A5101686802- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Reproductive System and Pregnancy
- Adrenal Hormones and Disorders
- Tracheal and airway disorders
- Immune Cell Function and Interaction
- Congenital Heart Disease Studies
- Congenital heart defects research
- Virus-based gene therapy research
- Mycobacterium research and diagnosis
- Ferroptosis and cancer prognosis
- interferon and immune responses
- Spinal Cord Injury Research
- BRCA gene mutations in cancer
- Proteoglycans and glycosaminoglycans research
- PI3K/AKT/mTOR signaling in cancer
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Pregnancy and preeclampsia studies
- Hormonal Regulation and Hypertension
First Affiliated Hospital of Jinan University
2024
South China University of Technology
2020-2024
Guangzhou Medical University
2008-2024
Guangzhou First People's Hospital
2008-2024
Shanghai Tenth People's Hospital
2023
Tongji University
2023
University of Hong Kong - Shenzhen Hospital
2021-2022
University of Science and Technology of China
2022
University of Hong Kong
2021-2022
Abstract Background Papillary thyroid carcinoma (PTC) is the most common malignant endocrine tumour, and its incidence prevalence are increasing considerably. Cellular heterogeneity in tumour microenvironment important for PTC prognosis. Spatial transcriptomics a powerful technique cellular study. Methods In conjunction with clinical pathologist identification method, spatial was employed to characterise location RNA profiles of PTC‐associated cells within tissue sections. The RNA‐clinical...
Colorectal cancer (CRC) remains one of the most common cancers worldwide. Increasing evidence indicates that SPRY4 intronic transcript 1 (SPRY4-IT1) regulate cell growth, differentiation, apoptosis, and progression. However, expression function SPRY4-IT1 in progression CRC largely unknown. Here, we reported was upregulated CRC. Increased associated with larger tumor size higher clinical stage. In vitro experiments revealed knockdown significantly inhibited proliferation by causing G1 arrest...
Dysregulated maternal fatty acid metabolism increases the risk of congenital heart disease (CHD) in offspring with an unknown mechanism, and effect folic fortification preventing CHD is controversial. Using gas chromatography coupled to either a flame ionization detector or mass spectrometer (GC-FID/MS) analysis, we find that palmitic (PA) concentration significantly serum samples pregnant women bearing children CHD. Feeding mice PA increased cannot be rescued by supplementation. We further...
The activation of Treg cell subsets is critical for the prognosis tumor patients; however, their heterogeneity and disease association in papillary thyroid carcinoma (PTC) need further investigation. We performed high-dimensional flow cytometry immunophenotyping on tissues matched peripheral blood samples from patients with multinodular goiters or PTC. analyzed CD4 + T phenotypes compared recurrence-free survival PTC different subset characteristics using TCGA. Furthermore, recurrent...
The disruption of the blood spinal cord barrier (BSCB) after injury (SCI) can trigger secondary tissue damage. Edaravone is likely to protect BSCB as a free radical scavenger, whereas it has been rarely reported thus far. In this study, protective effect edaravone was investigated with use compression injured rats and human brain microvascular endothelial cells (HBMECs) injury. As indicated by result treatment facilitated functional recovery were subjected SCI, ameliorated vascular damage,...
Thyroid cancer is the most common endocrine carcinoma, with papillary thyroid carcinoma (PTC) accounting for 80%‐90% of cancers. Accumulating studies reported that mitochondria plays an important role in regulation cell proliferation. ALDH5A1, may function as oncogene or tumour suppressor various human cancers, and ALDH5A1 PTC still unclear. The aim this study was to investigate clinical significance expression its functions PTC. In present study, we studied on primary Cancer Genome Atlas...
Objective: Anaplastic thyroid cancer/ATC is a highly aggressive malignancy with extremely poor prognosis.Resveratrol/Res promotes re-differentiation of cancer cells and exerts inhibitory effects on ATC cells.Sodium/iodide symporter/NIS phosphate tension homology deleted chromsome ten/PTEN levels are positively correlated the grade differentiation, while impact Res them remain unknown. Materials Methods:The patterns NIS PTEN expression intracellular distribution in THJ-16T THJ-21T Nthy-ori...
The placenta is important for fetal development in mammals, and spatial transcriptomic profiling of helps to resolve its structure function. In this study, we described the landscape transcriptome human placental villi obtained from two pregnant women at first trimester using modified Stereo-seq method applied paraformaldehyde (PFA) fixation samples. PFA was better than fresh embedded optimum cutting temperature (OCT) compound, since it greatly improved tissue morphology specificity RNA...
High recurrence of colon cancer liver metastasis is observed in patients after hepatic surgery, and the cause believed to be mostly due growth residual microscopic metastatic lesions within liver. Therefore, triggering progression occult foci may a novel strategy for improving survival from metastases. In present study, we identified an anti-recurrence effect ulinastatin on mice hepatectomy. Transwell cell invasion assays demonstrated that significantly inhibited vitro invasive ability...
Pulmonary arterial hypertension describes a group of diseases characterised by raised pulmonary vascular resistance, resulting from remodelling in the pre-capillary resistance arterioles. Left untreated, patients die right heart failure. involves all cell types but to date precise roles different cells is unknown. This study investigated differences basal gene expression between and controls using both human microvascular endothelial artery smooth muscle cells. Human were cultured...
Abstract Context Adult cancer survivors are at a heightened risk for secondary primary differentiated thyroid carcinoma (2-DTC). The characteristics and outcomes of 2-DTC remain poorly understood. Objective We aimed to explore the 2-DTC. Methods retrospectively analyzed data from Surveillance, Epidemiology, End Results (SEER) database (2000-2017). was divided into 25 subgroups based on prior malignancies (PPMs). Baseline were compared using chi-square test. Multivariable logistic analysis...
An increasing amount of evidence has demonstrated the importance microRNAs (miRNAs/miRs) in tumorigenesis malignant types cancer, and data retrieved from The Cancer Genome Atlas database revealed that miR-3690 was upregulated thyroid cancer (TC). present study focused on biological function mechanism TC, demonstrating expression significantly elevated TC cells clinical tissues. Functional studies indicated acted as an oncogene by promoting cell proliferation, colony formation cycle...
Abstract Problem Anti‐Ro/SSA and/or anti‐La/SSB (anti‐SSA/SSB) antibodies impair pregnancy outcomes, including embryo implantation and maintenance. Optimal endometrial immune status is essential for successful pregnancy. However, whether these affect still unclear. Menstrual blood can be collected non‐invasively, differs from peripheral blood, reflect the status. We herein focused on changes in subsets of natural killer (NK) cells T menstrual blood. Methods study samples anti‐SSA/SSB...
Objective To investigate the stimulated proliferation of colon cancer cells in co-cultures regenerating hepatocytes. Methods Regenerating hepatocytes(24 hours after partial hepatectomy)were obtained by collagenase perfusion models rats undergoing 70% liver resection. determine whether ratio human cell line SW480 to hepatocytes has influence on their interaction,these were cultured ratios 1: 101:1, or 10: 1. Proliferation capacity was assessed percentage 3 H-TdR incorporation. Expression...
Objective To investigate the selective apoptosis-inducing effect of adeno-associated virus mediated gene transfer MDA-7 regulated by PEG promoter on human hepatocellular carcinoma cells.Methods We transduced cell line HepG2 and normal hepatocytes LO2 with rAAV-PEG-MDA-7 assessed growth inhibition,cell cycle apoptosis.MDA-7 protein was detected Western blotting,cell growth-inhibiting rate evaluated MTT cycle, Annexin-Ⅴ labeling mitochondrial transmembrane potential were determined flow...