subset species as well substantial species-specific molecular differences across homologous neuronal, glial, non-neural subtypes. latter...
It has been suggested that the development of cerebral cortex reflects its hierarchical organization, with primary sensory areas being first to reach structural and functional maturity, higher-order association last. In present study, we labelled New World marmoset monkeys late fetal early postnatal ages an antibody non-phosphorylated neurofilament, a marker maturation subset pyramidal cells. Supporting concept maturation, found at birth cells were in visual, auditory somatosensory areas,...
Previous studies of macaque and human cortices identified cytoarchitectonically distinct germinal zones; the ventricular zone inner subventricular (ISVZ), outer (OSVZ). To date, OSVZ has only been described in gyrencephalic brains, separated from ISVZ by an fiber layer considered a milestone that triggered increased neocortical neurogenesis. However, this observation assessed handful species without identification different progenitor populations. We examined Amazonian rodent agouti...
The hierarchical development of the primate visual cortex and associated streams remains somewhat a mystery. While anatomical, physiological, psychological studies have demonstrated early maturation dorsal “where”/“how” or motion cortical stream, little is known about circuitry responsible. influence retinogeniculostriate pathway has been investigated, but attention paid to role two more recently described disynaptic retinothalamic projections middle temporal (MT) area, an maturing stream...
The dorsomedial area (DM), a subdivision of extrastriate cortex characterized by heavy myelination and relative emphasis on peripheral vision, remains the least understood main targets striate (V1) projections in primates. Here we placed retrograde tracer injections encompassing full extent this marmoset monkeys, performed quantitative analyses numerical strengths laminar patterns its afferent connections. We found that feedforward from V1 second visual (V2) account for over half inputs to...
People with Down syndrome (DS) exhibit abnormal brain structure. Alterations affecting neurotransmission and signalling pathways that govern function are also evident. A large number of genes simultaneously expressed at levels in DS; therefore, it is a challenge to determine which gene(s) contribute specific abnormalities, then identify the key molecular involved. We generated RCAN1-TG mice study consequences RCAN1 over-expression investigate contribution phenotype DS. structural...
Human amnion epithelial cells (hAECs) are nonimmunogenic, nontumorigenic, anti-inflammatory normally discarded with placental tissue. We reasoned that their profile of biological features, wide availability, and the lack ethical barriers to use could make these useful as a therapy in ischemic stroke.We tested efficacy acute (1.5 hours) or delayed (1-3 days) poststroke intravenous injection hAECs 4 established animal models cerebral ischemia. Animals included young (7-14 weeks) aged mice...
Cauda equina syndrome (CES) results from nerve root compression in the lumbosacral spine, usually due to a prolapsed intervertebral disc. Evidence for management of CES is limited by its infrequent occurrence and lack standardised clinical definitions outcome measures. This prospective multi-centre observational cohort study adults with UK. We assessed presentation, investigation, management, all Core Outcome Set domains up one year post-operatively using clinician participant reporting....
Human Toll-like receptors (TLRs) TLR7, TLR8, and TLR9 are important immune sensors of foreign nucleic acids encountered by phagocytes. Although there is growing evidence implicating TLR7 in the detection intracellular pathogenic bacteria, characterization such a role for TLR8 currently lacking. A recent genetic study has correlated presence single nucleotide polymorphism (SNP) (rs3764880:A>G; p.Met1Val) with development active tuberculosis, suggesting phagosomal bacteria. Here we provide...
Significance Visually guided actions have been central to the neural and behavioral evolution of primates, culminating in precision grasping object manipulation. Here, we reveal that establishment maturation cortical areas controlling reach-and-grasp behaviors are dependent on a transient visual pathway from retina medial inferior pulvinar thalamus, which relays information dorsal stream cortex, via middle temporal (MT) area, early life. Disruption this life leads permanent anatomical,...
We tested current hypotheses on the functional organization of third visual complex, a particularly controversial region primate extrastriate cortex. In anatomical experiments, injections retrograde tracers were placed in dorsal cortex immediately rostral to second area (V2) New World monkeys (Callithrix jacchus), revealing topography interconnections between "third tier" and primary (V1). The data indicate presence dorsomedial (DM), which represents entire upper lower quadrants field,...
Abstract Information about the responses of neurons to spatial and temporal frequencies visual stimuli is important for understanding types computations being performed in different areas. We characterized spatiotemporal selectivity middle area (MT), which deemed central processing direction speed motion. Recordings obtained marmoset monkeys using high‐contrast sine‐wave gratings as revealed that majority had bandpass frequency tuning, these parameters was largely separable. Only one‐third...
The middle temporal area (MT/V5) is an anatomically distinct region of primate visual cortex that specialized for the processing image motion. It generally thought some neurons in MT are capable signalling motion complex patterns, but this has only been established macaque monkey. We made extracellular recordings from single units anaesthetized marmosets, a New World show through quantitative analyses (35 185; 19%) pattern ('pattern cells'). Across several dimensions, response cells...
Abstract The primate visual brain possesses a myriad of pathways, whereby information originating at the retina is transmitted to multiple subcortical areas in parallel, before being relayed onto cortex. dominant retinogeniculostriate pathway has been an area extensive study, and Vivien Casagrande's work examining once overlooked koniocellular lateral geniculate nucleus generated interest how alternate pathways can contribute perception. Another relay center inferior pulvinar (PI), which...