A5037597876- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Stress Responses and Cortisol
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Tryptophan and brain disorders
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Mental Health Research Topics
- Cardiac Imaging and Diagnostics
- Parkinson's Disease Mechanisms and Treatments
- Pancreatic and Hepatic Oncology Research
- Neurogenesis and neuroplasticity mechanisms
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Axon Guidance and Neuronal Signaling
- Treatment of Major Depression
- Phosphodiesterase function and regulation
- IgG4-Related and Inflammatory Diseases
- Atomic and Subatomic Physics Research
- Olfactory and Sensory Function Studies
- Transcranial Magnetic Stimulation Studies
The University of Tokyo
2024
Hirosaki University
2022
University of Occupational and Environmental Health Japan
2014-2022
University of California, Los Angeles
2020-2021
University of California System
2021
University of the Ryukyus
2008
<h3>BACKGROUND AND PURPOSE:</h3> Quantitative susceptibility mapping allows overcoming several nonlocal restrictions of susceptibility-weighted and phase imaging enables quantification magnetic susceptibility. We compared the diagnostic accuracy quantitative R2* (1/T2*) to discriminate between patients with Parkinson disease controls. <h3>MATERIALS METHODS:</h3> For 21 age- sex-matched controls, 2 radiologists measured values in 6 brain structures (the thalamus, putamen, caudate nucleus,...
There is a growing body of evidence to support the involvement proinflammatory cytokines in pathophysiology depression; however, no previous studies have examined relationship between and brain morphology patients with major depressive disorder (MDD). We therefore evaluated serum cytokine levels cortical thinning during first episode drug-naïve MDD. measured (IL-1β, IL-6, IFN-γ, TNFα), whole-brain thickness hippocampal subfield volumes on magnetic resonance imaging (MRI) using surface-based...
Recently, accumulated evidence has indicated a role of inflammation in the pathogenesis major depressive disorder (MDD). Therefore, we evaluated relationship between white matter integrity and serum cytokine levels during first episode drug-naive MDD patients, using tract-based spatial statistics (TBSS) method. A total 35 patients with healthy subjects (HS) underwent diffusion tensor imaging, an analysis was conducted TBSS. We measured (interleukin [IL]-1β, IL-6, interferon-γ, tumor necrosis...
Higher daytime cortisol levels because of a hyperactive hypothalamic-pituitary-adrenal axis have been reported in patients with major depressive disorder (MDD). The elevated glucocorticoids inhibit the proliferation oligodendrocytes that are responsible for myelinating axons white matter fibre tracts.To evaluate relationship between integrity and serum during first episode drug-naive MDD (MDD group) using tract-based spatial statistics (TBSS) method.The group (n = 29) healthy control 47)...
In the present study, we aimed to investigate difference in white matter between smokers and nonsmokers. addition, examined relationships integrity nicotine dependence parameters smoking subjects. Nineteen male were enrolled this study. Eighteen age-matched non-smokers with no current or past psychiatric history included as controls. Diffusion tensor imaging scans performed, analysis was conducted using a tract-based special statistics approach. Compared nonsmokers, exhibited significant...
Objective In major depressive disorder (MDD) patients, higher morning cortisol levels due to a hyperactive hypothalamic–pituitary–adrenal (HPA) axis have been reported. The aim of the present study was evaluate relationship between cortical thinning and serum during first episode in drug-naïve MDD patients using an automated surface-based morphometry (SBM) method. Methods institutional review board approved this prospective study. MR imaging data were obtained 3T scanner by three-dimensional...
A genome-wide association study using megadata identified 17 single-nucleotide polymorphisms (SNPs) in candidate genes for major depressive disorder (MDD). These MDD susceptibility may affect white matter (WM) integrity. This aimed to investigate the relationship between WM alterations and SNPs first episode of drug-naive patients a tract-based spatial statistics (TBSS) method.Thirty-five with 47 age-and sex-matched healthy subjects underwent diffusion tensor imaging scans genotyping. The...
Abstract Purpose To develop a support vector machine (SVM) classifier using CT texture-based analysis in differentiating focal-type autoimmune pancreatitis (AIP) and pancreatic duct carcinoma (PD), to assess the radiologists’ diagnostic performance with or without SVM. Materials methods This retrospective study included 50 patients (20 AIP 30 PD) who underwent dynamic contrast-enhanced CT. Sixty-two features were extracted from 2D images of arterial portal phase CTs. We conducted data...
Abstract Understanding the neural correlates of neurotic brain is important because neuroticism a risk factor for development psychopathology. We examined correlation between structural networks and based on NEO Five-Factor Inventory (NEO-FFI) scores. Fifty-one healthy participants (female, n = 18; male, 33; mean age, 38.5 ± 11.7 years) underwent NEO-FFI test magnetic resonance imaging (MRI), including diffusion tensor 3D T1WI. Using MRI data, each participant, we constructed whole-brain...
Background Earlier studies implicated norepinephrine transporter (NET) gene (SLC6A2) polymorphisms in the etiology of major depressive disorder (MDD). Recently, two single nucleotide SLC6A2 polymorphisms, G1287A exon 9 and T-182C promoter region, were found to be associated with MDD different populations. We investigated relationship between brain volume these patients. Methods obtained 3D high-resolution T1-weighted images 30 first-episode patients 48 age- sex-matched healthy subjects (HS)....
Abstract: We investigated the association between Val158Met polymorphism of catechol-O-methyltransferase ( COMT ) gene, Val66Met brain-derived neurotrophic factor BDNF and white matter changes in patients with major depressive disorder (MDD) healthy subjects using diffusion tensor imaging (DTI). studied 30 MDD (17 males 13 females, mean age ± standard deviation [SD] =44±12 years) sex- age-matched controls aged 44±13 years). Using DTI analysis a tract-based spatial statistics (TBSS) approach,...
Our purpose was to identify correlations between <sup>18</sup>F-fluorodihydroxyphenylalanine (<sup>18</sup>F-FDOPA) uptake and physiologic MRI, including relative cerebral blood volume (rCBV) apparent diffusion coefficient (ADC), in gliomas with different molecular subtypes evaluate their prognostic values. <b>Methods:</b> Sixty-eight treatment-naïve glioma patients who underwent <sup>18</sup>F-FDOPA PET MRI were retrospectively selected (36 isocitrate dehydrogenase wild-type...
Recently, a genome-wide association study successfully identified genetic variants associated with major depressive disorder (MDD). The 17 independent single-nucleotide polymorphisms (SNPs) significantly diagnosis of MDD. These SNPs were predicted to be enriched in genes that are expressed the central nervous system and function transcriptional regulation neurodevelopment. aimed investigate associations between brain morphometry using magnetic resonance imaging (MRI) drug-naïve patients MDD...
Purpose: Compared with healthy subjects (HS), patients major depressive disorder (MDD) exhibit volume differences that affect the changes in several areas such as limbic, cortical, subcortical, and white matter. Catechol-O-methyltransferase (COMT) is a methylation enzyme catalyzes endogenous catecholamines. The Val158Met polymorphism of COMT has been reported to dopamine (DA) levels, which plays an important role psychiatric diseases. However, relationships among both DA genotype, brain...
In multiple sclerosis (MS), a juxtacortical lesion at the border between gray matter (GM) and subcortical white (WM) may often involve GM. A recently developed, phase-weighted magnetic resonance imaging (MRI) technique "phase difference enhanced (PADRE)" can delineate GM WM clearly due to in myelin concentration. We evaluated whether PADRE is useful for detection of involvement MS lesions.One neuroradiologist reviewed conventional MRI 13 patients selected 48 lesions. At first reading session...