A5101405415- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Gastrointestinal Tumor Research and Treatment
- Acute Myeloid Leukemia Research
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Galectins and Cancer Biology
- Gastric Cancer Management and Outcomes
- RNA Research and Splicing
- Lipid metabolism and biosynthesis
- Erythrocyte Function and Pathophysiology
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Oral microbiology and periodontitis research
- Peptidase Inhibition and Analysis
- Hemoglobinopathies and Related Disorders
- Metabolism, Diabetes, and Cancer
- RNA modifications and cancer
Shandong University
2024-2025
The University of Texas Health Science Center at Houston
2025
Supernus Pharmaceuticals (United States)
2025
Zimmer Biomet (United States)
2025
Zhongshan Hospital of Xiamen University
2025
Fudan University
2025
Air Force Medical University
2024
The First Affiliated Hospital, Sun Yat-sen University
2023
Sun Yat-sen University
2023
Zhejiang Cancer Hospital
2022
Imatinib is the first-line targeted therapy for gastrointestinal stromal tumor (GIST), but resistance frequently occurs during treatment, limiting its efficacy and clinical application. We performed high-throughput sequencing of tissue specimens from imatinib-resistant GIST patients, identified significantly high expression polymeric immunoglobulin receptor (PIGR) in cell lines. Further investigation revealed that PIGR binds specifically to LINC00870. The findings vitro functional...
Intracellular calcium (Ca 2+ ) is a crucial signaling molecule involved in multiple cellular processes. However, the functional role of Ca terminal erythropoiesis remains unclear. Here, we uncovered dynamics intracellular levels during mouse erythroid development. By using ionophore ionomycin, found that low are required for expansion progenitors, whereas higher led to differentiation and proliferation early‐stage erythroblasts. were then gradually reduced, which nuclear condensation...
The prognosis for cervical cancer (CC) patients with lymph node metastasis (LNM) is extremely poor. Lipid droplets (LDs) have a pivotal role in promoting tumor metastasis. crosstalk mechanism between LDs and LNM modulated CC remains largely unknown.This study aimed to construct miRNA-dependent progonostic model investigate whether miR-532-5p has biological impact on by regualting accumulation.LASSO-Cox regression was applied establish prognostic prediction model. had the lowest P-value RNA...
Lymph node (LN) metastasis is one of the most malignant clinical features in patients with cervical cancer (CCa). Understanding mechanism lymph will provide treatment strategies for CCa. Circular RNAs (circRNA) play a critical role development human cancers. However, and circRNAs remain largely unknown. Here, it reported that loss expression circRNA circVPRBP was closely associated LN poor survival CCa patients. In vitro vivo assays showed overexpression notably inhibited lymphangiogenesis...
ABSTRACT Targeted cancer therapies aim to effectively treat patients with specific biomarker profiles. Nevertheless, these may not always precisely hit their intended targets, leading uncertainty about the subset of who will benefit. To address this uncertainty, identification sensitive patient subsets in clinical trials becomes crucial. Our proposed phase IIB/III trial design seeks pinpoint a signature precision, ensuring accurate respond treatment. This approach allows for selective...
This study aimed to investigate the molecular mechanisms of periodontitis and identify key immune‐related biomarkers using machine learning Mendelian randomization (MR). Differentially expressed gene (DEG) analysis was performed on datasets GSE16134 GSE10334 from Gene Expression Omnibus (GEO) database, followed by weighted co‐expression network (WGCNA) relevant modules. Various algorithms were utilized construct predictive models, highlighting core genes, while MR assessed causal...
Gastric cancer (GC) is one of the most common malignant tumors worldwide and has a poor prognosis. Previous studies have confirmed differential histone deacetylase 5 (HDAC5) expression in various tumors. HDAC5 also associated with prognosis plays role cell proliferation, invasion, metastasis, as well tumor immune microenvironment (TIME). However, GC not understood. The aims study were to investigate correlates TIME GC.A total 355 tissues 300 matched paracancerous collected from patients who...
Abstract In recent years, breast cancer attracts more and attention because of its high incidence. To explore the molecular functions mechanisms, we performed RNA sequencing on tumor tissues their paired normal from three patients. By differential expression analysis, found 3764 differentially expressed (DE) mRNAs, 5416 DE lncRNAs, 148 circRNAs. Enrichment analysis suggested that lncRNAs circRNAs were enriched in mitochondria nucleus, which indicated they may participate vital metabolism...