A5102911422- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Pharmacogenetics and Drug Metabolism
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Hepatitis B Virus Studies
- Alcohol Consumption and Health Effects
- Pancreatitis Pathology and Treatment
- Drug Transport and Resistance Mechanisms
- Epilepsy research and treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Peroxisome Proliferator-Activated Receptors
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- Tracheal and airway disorders
- Treatment of Major Depression
- Cancer, Hypoxia, and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Airway Management and Intubation Techniques
- Malaria Research and Control
- Hepatitis C virus research
- Lipid metabolism and disorders
- Chromatography in Natural Products
Sun Yat-sen University
2010-2025
The First Affiliated Hospital, Sun Yat-sen University
2010-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Anhui Medical University
2022-2024
South China Agricultural University
2024
Anhui Mental Health Center
2021-2023
Shandong First Medical University
2021-2022
Shandong Provincial Hospital
2021-2022
Yunnan University of Traditional Chinese Medicine
2022
Shandong University
2018-2020
BackgroundTraditional classification systems of metabolic-associated fatty liver disease (MAFLD) do not account for the high rate extrahepatic complications. To create a new MAFLD using metabolic parameters to identify risks complications more accurately.MethodsThe retrospective study included patients from First Affiliated Hospital Sun Yat-sen University model development, and was validated respectively Chinese cohort UK Biobank database. Cluster analysis with k-means cluster built age,...
As the nonalcoholic fatty liver disease (NAFLD) epidemic matures, understanding how metabolic changes in NAFLD development vary over age distribution is important to guide precise prevention. We aimed clarify trends age-specific incidence.We conducted a 4-year longitudinal retrospective cohort study enrolling 10,240 consecutive healthy individuals who received annual physical examination during 2012-2019. Baseline and dynamic metabolism hepatic steatosis determined with ultrasound were...
Abstract Objective Accumulating evidence supports the idea that inflammation may contribute to pathophysiology of major depressive disorder (MDD). Duloxetine, a serotonin-norepinephrine reuptake inhibitor, exhibits anti-inflammatory effects both in vitro and vivo. In this study, we investigated impact duloxetine on changes serum proinflammatory cytokine levels among individuals diagnosed with MDD. Methods A cohort 23 drug-naïve MDD healthy controls were included study. The severity symptoms...
Myostatin (MSTN) is a member of the transforming growth factor-β superfamily that negatively regulates skeletal muscle development and growth. In present study, partial genomic fragments MSTN were screened for single nucleotide polymorphisms (SNPs) in selected common carp individuals from wild populations, two SNPs intron 2 (c.371 + 749A > G, c.371 781T C) synonymous exon 3 (c.42A c.72C T) identified. Genotyping by direct sequencing polymerase chain reaction (PCR) products these four...
Serum uric acid (SUA) is regarded as an independent risk factor for nonalcoholic fatty liver disease (NAFLD). However, the role of SUA in new diagnosis flowchart metabolic-associated (MAFLD) remains unclear. A cross-sectional study enrolled consecutive individuals with ultrasonography and magnetic resonance imaging−based proton density fat fraction (MRI-PDFF) measurements First Affiliated Hospital Sun Yat-sen University from January 2015 to December 2021. All patients were divided into four...
Abstract Objective It is known that cytokines play a role in both depression and anxiety. This study aimed to compare the levels of multiple patients with first-episode drug-naive major depressive disorder (MDD) or without anxiety analyze correlation between level serum cytokine levels. Methods The involved 55 MDD. To assess symptoms, 14-item HAMA was used. MDD were divided into two groups: 23 32 measurement 37 conducted. Serum compared. In linear regression models, relationship group...
Objective Major Depressive Disorder (MDD) is a leading cause of disability, with high risk suicidal ideation (SI). Few studies have evaluated the potential multiple cytokines as biomarkers for SI in patients MDD. In present study, we examined serum levels first-episode drug-naïve MDD, aim to discover and identify cytokines-based identification Methods A total 55 MDD were enrolled divided into two groups: 26 without 29 SI. Beck Scale Suicide Ideation was used estimate 37 measured using...
Alkaloids, a class of low-molecular-weight nitrogenous compounds, attract great deal interest because their biological activities and therapeutic potential. Yet, surprisingly little is known about interactions with drug transporters, especially Organic Anion Transporting Polypeptide 1B1 (OATP1B1), liver-specific uptake transporter, which closely associated drug-induced liver injury (DILI). This study aims to investigate the inhibitory effects 160 alkaloids on OATP1B1, assess hepatoprotective...
Background The unexpectedly increased burden of metabolic-associated fatty liver disease (MAFLD) continues in China, and the differences between rural urban areas remain unclear. We aimed to clarify prevalence risk factors China. Methods This cross-sectional study used most densely populated area with highly unbalanced development China (Guangdong Province) as a representative sample, multistage stratified random sampling was performed. participants’ demographic, socioeconomic lifestyle data...
Abstract Background Falls are an important cause of injury and death older people. Hence, analyzing the multifactorial risk falls from past cases to develop intervention programs is clinically significant. However, due small sample size, there few studies on fall analysis clinical characteristics fallers, especially among hospitalized patients. Methods We collected data 153 inpatients who fell (age ≥ 60 years) hospital nursing adverse event reporting system during hospitalization at Shandong...
Purpose: Effective treatment of dyslipidemia with lipid-lowering agents is pivotal in the management metabolic-associated fatty liver disease (MAFLD) for preventing cardiovascular complications. We explored associations between improvements injuries indicated by changes transaminases and a reduction lipid levels MAFLD patients elevated during therapies. Methods: This prospective, cohort study enrolled consecutive hyperlipidemia transaminases. Patients were divided into group receiving an...
Evidence indicates a potential role of chemokines in depression-like behavior and depression-related pathophysiological processes. In the present study, we examined serum levels multiple chemokines, focusing on CC patients with major depressive disorder (MDD), aim to discover identify chemokines-based biomarkers for MDD diagnosis.Participants included 24 healthy controls. The 24-item Hamilton Depression Rating Scale (HAMD-24) was administered assess disease severity MDD. A total 9 including...
Protracted alcohol withdrawal symptoms (PAWS), characterized by the presence of substance-specific signs and (including anxiety, irritability, mood instability, insomnia, cravings), make abstinence difficult increase risk relapse in recovering alcoholics. The goal this study was to evaluate effect transcutaneous auricular vagus nerve stimulation (taVNS) on PAWS plasma brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), leptin levels patients with...
Abstract Background The normalization of liver biochemical parameters usually reflects the histological response to treatment for nonalcoholic fatty disease (NAFLD). Researchers have not clearly determined whether different enzymes exhibit various metabolic changes during follow-up period in patients with NAFLD. Methods We performed a retrospective analysis NAFLD who were receiving therapy from January 2011 December 2019. Metabolism indexes, including glucose levels, lipid profiles, uric...
Gene-centromere (G-C) mapping provides insights into structural and behavioural properties of chromosomes. In this study, G-C using microsatellite markers meiogynogenetic (meiotic gynogenetic) families were performed in bighead carp (Aristichthys nobilis, 2N = 48), which belongs to Cyprinidae. A total 218 microsatellites selected across 24 linkage groups (LGs) a recently well-defined genetic map for carp, with 151 being heterozygous at least one six dams diploid families. After tests...
Shenxian-shengmai (SXSM) oral liquid, a Chinese patent compound medicine, has been used to treat sinus bradyarrhythmias induced by mild sick syndrome in clinical practice. Myocardial ischemia, particular serious or right coronary-related heart diseases, can cause and cardiac dysfunction. Moreover, reperfusion of ischemic myocardium is associated with additional myocardial damage known as ischemia-reperfusion (I/R) injury. This study was designed evaluate the effects SXSM on dysfunction I/R...