A5004676510- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Nutrition, Health and Food Behavior
- Garlic and Onion Studies
- Phytoestrogen effects and research
- Agriculture, Soil, Plant Science
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Cholinesterase and Neurodegenerative Diseases
- Seaweed-derived Bioactive Compounds
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Fatty Acid Research and Health
- Sphingolipid Metabolism and Signaling
- Medicinal Plants and Neuroprotection
- Meat and Animal Product Quality
- Eicosanoids and Hypertension Pharmacology
- Enzyme function and inhibition
- Natural Antidiabetic Agents Studies
- GABA and Rice Research
- Fermentation and Sensory Analysis
- Biochemical effects in animals
- Ginseng Biological Effects and Applications
- Antioxidant Activity and Oxidative Stress
- Protein Hydrolysis and Bioactive Peptides
Chungnam National University
2013-2025
Seoul National University
2025
Mokwon University
2018-2024
National NanoFab Center
2021
Food & Nutrition
2007-2016
Food and Nutrition Service
2014
Silla University
2010
Food Research Institute
2010
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2008
Korea Polar Research Institute
2008
N-acetyl serotonin (NAS) as a melatonin precursor has neuroprotective actions. Nonetheless, it is not clarified how NAS protects neuronal cells against oxidative stress. Recently, we have reported that N-palmitoyl serotonins possessed properties of antioxidants and neuroprotection. Based on those, hypothesized NAS, N-acyl serotonin, may similar actions in stress-induced cells, examined the effects based vitro vivo tests. dose-dependently inhibited cell death HT-22 cells. Moreover, suppressed...
Aims: The nature of villitis unknown aetiology (VUE) is intriguing in terms its aetiology, origin inflammatory cells and immunophenotype T involved. aim was to determine the macrophages lymphocytes VUE associated with various complications pregnancy. Methods results: Placentas ( n = 45) were studied by chromogenic in‐situ hybridization (CISH) for Y chromosome (DYZ1) immunohistochemistry CD14, CD68, Ki67 10; all from male neonates) a panel T‐cell antigens (CD3, CD4 CD8) 35). All placentas...
ABSTRACT: Effect of gamma‐irradiation on color, pungency, and volatiles Korean red pepper powder ( Capsicum annuum L.) was investigated. Red powder, vacuum‐packaged in a polyethylene/polypropylene bag, gamma‐irradiated up to 7 kGy. An irradiation dose kGy reduced the population mesophilic bacteria fungi effectively without affecting major quality factors. Pungency irradiated not changed based amount capsanoids by high‐performance liquid chromatography (HPLC) Scoville sensory score. The color...
The anti-atherogenic effects of spirulina (Spirulina platensis) were investigated in the New Zealand White (NZW) rabbit model. animal had hypercholesterolemia induced by being fed a high cholesterol diet (HCD) containing 0.5% for 4 wk, and then HCD supplemented with 1 or 5% (SP1 SP5) an additional 8 wk. Spirulina supplementation lowered intimal surface aorta 32.2 to 48.3%, compared HCD. Serum triglyceride (TG) total (TC) significantly reduced SP groups. After serum low density lipoprotein...
Abstract We present co-seismic displacement vectors derived from Global Positioning System (GPS) measurements of 92 stations in southern California. These GPS results are combined with five well-determined continuously tracking the Permanent Geodetic Array, as well line-length changes USGS Geodolite and two-color laser trilateration observations, to determine a self-consistent set geodetic data for earthquake. displacements modeled by an elastic dislocation representation primary fault...
An EtOAc-soluble partition of the MeOH extract a branch Tetracera scandens (Dilleniaceae family) was subjected to glucose-uptake assay, which led isolation and identification five isoflavones previously known structure namely, genistein (1), its derivatives 3′,5′-diprenylgenistein (2), 6,8-diprenylgenistein (3), derrone (4) alpinumisoflavone (5). Of these, compounds 2—5 exhibited significant activity in basal insulin-stimulated L6 myotubes. The findings from adenosine monophosphate-activated...
The hepatoprotective effect of aged black garlic (ABG) against ethanol-induced oxidative liver damage was investigated in adult male Sprague–Dawley rats for 4 weeks. Rats were divided into three groups: a saline (WT) group, an ethanol (ET) group (15 mL/kg body weight 20% [wt/vol] ethanol), and + ABG (ET+ABG) (ethanol 100 mg/kg ABG). administration led to decreased epididymal total fat pad (P<.05) weights, ameliorated prominent fatty changes around the portal triad, reduced accumulation...
Antioxidants are an important group of medicinal preventive compounds as well being food additives inhibiting detrimental changes easily oxidizable nutrients. The present investigation has been carried out to evaluate the antioxidant properties different solvent extracts Agriophyllum pungens seeds by various in vitro systems. anti-oxidative activities these samples were determined using four methods: 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)...
Garlic (Allium sativum) has been used as a food well component of traditional medicine. Aged black garlic (ABG) is known to have various bioactivities. However, the effect ABG on allergic response almost unknown. In present study, we investigated whether can inhibit immunoglobulin E-mediated in RBL-2H3 cells vivo passive cutaneous anaphylaxis (PCA). vitro tests, ethyl acetate extract (EBG) significantly inhibited release β-hexosaminidase (IC₅₀, 1.53 mg/mL) and TNF-α 0.98 mg/mL). Moreover,...
The dopamine precursor l -3,4-dihydroxyphenylalanine ( -DOPA) is widely used as a therapeutic choice for the treatment of patients with Parkinson's disease. However, long-term use -DOPA leads to development debilitating involuntary movements, called -DOPA-induced dyskinesia (LID). cAMP/protein kinase A (PKA) signaling in striatum known play role LID. from among nine adenylyl cyclases (ACs) present striatum, AC that mediates LID remains unknown. To address this issue, we prepared an animal...
3,3'-Diindolylmethane (DIM), a metabolite of indole-3-carbinol present in Brassicaceae vegetables, possesses various health-promoting effects. Nonetheless, the effect DIM on neurodegenerative diseases has not been elucidated clearly. In this study, we hypothesized may protect neuronal cells against oxidative stress-induced apoptosis by promoting formation brain-derived neurotrophic factor (BDNF) and antioxidant enzymes through stabilizing activation tropomyosin-related kinase receptor B...
Lysophosphatidylcholine is known to be a lipid mediator in various cellular responses. In this study, we examined the anti-inflammatory actions of lysophosphatidylcholine containing docosahexaenoic acid esterified at sn-1 position. First, RAW 264.7 cells, DHA-lysoPtdCho suppressed LPS-induced formation NO concentration-dependently. However, ARA-lysoPtdCho showed partial suppression, and LNA-lysoPtdCho had no significant effect. Additionally, also reduced level TNF-alpha or IL-6, but not...
Abstract In the present study, anti‐inflammatory action of lysophosphatidylethanolamine (lysoPtdEtn), orally administered, in zymosan A‐induced peritonitis was examined. Oral administration 2‐DHA‐lysoPtdEtn (ED 50 , ~111 μg/kg) or 2‐ARA‐lysoPtdEtn 221 found to inhibit plasma leakage mice treated with A. support this, 2‐polyunsaturated acyl‐lysoPtdEtn diminished formation LTC 4 a lipid mediator responsible for vascular permeability. Next, 110 123 effectively inhibited leukocyte extravasation...
In this study, the anti-inflammatory and antisepticemic activities of a water extract aged black garlic (AGE), which is not pungent, were compared with those raw (RGE). The methyl thiazolyl tetrazolium (MTT) assay showed that AGE was toxic up to 1000 μg/mL at least four times less cytotoxic than RGE. significantly suppressed production nitric oxide (NO), tumor-necrosis factor-α (TNF-α), prostaglandin (PG)-E2 in dose-dependent manner lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages....
Although mulberry fruit has various beneficial effects, its effect on diabetes-related dementia remains unknown. We investigated whether the ethyl acetate fraction of ethanolic extract (MFE) could alleviate biochemical and behavioral deficits in alloxan-induced diabetic mice. In mice, MFE considerably abolished multiple deficits, e.g., body weight reduction; water food intake increase; hyperglycemia, hyperlipidemia, hypoinsulinism, hypertrophy liver, kidneys, spleen, brain. A 200 mg/kg dose...
Enteromorpha prolifera, a green alga, has long been used in food diets as well traditional remedies East Asia. Our preliminary study demonstrated that an ethyl acetate extract of prolifera (EAEP) exhibited the strongest antioxidant activity compared to ethanol or water extracts. Nonetheless, there no report on effect EAEP memory impairment due oxidative damage. This investigated whether could attenuate deficits stress-induced mouse model. was orally administered (50 100 mg/kg body weight...
The effect of diet supplemented with red beet (Beta vulgaris L.) leaf on antioxidant status plasma and tissue was investigated in C57BL/6J mice. mice were randomly divided into two groups after one-week acclimation, fed a high fat (20%) cholesterol (1%) without (control group) or 8% freeze-dried (RBL for 4 weeks. In RBL mice, lipid peroxidation determined as 2-thiobarbituric acid-reactive substances (TBARS value) significantly reduced the selected organs (liver, heart, kidney). Levels...
Plant extracts contain a huge variety of pharmacologically active substances. Conventionally, various chromatographic methods must be applied several times to purify functional compounds measure their activity. However, conventional purification are time-consuming and expensive due the laborious process. Recently, high-throughput discovery method that replaces such processes was introduced; this uses 15 T ultra-high-resolution Fourier transform ion cyclotron resonance mass spectrometry (15...