A5100676522- Neurological Disease Mechanisms and Treatments
- Ginkgo biloba and Cashew Applications
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Traditional Chinese Medicine Analysis
- Epigenetics and DNA Methylation
- Natural Compounds in Disease Treatment
- Pluripotent Stem Cells Research
- Drug Transport and Resistance Mechanisms
- Flavonoids in Medical Research
- Pharmacological Effects of Natural Compounds
- Ubiquitin and proteasome pathways
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- CRISPR and Genetic Engineering
- Ovarian function and disorders
- Parkinson's Disease Mechanisms and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Pregnancy and preeclampsia studies
- Pharmacogenetics and Drug Metabolism
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Studies
- Prenatal Screening and Diagnostics
- Reproductive Health and Technologies
- Chemokine receptors and signaling
Shandong University
2025
Zhongnan Hospital of Wuhan University
2019-2025
Wuhan University
2019-2025
The Fourth People's Hospital of Zibo City
2025
Nanjing University of Chinese Medicine
2011-2024
Baylor College of Medicine
2023-2024
Hubei Provincial Women and Children's Hospital
2024
Xuzhou Medical College
2024
Kanion Pharmaceutical (China)
2012-2021
Shanghai Clinical Research Center
2020
Abstract Endoplasmic reticulum (ER) stress induces the unfolded protein response (UPR), and prolonged ER leads to cell apoptosis. Despite increasing research in this area, underlying molecular mechanisms remain unclear. Here, we discover that upregulates UPR signaling pathway while downregulating E2F target gene expression inhibiting G2/M phase transition. Prolonged decreases mRNA levels of E2F2, which specifically regulates F-Box Protein 5(FBXO5), an F-box functions as inhibitor...
Abstract Ovarian cancer (OV) poses a significant challenge in clinical settings due to its difficulty early diagnosis and treatment resistance. FOXP4, belonging the FOXP subfamily, plays pivotal role various biological processes including cancer, cell cycle regulation, embryonic development. However, specific importance of FOXP4 OV have remained unclear. Our research showed that is highly expressed tissues, with elevated levels correlating poor prognosis. We further explored FOXP4’s function...
Abstract Endometriosis is linked to increased infertility and pregnancy complications due defective endometrial decidualization. We hypothesized that identification of altered signaling pathways during decidualization could identify the underlying cause complications. Our study reveals transforming growth factor β (TGFβ) are impaired in endometrium individuals with endometriosis, leading Through detailed transcriptomic analyses, we discovered abnormalities TGFβ key regulators, such as SMAD4,...
Intracellular calcium (Ca 2+ ) is a crucial signaling molecule involved in multiple cellular processes. However, the functional role of Ca terminal erythropoiesis remains unclear. Here, we uncovered dynamics intracellular levels during mouse erythroid development. By using ionophore ionomycin, found that low are required for expansion progenitors, whereas higher led to differentiation and proliferation early‐stage erythroblasts. were then gradually reduced, which nuclear condensation...
The primary aim was to investigate the relationship between serum growth differentiation factor-15 (GDF15) levels and non-motor symptom (NMS) in Parkinson's disease (PD) patients. secondary explore diagnostic value of GDF15 for specific NMS. A total 102 PD patients were enrolled this study, including 47 males 55 females. Doctors collected clinical demographic information detected level GDF15. Next, linear univariate multivariate regression analyses used assess correlation Receiver operating...
Abstract SEMA6A is a multifunctional transmembrane semaphorin protein that participates in various cellular processes, including axon guidance, cell migration, and cancer progression. However, the role of clear renal carcinoma (ccRCC) unclear. Based on high-throughput sequencing data, here we report novel target gene VHL - HIF 2α axis overexpressed ccRCC. Chromatin immunoprecipitation reporter assays revealed HIF-2α directly activated transcription hypoxic ccRCC cells. Wnt /β-catenin pathway...
Qi‐Wei‐Tong‐Bi oral liquid (QWTB), a famous Chinese medicine preparation composed of seven crude drugs has good therapeutic effect on rheumatoid arthritis and is widely used in China. However, its chemical composition quality control have not been comprehensively systematically investigated. In this study, high‐performance chromatography coupled with quadrupole time‐of‐flight mass spectrometry was employed for profiling. As result, 100 components were chemically characterized. Additionally,...
Atherosclerosis (AS), a chronic inflammatory vascular disease, is major cause of cardiovascular morbidity and mortality worldwide. Indigo naturalis (IN) medicinal edible plant with obvious pharmacological effects such as anti‐inflammation, improving blood circulation, antibacterial. However, its therapeutic efficacy mechanism action against AS remain unclear. This study aims to integrate network pharmacology, molecular docking, in vitro experimental evaluations uncover the active components...
Polycystic ovary syndrome (PCOS) is a complicated endocrinological and anovulatory disorder in women. Mice exposed to dihydrotestosterone (DHT) exhibit PCOS-like phenotype characterized by abnormal steroid hormone production ovulation dysfunction. The present investigation aims identify overlapping genes expressed PCOS patients mouse model induced DHT examine the function of key fatty acid synthase (FASN) We examined 5 datasets high-throughput mRNA transcription from Gene Expression Omnibus...
Human extended pluripotent stem cells (EPSCs), with bidirectional chimeric ability to contribute both embryonic and extraembryonic lineages, can be obtained maintained by converting conventional using chemicals. However, the transition system is based on inactivated mouse fibroblasts, underlying mechanism not clear. Here we report a Matrigel-based feeder-free method convert human induced into EPSCs demonstrate pluripotency in terms of molecular features, ability, transcriptome. We further...
Ethyl pyruvate (EP) is a simple aliphatic ester of the metabolic intermediate that has been demonstrated to be potent anti-inflammatory agent in variety vivo and vitro model systems. However, protective effects mechanisms underlying actions EP against endothelial cell (EC) inflammatory injury are not fully understood. Previous studies have confirmed endoplasmic reticulum stress (ERS) plays an important role regulating pathological process EC inflammation. In this study, our aim was explore...