A5101263286- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Nutrition and Health in Aging
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Metabolism, Diabetes, and Cancer
- Heart Failure Treatment and Management
- Gut microbiota and health
- Cardiovascular Function and Risk Factors
- Vibration Control and Rheological Fluids
- Video Surveillance and Tracking Methods
- Human Pose and Action Recognition
- Immunotherapy and Immune Responses
- Cardiac Structural Anomalies and Repair
- GDF15 and Related Biomarkers
- Pancreatic function and diabetes
- Geochemistry and Elemental Analysis
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Oral and gingival health research
- Esophageal Cancer Research and Treatment
- Genetics and Neurodevelopmental Disorders
- Tribology and Wear Analysis
Guangdong Provincial People's Hospital
2019-2025
Guangdong Academy of Medical Sciences
2015-2025
Guangdong University of Technology
2022-2025
Southern Medical University
2021-2024
421 Hospital of PLA
2024
South China University of Technology
2024
Northeast Agricultural University
2022
City University of Macau
2021
University of Macau
2021
Guangdong General Hospital
2010-2018
Pancreatic ductal adenocarcinoma (PDAC) is characterised by immune evasion that contribute to poor prognosis. Cancer-associated fibroblasts (CAFs) play a pivotal role in orchestrating the PDAC tumour microenvironment. We investigated of CAF-derived extracellular vesicle (EV)-packaged long non-coding RNAs (lncRNAs) and explored gene therapy using engineered EVs loading small interfering (siRNAs) as potential therapeutic strategy. Our findings highlight significance EV-packaged lncRNA...
Liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, has been demonstrated to reduce hepatic steatosis. However, the mechanism of lipid-lowering effect liraglutide in liver remains unclear. The aim present study was investigate beneficial on diet-induced non-alcoholic fatty disease (NAFLD) and underlying rats. NAFLD induced Sprague-Dawley rats by feeding high fat cholesterol (HFHC) diet. Liraglutide (0.6 mg/kg body weight/d) injected intraperitoneally subjected HFHC diet four weeks...
Introduction: There is growing evidence of research indicating that the gut microbiota involved in development sarcopenia. Nevertheless, there exists a notable deficiency comprehension concerning connection between irregularities intestinal microbiome and metabolic processes older individuals suffering from Methods: To analyze fecal samples obtained cohort 30 patients diagnosed with sarcopenia as well without sarcopenia, this study employed 16S rDNA sequencing liquid chromatography-mass...
Purpose: There is mounting evidence to indicate that microRNA-17 (miR-17) expressed and functionally involved in human cancers. However, the molecular mechanism underlying role of miR-17 colorectal cancer (CRC) remains largely unclear. This study aims reveal biological function cancer. Materials methods: The expression CRC cells tissues was examined using qRT-PCR. Cell proliferation migration assays were performed after transfection with an mimic inhibitors. potential gene targets predicted...
Nonobese metabolic dysfunction-associated fatty liver disease (MAFLD) is paradoxically associated with improved and pathological features at diagnosis but similar cardiovascular diseases (CVD) prognosis to obese MAFLD. We aimed utilize the metabolomics identify potential metabolite profiles accounting for this phenomenon.This prospective multicenter cross-sectional study was conducted in China enrolling derivation validation cohorts. Liquid chromatography coupled mass spectrometry gas...
This study explores the synthesis of bio‐lubricants derived from palm oil, highlighting its potential as a sustainable alternative to petroleum‐based lubricants. Through epoxidation and subsequent ring‐opening reactions using isoamyl alcohol, palmitic acid esters (PAE), with enhanced thermal oxidative stability was developed. Optimal reaction conditions, identified 100 °C p‐toluenesulfonic catalyst. The synthesized bio‐lubricant PAE, exhibited superior tribological performance, achieving...
Gastric cancer is a common tumor type associated with nutritional and immune status. The aim of the current study was to investigate prognostic value preoperative index (PNI), composed factors in elderly patients undergoing gastric surgery.A total 454 surgery were divided into two groups based on PNI scores: ≤45.1 (n = 307) >45.1 147). Survival analysis performed using Kaplan-Meier method Log rank tests. Univariate multivariate analyses conducted identify independent Cox proportional hazards...
Aims Hypoalbuminemia was extensively used to diagnose malnutrition in older adults. Malnutrition associated with mortality elderly patients cardiovascular diseases. The relationship between hypoalbuminemia and clinical outcomes nonischemic dilated cardiomyopathy (NIDCM) remains unknown. Methods A total of 1058 consecutive NIDCM (age ≥60 years) were retrospectively enrolled from January 2010 December 2019. Univariate multivariate analyses performed assess the association outcomes. Results...
BarH‑like homeobox 2 (BARX2), a gene, is associated with several types of cancers. The present study aimed to determine whether DNA methylation downregulates BARX2 expression and suppression gastric carcinogenesis. protein in normal cancerous tissues various cancer (GC) cell lines was detected using immunohistochemical western blot assays. mRNA levels were both reverse transcription‑polymerase chain reaction (RT‑PCR) quantitative PCR (qPCR). Promoter hypermethylation GC cells...
Background: It is unclear whether serum calcium on admission associated with clinical outcomes in dilated cardiomyopathy (DCM). In this study, we conducted a retrospective study spanning decade to investigate the prognostic value of baseline elderly patients DCM. Methods: A total 1,089 consecutive (age ≥60 years) diagnosed DCM were retrospectively enrolled from January 2010 December 2019. Univariate and multivariate analyses performed association their outcomes. Results: average age subjects...
The inherent drawbacks of the conventional B-mode ultrasound for metabolic dysfunction-associated steatotic liver disease (MASLD) are poorly understood. We aimed to investigate impact factors and optimize screening performance in MASLD. In a prospective pilot cohort recruited from July 2020 January 2022, subjects who had undergone magnetic resonance imaging-based proton density fat fraction (MRI-PDFF), ultrasound, laboratory test-based assessments were included deprivation cohort. A...
The present study aimed to investigate whether c-mesenchymal epithelial transition factor (C-MET) overexpression combined with RAS (including KRAS, NRAS and HRAS) or BRAF mutations were associated late distant metastases the prognosis of patients colorectal cancer (CRC). A total 374 stage III CRC classified into 4 groups based on RAS/BRAF C-MET status for comprehensive analysis. Mutations in determined using Sanger sequencing expression was examined immunohistochemistry. associations between...
To identify functional proteins involved in pancreatic-duodenal homeobox-1 (PDX1)-mediated effects on gastric carcinogenesis.A PDX1-overexpressed model was established by transfecting cancer cell line SGC7901 with pcDNA3.1(+)-PDX1 vector (SGC-PDX1). Transfection empty pcDNA3.1 (SGC-pcDNA) served as control. Comparative protein profiles of the two groups were analyzed two-dimensional electrophoresis based-proteomics (2DE gel-based proteomics). The differential identified 2DE further validated...
This article is about object tracking based on graph modeling. Object usually initialized by detection methods. The fundamental hypothesis that the object's pattern can be separated from its surrounding background sufficiently. However, for some objects, e.g., ball in broadcast soccer videos, it hard to extract effective features detect a single video frame. strategy adopted here identify candidate regions several consecutive frames, and then use construct relationship between regions....
Abstract Background Various biomarkers associated with sarcopenia have been identified. However, there is a scarcity of studies exploring and validating in individuals age-related sarcopenia. Aims This study aimed to investigate the proteome identify potential for Methods Proteomic analysis experimental validation were conducted using plasma from hospitalized older adults. Sarcopenia diagnosis was based on Asian Working Group 2019 criteria. Data-independent acquisition-based proteomics...
Because the vibration of buildings and bridges is often small in amplitude, low frequency, wide frequency bandwidth, designing a conventional energy harvester with natural enough to coincide excitation usually accompany very large mass volume. However, it important use portable (usually higher frequency) obtain for wireless devices. If harvesters were used directly on high-rise buildings, efficiency would be low. To solve this problem, we propose simple device implement building application...