A5100765501- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Multiple Sclerosis Research Studies
- Atomic and Subatomic Physics Research
- Medical Imaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound Imaging and Elastography
- NMR spectroscopy and applications
- RNA regulation and disease
- Medical Image Segmentation Techniques
- Advanced X-ray and CT Imaging
- Photoacoustic and Ultrasonic Imaging
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- AI in cancer detection
- Electron Spin Resonance Studies
- Genetic Neurodegenerative Diseases
- Lanthanide and Transition Metal Complexes
University of Electronic Science and Technology of China
2024-2025
Cornell University
2016-2025
Renmin University of China
2023-2025
Weill Cornell Medicine
2016-2025
Peking University
2023-2025
Peking University Third Hospital
2023-2025
The First People's Hospital of Guiyang
2025
Second Affiliated Hospital of Fujian Medical University
2022-2025
Fujian Medical University
2022-2025
Tongren Hospital
2025
Abstract For optimal image quality in susceptibility‐weighted imaging and accurate quantification of susceptibility, it is necessary to isolate the local field generated by magnetic sources (such as iron) from background that arises imperfect shimming variations susceptibility surrounding tissues (including air). Previous removal techniques have limited effectiveness depending on accuracy model assumptions or information input. In this article, we report an observation for a dipole outside...
To test the hypothesis that respiration effects in three-dimensional (3D) coronary magnetic resonance (MR) imaging can be reduced with navigator-echo-based gating or triggering according to superior-inferior position of diaphragm.Real-time respiratory and (breath hold feedback) were implemented navigator echoes a magnetization-prepared, segmented, 3D sequence. The two techniques first tested motion phantom. An protocol compared real-time respiratory-gated acquisition, respiratory-triggered...
Abstract Magnetic susceptibility varies among brain structures and provides insights into the chemical molecular composition of tissues. However, determination an arbitrary distribution from measured MR signal phase is a challenging, ill‐conditioned inverse problem. Although previous method named calculation through multiple orientation sampling (COSMOS) has solved this problem both theoretically experimentally using angle acquisitions, it often impractical to carry out on human subjects....
Abstract Quantitative susceptibility mapping (QSM) opens the door for measuring tissue magnetic properties that may be important biomarkers, and QSM is becoming an increasingly active area of scientific clinical investigations. In practical applications, there are sources errors including noise, phase unwrapping failures, signal model inaccuracy. To improve robustness quality, we propose a nonlinear data fidelity term frequency map estimation dipole inversion to reduce noise effects method...
Purpose To apply quantitative susceptibility mapping (QSM) in the basal ganglia of patients with multiple sclerosis (MS) and relate findings to R2* regard sensitivity for clinical morphologic measures disease severity. Materials Methods The local ethics committee approved this study, all subjects gave written informed consent. Sixty-eight (26 clinically isolated syndrome, 42 relapsing-remitting MS) 23 control underwent 3-T magnetic resonance (MR) imaging. Susceptibility maps were...
To compare gradient-echo (GRE) phase magnetic resonance (MR) imaging and quantitative susceptibility mapping (QSM) in the detection of intracranial calcifications hemorrhages.This retrospective study was approved by institutional review board. Thirty-eight patients (24 male, 14 female; mean age, 33 years ± 16 [standard deviation]) with and/or hemorrhages diagnosed on basis computed tomography (CT), MR (interval between examinations, 1.78 days 1.31), clinical information were selected. GRE...
Purpose Within multiple sclerosis (MS) lesions iron is present in chronically activated microglia. Thus, detection with MRI might provide a biomarker for chronic inflammation within lesions. Here, we examine contributions of and myelin to magnetic susceptibility on quantitative mapping (QSM). Methods Fixed MS brain tissue was assessed including gradient echo data, which processed generate field (phase), R2* QSM. Five were sectioned evaluated by immunohistochemistry presence myelin,...
Purpose To assess multiple sclerosis (MS) lesions at various ages by using quantitative susceptibility mapping (QSM) and conventional magnetic resonance (MR) imaging. Materials Methods Retrospectively selected were 32 clinically confirmed MS patients (nine men 23 women; 39.3 years ± 10.9) who underwent two MR examinations (interval, 0.43 0.16) with three-dimensional gradient-echo sequence from August 2011 to 2012. estimate the of lesions, performed 0.3–10.6 before study studied....
Chronic active multiple sclerosis lesions, characterized by a hyperintense rim of iron-enriched, activated microglia and macrophages, have been linked to greater tissue damage. Post-mortem studies determined that chronic lesions are primarily related the later stages sclerosis; however, occurrence these their relationship earlier disease may be greatly underestimated. Detection across patient spectrum requires validated imaging tool accurately identify with persistent inflammation....
Purpose To develop a quantitative susceptibility mapping (QSM) method with consistent zero reference using minimal variation in cerebrospinal fluid (CSF) susceptibility. Theory and Methods The ventricular CSF was automatically segmented on the map. An L 2 ‐regularization used to enforce homogeneity within region, averaged as reference. This regularization for added model prior QSM (morphology enabled dipole inversion [MEDI]). Therefore, proposed referred MEDI+0 compared MEDI numerical...
Abstract This article provides recommendations for implementing QSM clinical brain research. It is a consensus of the International Society Magnetic Resonance in Medicine, Electro‐Magnetic Tissue Properties Study Group. While technical development continues to advance rapidly, current methods have been demonstrated be repeatable and reproducible generating quantitative tissue magnetic susceptibility maps brain. However, many approaches available generated need neuroimaging community...
Quantitative susceptibility mapping (QSM) can study the values of brain tissue which allows for noninvasive examination local iron levels in both normal and pathological conditions. Our compares deposition gray matter (GM) nuclei between cerebral small vessel disease (CSVD) patients healthy controls (HCs), exploring factors that affect cognitive function. A total 321 subjects were enrolled this study. All had including Stroop color word test (SCWT) MRI multiecho gradient echo (mGRE)...
Magnetic susceptibility is an important physical property of tissues, and can be used as a contrast mechanism in magnetic resonance imaging (MRI). Recently, targeting agents by conjugation with signaling molecules labeling stem cells have become feasible. These are strongly paramagnetic, the ability to quantify could allow accurate measurement cell localization. Presented here technique estimate arbitrary distributions solving ill-posed inversion problem from field maps obtained MRI scanner....
Abstract A single “orbital” navigator echo, that has a circular k ‐space trajectory, is used to simultaneously measure in‐plane rotational and multi‐axis translational global motion. Rotation determined from the shift in magnitude profile of echo with respect reference echo. Displacements are calculated phase difference between current Phantom studies show this technique can accurately rotation translations. Preliminary results adaptive motion correction on phantom human subjects indicate...
Parkinson's disease (PD) is marked pathologically by dopamine neuron loss and iron overload in the substantia nigra pars compacta. Midbrain content reported to be increased PD based on magnetic resonance imaging (MRI) R2* changes. Because quantitative susceptibility mapping a novel MRI approach measure content, we compared it with for assessing midbrain changes PD.Quantitative maps were obtained from 47 patients healthy controls. values analyzed using both voxel-based region-of-interest...
<h3>BACKGROUND AND PURPOSE:</h3> Quantitative susceptibility mapping allows overcoming several nonlocal restrictions of susceptibility-weighted and phase imaging enables quantification magnetic susceptibility. We compared the diagnostic accuracy quantitative R2* (1/T2*) to discriminate between patients with Parkinson disease controls. <h3>MATERIALS METHODS:</h3> For 21 age- sex-matched controls, 2 radiologists measured values in 6 brain structures (the thalamus, putamen, caudate nucleus,...
Purpose To quantitatively map cerebral metabolic rate of oxygen ( ) and extraction fraction in human brains using quantitative susceptibility mapping (QSM) arterial spin labeling‐measured blood flow (CBF) before after caffeine vasoconstriction. Methods Using the multiecho, three‐dimensional gradient echo sequence an oral bolus 200 mg caffeine, whole brain were mapped at 3‐mm isotropic resolution on 13 healthy subjects. The QSM‐based was compared with ‐based to analyze regional consistency...
To assess quantitative susceptibility mapping (QSM) in the depiction of subthalamic nucleus (STN) by using 3-T magnetic resonance (MR) imaging.This study was HIPAA compliant and institutional review board approved. Ten healthy subjects (five men, five women; mean age, 24 years ± 3 [standard deviation]; age range, 21-33 years) eight patients with Parkinson disease three 57 14; 25-69 who were referred neurologists for preoperative navigation MR imaging prior to deep brain stimulator placement...
Purpose To investigate systematic errors in traditional quantitative susceptibility mapping (QSM) where background field removal and local inversion (LFI) are performed sequentially, to develop a total (TFI) QSM method reduce these errors, improve quality the presence of large differences. Theory Methods The proposed TFI is single optimization problem which simultaneously estimates fields, preventing error propagation from QSM. increase computational speed, new preconditioner introduced...
Purpose Venous blood oxygen saturation is an indicator of brain consumption and can be measured directly from quantitative susceptibility mapping (QSM) by deconvolving the MR phase signal. However, accurate estimation may affected flow induced in presence imaging gradient inhomogeneous field gradient. The purpose this study to correct error QSM for improved venous oxygenation quantification. Methods Flow compensation proposed using a fully compensated multi‐echo echo sequence data...
Determining the susceptibility distribution from magnetic field measured in a resonance (MR) scanner is an ill-posed inverse problem, because of presence zeroes convolution kernel forward problem. An algorithm called morphology enabled dipole inversion (MEDI), which incorporates spatial prior information, has been proposed to generate quantitative map (QSM). The accuracy QSM can be validated experimentally. However, there not yet rigorous mathematical demonstration for general regularized...
The objective of this study was to evaluate susceptibility changes caused by iron accumulation in cognitive normal (CN) elderly, those with amnestic mild impairment (aMCI), and early state AD, compare the findings gray matter volume (GMV) neuronal loss. participants included 19 elderly CN, aMCI, AD subjects. voxel-based quantitative map (QSM) GMV brain were calculated differences insides compared among three groups. QSM data GMVs groups investigated region interest (ROI)-based comparisons...