A5081434113- Mesenchymal stem cell research
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Antibiotic Resistance in Bacteria
- Metabolomics and Mass Spectrometry Studies
- Cancer, Lipids, and Metabolism
- Urinary Tract Infections Management
- Autophagy in Disease and Therapy
- Tissue Engineering and Regenerative Medicine
- Hydrological Forecasting Using AI
- Cancer, Hypoxia, and Metabolism
- Phytase and its Applications
- Asthma and respiratory diseases
- Sphingolipid Metabolism and Signaling
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Protein Kinase Regulation and GTPase Signaling
- Lipoproteins and Cardiovascular Health
- Machine Learning in Healthcare
- Acute Kidney Injury Research
- Mycobacterium research and diagnosis
- Phagocytosis and Immune Regulation
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
Ningbo Medical Center Lihuili Hospital
2012-2025
Ningbo University
2023-2025
Southern Medical University
2023
Guangdong Academy of Medical Sciences
2023
Guangdong Provincial People's Hospital
2023
Taipei Medical University
2019
Fu Wai Hospital
2007-2009
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2009
Abstract Bone marrow-derived mesenchymal stem cells (MSCs) have shown great promise for cardiac repair. However, poor viability of transplanted MSCs within the ischemic heart has limited their therapeutic potential. Our previous studies documented that hypoxia and serum deprivation (hypoxia/SD), induced apoptosis through mitochondrial apoptotic pathway. Since lysophosphatidic acid (LPA) levels are known to be significantly elevated after acute myocardial infarction LPA enhanced survival...
Introduction: There is growing evidence of research indicating that the gut microbiota involved in development sarcopenia. Nevertheless, there exists a notable deficiency comprehension concerning connection between irregularities intestinal microbiome and metabolic processes older individuals suffering from Methods: To analyze fecal samples obtained cohort 30 patients diagnosed with sarcopenia as well without sarcopenia, this study employed 16S rDNA sequencing liquid chromatography-mass...
Lysophosphatidic acid (LPA), as an endogenous lipid mediator, has been revealed to regulate many important biological and pathophysiological processes via specific G-protein-coupled receptors termed LPA1-5. We have previously shown that LPA antagonized the apoptosis of mesenchymal stem cells (MSCs) induced by hypoxia serum deprivation (hypoxia/SD), mimicking ischemic myocardium microenvironment. Whether same potentially beneficial effect on MSCs in vivo is unknown. Here we demonstrated...
<title>Abstract</title> Sepsis, a leading cause of hospital mortality, is characterized by substantial heterogeneity, hindering the development effective and interpretable prognostic stratification methods. To address this challenge, we developed an explainable model (SepsisFormer, transformer-based deep neural network with enhanced domain-adaptive generator) automated risk tool (SMART, scorecard consistent medical knowledge). In multicenter retrospective study 12,408 sepsis patients,...
Abstract Background Severe asthma is a chronic disease contributing to disproportionate morbidity and mortality. From the year of 2007, many genome-wide association studies (GWAS) have documented large number asthma-associated genetic variants related genes. Nevertheless, molecular mechanism these identified involved in or severe risk remains largely unknown. Methods In current study, we systematically integrated 3 independent expression quantitative trait loci (eQTL) data ( N = 1977)...
Type 2 diabetes mellitus (T2DM) is a global health issue that lacks effective treatments. Dysfunction and/or death of pancreatic β-cells (PBCs) are considered major cause T2DM. Therefore, elucidating the mechanisms underlying PBCs might be helpful to develop novel strategies treat Ferroptosis newly identified form cell has distinct features. However, knowledge regarding role ferroptosis in remains limited. In current study, we used high glucose (10 mM) (HG) levels induce PBC. We also...
Mesenchymal stem cells (MSCs) have exhibited great potential in the therapy of cardiovascular disease. However, application MSCs is hampered by apoptosis, which reduces number host cardiac microenvironment. Ulinastatin (UTI), a broad‑spectrum protease inhibitor that can be purified from human urine, has attracted attention for its protective effects through immunomodulatory and anti‑inflammatory properties. The present study aimed to evaluate UTI on serum deprivation‑induced apoptosis...
Abstract Introduction: Community-acquired (CA) carbapenem-susceptible Acinetobacter baumannii (CSAB) enterogenic sepsis is very rare but has a high mortality. Although CA A. bloodstream infections have been known to develop from respiratory tract, urinary and intravenous device-related infections, the gastrointestinal tract not yet reported. Patient concerns: A 73-year-old male with chief presentation of symptoms was initially diagnosed acute gastroenteritis showed poor clinical response...
Objective: To evaluate the influence of serum procalcitonin in diagnosis and treatment pulmonary infection patients with central nervous system injury. Methods: From October 2014 to February 2017, a retrospective study was performed. A total 1 852 were screened Department Intensive Care Unite, First Affiliated Hospital Sun Yat-sen University.Among them, 173 identified different kinds infection. Finally, 42 enrolled. The clinical data (CNS) injury collected. univariate multivariate regression...
To analyze the risk factors of renal replacement therapy (RRT) in acute kidney injury (AKI) patients after liver transplantation, and to investigate prognosis effect initial RRT treatment time.Clinical data 132 recipients undergoing organ donation for cardiac death (DCD) allograft orthotopic transplantation admitted Ningbo Medical Center Lihuili Hospital Eastern from July 2014 2018 was retrospectively analyzed. AKI defined staged by criteria Kidney Disease Improving Global Outcomes (KDIGO)...
To investigate the effects of simvastatin on atherosclerosis and central aortic pressure in ApoE-knockout (ApoE-/-) mice.Ten 5-week-old male ApoE-/- mice 5 C57 were fed with high-lipid diet for 3 weeks, then (WT group) (ApoE-/- given 1% carboxymethyl cellulose solution (8 ml·kg-1·d-1), another (ApoE-/-/S (50 mg·kg-1·d-1) by gavege weeks. The areas atherosclerotic lesion root, serum lipid levels examined.No plaques observed WT group. Compared group, significantly decreased area root (89...
Objective To investigate the accuracy of plasma DNA concentration in evaluating prognosis patients with sepsis.Methods One hundred and sixty sepsis were enrolled as group (group SE).Another 109 without hospitalized during same period served control C).The venous blood sample was taken on admission for determination by polymerase chain reaction,C reactive protein (CRP) ELISA.APACHE Ⅱ score SOFA evaluated at 24 h after admission.The 160 divided into two groups according to result...
Objective To analyze the risk factors of prognosis in elderly patients with septic shock ICU. Methods Clinical data 113 admitted ICU Ningbo Medical Center Lihuili Eastern Hospital from November 2015 to March 2019 were retrospectively analyzed. Among them, 40 died (death group) and 73 survived (survival within 28 d after diagnosis confirmed. The general information, underlying disease, laboratory findings invasive operations compared between two groups. Multivariate Logistic regression...