A5078221416- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Ultrasound and Cavitation Phenomena
- Liver Disease Diagnosis and Treatment
- Ultrasound Imaging and Elastography
- Drug Transport and Resistance Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Phagocytosis and Immune Regulation
- Ubiquitin and proteasome pathways
- Pancreatitis Pathology and Treatment
- Adenosine and Purinergic Signaling
- Inflammasome and immune disorders
- Pharmacological Effects of Natural Compounds
- Immune cells in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver physiology and pathology
- interferon and immune responses
- Andrographolide Research and Applications
- Cholesterol and Lipid Metabolism
- Metabolism and Genetic Disorders
- COVID-19 Clinical Research Studies
Shanghai University of Traditional Chinese Medicine
2023-2024
Shuguang Hospital
2023-2024
Columbia University
2017-2020
Abstract Brain diseases including neurological disorders and tumors remain under treated due to the challenge access brain, blood-brain barrier (BBB) restricting drug delivery which, also profoundly limits development of pharmacological treatment. Focused ultrasound (FUS) with microbubbles is sole method open BBB noninvasively, locally, transiently facilitate delivery, while translation clinic challenging long procedure, targeting limitations, or invasiveness current systems. In order...
Focused ultrasound with nanodroplets could facilitate localized drug delivery after vaporization potentially improved in vivo stability, payload, and minimal interference outside of the focal zone compared microbubbles. While feasibility blood-brain barrier (BBB) opening using has been previously reported, characterization associated not achieved. It was hypothesized that outcome droplet's sensitivity to acoustic energy, can be modulated boiling point liquid core. Therefore, this study,...
Passive acoustic mapping enables the spatiotemporal monitoring of cavitation with circulating microbubbles during focused ultrasound (FUS)-mediated blood-brain barrier opening. However, computational load for processing large data sets maps or more complex algorithms limit visualization in real-time treatment and adjustment. In this study, we implemented a graphical unit (GPU)-accelerated sparse matrix-based beamforming time exposure acoustics neuronavigation-guided system cavitation. The...
Hepatocyte nuclear factor 1β (HNF1β) is essential for biliary development, while its genetic defect triggers the dysplasia of interlobular bile ducts, leading to life-threatening hepatitis and cholestasis. To date, this disorder has mainly been documented in neonates. Here, we report a case cholestasis an adult patient caused by de novo HNF1β mutation. A liver biopsy revealed remarkable shrinkage portal area accompanied decrease or absence veins, arteries area. Our showed that could induce...
We reported a case of recurrent liver dysfunction in an adult patient with history abnormal enzymes persisting for over ten years. The primary abnormalities included elevated levels gamma-glutamyl transferase and alkaline phosphatase. Despite conducting series extensive etiological tests to identify common causes disease, the diagnosis remained unclear. However, whole-exome next-generation sequencing revealed homozygous intronic mutation ferrochelatase gene (c.315-48T>C), which may be...
Focused ultrasound with nanodroplets could facilitate localized drug delivery after vaporization potentially improved in vivo stability, payload, and minimal interference outside of the focal zone compared microbubbles. While feasibility blood-brain barrier (BBB) opening using has been previously reported, characterization associated not achieved. It was hypothesized that outcome droplet sensitivity to acoustic energy, can be modulated boiling point liquid core. Therefore, this study,...
Abstract Objectives: This study aimed to assess the effectiveness of a Chinese patent medicine called ZhengQi tablet in treatment mild COVID-19 patients. Methods: A prospective cohort trial was carried out mobile cabin hospital City Footprint Hall Shanghai ( ChiCTR2200058693 ). total 800 patients were enrolled this clinical and assigned receive 7 days with (ZQT group) or TCM placebo (control by oral administration per day. The nucleic acid conversion rate SARS-CoV-2 percentage subjects who...
Acoustically-activated nanodroplets facilitate localized drug delivery after vaporization with improved in vivo stability, payload, and minimal interference outside of the ultrasound focal zone compared microbubbles. They are new acoustic mediators to induce blood-brain barrier (BBB) opening for brain, promising potential extravasation enhance targeted extravascular space due nano sizes.