A5059071043- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- interferon and immune responses
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Nanoparticle-Based Drug Delivery
- Phagocytosis and Immune Regulation
- Wound Healing and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Chronic Kidney Disease and Diabetes
- Antiplatelet Therapy and Cardiovascular Diseases
- Pressure Ulcer Prevention and Management
- MicroRNA in disease regulation
- Diabetic Foot Ulcer Assessment and Management
- Liver Disease and Transplantation
- Inflammasome and immune disorders
West China Hospital of Sichuan University
2017-2025
Shanghai University of Traditional Chinese Medicine
2013-2025
Sichuan University
2017-2025
Zhejiang Shuren University
2025
Shuguang Hospital
2012-2024
Fourth People's Hospital of Sichuan Province
2024
The Fourth People's Hospital
2024
Hunan Normal University
2021-2023
Hunan Provincial People's Hospital
2021-2023
Southern Medical University
2019-2022
Hepatocellular carcinoma (HCC) resistant to both chemotherapy and immunotherapy is among the deadliest malignancies. Doxorubicin widely used in transarterial HCC can induce immunogenic cell death (ICD), but resulting immunogenicity still weak. We aim seek a strategy for improving efficacy of ICD based on an immunoregulatory drug called icaritin. Icaritin induced mitophagy apoptosis provoke mouse Hepa1-6 human Huh7 cells. A combination icaritin doxorubicin with molar ratio 1:2 played...
FOLFOX, the combinational strategy of folinic acid (FnA), 5-fluorouracil (5-Fu), and oxaliplatin (OxP), has been used as standard treatment colorectal cancer (CRC) for decades. Despite improved survival, patients still suffer from drawbacks such low efficacy, high toxicity, long course treatment. New strategies to address these issues are needed further clinical benefits. In this study, a nanoprecipitate (C26H35N9O7Pt) was formed by active form OxP ([Pt(DACH)(H2O)2]2+) FnA, which formulated...
The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety cancers, efficacy inhibitors is still low in colorectal (CRC). This mainly due to immunosuppressive feature tumor microenvironment (TME). Emerging evidence reveals that certain chemotherapeutic drugs induce immunogenic cell death (ICD), demonstrating potential remodeling TME. In this study, ginsenoside Rg3 (Rg3) as an ICD inducer against CRC...
The polarization of tumor-associated macrophages (TAMs) from M2 to M1 phenotype demonstrates great potential for remodeling the immunosuppressive tumor microenvironment (TME) hepatocellular carcinoma (HCC). d-lactate (DL; a gut microbiome metabolite) acts as an endogenous immunomodulatory agent that enhances Kupffer cells clearance pathogens. In this study, DL transformation TAMs was confirmed, and mechanisms underlying such were mainly due modulation phosphatidylinositol 3-kinase/protein...
Abstract Background FOLFOX is a combinational regimen of folinic acid (FnA, FOL ), fluorouracil (5-Fu, F ) and oxaliplatin (OxP, OX has been long considered as the standard treatment colorectal cancer (CRC) hepatocellular carcinoma (HCC). Recent developments nano delivery systems have provided profound promise for improving anticancer efficacy alleviating side effects FOLFOX. Previously, nanoformulation (termed Nano-Folox) containing OxP derivative FnA was developed in our laboratory using...
Background Immunotherapy for hepatocellular carcinoma (HCC) exhibits limited clinical efficacy due to immunosuppressive tumor microenvironment (TME). Tumor-infiltrating macrophages (TIMs) account the major component in TME, and dominance of M2 phenotype over M1 TIMs plays pivotal role sustaining character. We thus investigate effect bufalin on promoting polarization toward improve HCC immunotherapy. Methods The impact evoking antitumor immune response was evaluated immunocompetent mouse...
Abstract Background Hepatocellular carcinoma (HCC) developed in fibrotic liver does not respond well to immunotherapy, mainly due the stromal microenvironment and fibrosis-related immunosuppressive factors. The characteristic of sinusoidal endothelial cells (LSECs) contributing fibrosis orchestrating immune response is responsible for refractory targeted therapy or immunotherapy HCC. We aim seek a new strategy HCC treatment based on an old drug simvastatin which shows protecting effect LSEC....
Summary Background Metabolic syndrome is a known risk factor of cirrhosis in chronic hepatitis B ( CHB ). Aim To investigate the effects coincidental metabolic on liver fibrosis progression treatment‐naïve patients. Methods A total 1466 patients underwent stiffness measurement LSM ) by transient elastography 2006–2008; 663 remained and had second 2010–2012. Liver was defined as an increase ≥30% at assessment. The impact its factors were evaluated after adjustment for viral load activity....
The impaired wound healing in diabetes is a central concern of healthcare worldwide. However, current treatments often fail due to the complexity diabetic wounds, and thus, emerging therapeutic approaches are needed. Macrophages, prominent immune cell wound, play key roles tissue repair regeneration. Recent evidence has demonstrated that macrophages wounds maintain persistent proinflammatory phenotype causes failure healing. Therefore, modulation provides great promise for patients. In this...
Hepatocellular carcinomas (HCC) exhibit distinct promoter hypermethylation patterns, but the epigenetic regulation and function of transcriptional enhancers remain unclear. Here, our affinity- bisulfite-based whole-genome sequencing analyses reveal global enhancer hypomethylation in human HCCs. Integrative epigenomic characterization further pinpoints a recurrent hypomethylated CCAAT/enhancer-binding protein-beta (C/EBPβ) which correlates with C/EBPβ over-expression poorer prognosis...
Background: Nonalcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic diseases worldwide. At present, there are no effective pharmacological therapies for NAFLD except lifestyle intervention-mediated weight loss. Atractylenolide III (ATL III), major bioactive component found in Atractylode smacrocephala Koidz, has been shown to exert anti-oxidant, anti-tumor, anti-allergic response, anti-bacterial effects and cognitive protection. Here we investigate therapeutic...
The antioxidant activity of natural products is closely related to their antiglycation effects. This study aimed examine the and elucidate underlying mechanisms two specific peptides, EDYGA (Glu-Asp-Tyr-Gly-Ala) DLLCIC (Asp-Leu-Leu-Cys-Ile-Val), derived from protein hydrolysates Pelodiscus sinensis . Both were efficient in bovine serum albumin (BSA)/glucose model inhibit BSA glycation, while showed higher than EDYGA. Firstly, it was found that could formation NEG AGEs. Moreover, able...
Background & AimsAberrant chromatin modification is a key feature of hepatocellular carcinoma (HCC), which characterized by strong sexual dimorphism. Both enhancer zeste homolog 2 (EZH2) and cell cycle-related kinase (CCRK) contribute to hepatocarcinogenesis, yet whether the two oncogenic factors have functional crosstalk unknown.MethodsCellular proliferation tumorigenicity upon transgenic expression RNA interference were determined colony formation soft agar assays, xenograft, orthotopic...
Tumor cells often exist in a hypoxic microenvironment, which produces acidic metabolites. To survive this harsh environment, tumor must exhibit dynamic cytosolic pH regulatory system. Vacuolar H(+)-adenosine triphosphatase (V-ATPase) is considered to play an important role the regulation of microenvironment some tumors. In study, we made investigation on expression and functional V-ATPase native human hepatocellular carcinoma (HCC). The results showed that messenger RNA protein levels...
Summary Background The accuracy of Enhanced Liver Fibrosis ( ELF ; ADVIA Centaur, Siemens Healthcare Diagnostics, Tarrytown, NY , USA ) in assessing liver fibrosis chronic hepatitis B CHB is to be determined. Aim To derive and validate a combined ‐liver stiffness measurement LSM algorithm predict advanced patients. Methods Using the data previously reported cohort 238 patients, an ALT ‐based for was used as training evaluate performance against histology. best ‐ then validated new 85...