A5000745495- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Polyomavirus and related diseases
- Immunotherapy and Immune Responses
- RNA regulation and disease
- Neurogenesis and neuroplasticity mechanisms
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Immune Response and Inflammation
- Advanced Neuroimaging Techniques and Applications
- Cerebral Venous Sinus Thrombosis
- Long-Term Effects of COVID-19
- Platelet Disorders and Treatments
- T-cell and B-cell Immunology
- Sinusitis and nasal conditions
- Ultrasound and Hyperthermia Applications
- Neurological Complications and Syndromes
- Migraine and Headache Studies
- Autoimmune Neurological Disorders and Treatments
- Herpesvirus Infections and Treatments
- Olfactory and Sensory Function Studies
- Immune cells in cancer
- Autoimmune Bullous Skin Diseases
- Ocular Infections and Treatments
Weill Cornell Medicine
2016-2025
Cornell University
2016-2025
Cornell College
2025
Multiple Sclerosis Center Of Northeastern New York
2020
MIND Research Institute
2016-2019
Presbyterian Hospital
2015-2018
New York Audio Productions (United States)
2016
New York Hospital Queens
2016
NewYork–Presbyterian Hospital
2016
Rockefeller University
2009-2015
Chronic active multiple sclerosis lesions, characterized by a hyperintense rim of iron-enriched, activated microglia and macrophages, have been linked to greater tissue damage. Post-mortem studies determined that chronic lesions are primarily related the later stages sclerosis; however, occurrence these their relationship earlier disease may be greatly underestimated. Detection across patient spectrum requires validated imaging tool accurately identify with persistent inflammation....
Importance Biomarkers distinguishing nonrelapsing progressive disease biology from relapsing in multiple sclerosis (MS) are lacking. Cerebrospinal fluid (CSF) is an accessible that most closely reflects central nervous system biology. Objective To identify CSF biological measures associated with MS pathobiology. Design, Setting, and Participants This cohort study assessed data 2 prospective cohorts: a test provided serial CSF, clinical, imaging assessments multicenter of patients (RMS) or...
Abstract The CD11c enhanced yellow fluorescent protein (EYFP) transgenic mouse was constructed to identify dendritic cells in the periphery (Lindquist et al. [ 2004 ] Nat. Immunol. 5:1243–1250). In this study, we used characterize within CNS. Our anatomic results showed discrete populations of EYFP + brain (EYFP bDC) that colocalized with a small fraction microglia immunoreactive for Mac‐1, Iba‐1, CD45, and F4/80 but not NeuN, Dcx, NG2 proteoglycan, or GFAP. bDC, isolated by activated cell...
Abstract Background Inflammation in chronic active lesions occurs behind a closed blood–brain barrier and cannot be detected with MRI. Activated microglia are highly enriched for iron can visualized quantitative susceptibility mapping (QSM), an MRI technique used to delineate iron. Objective To characterize the histopathological correlates of different QSM hyperintensity patterns MS lesions. Methods brain slabs were imaged QSM, processed histology. Immunolabeled cells quantified lesion rim,...
Abstract Quantitative susceptibility mapping (QSM), an imaging technique sensitive to brain iron, has been used detect paramagnetic rims of iron-laden active microglia and macrophages in a subset multiple sclerosis (MS) lesions, known as rim+ that are consistent with chronic lesions. Because the potential impact lesions on disease progression tissue damage, investigating their influence disability neurodegeneration is critical establish these course. This study aimed explore relationship...
A small proportion of multiple sclerosis (MS) patients develop new disease activity soon after starting anti-CD20 therapy. This does not recur with further dosing, possibly reflecting deeper depletion CD20-expressing cells repeat infusions. We assessed cellular immune profiles and their association transient following initiation as a window into relapsing biology. Peripheral blood mononuclear from independent discovery validation cohorts MS initiating ocrelizumab were for phenotypic...
Multiple Sclerosis (MS) is a complex disease of the CNS thought to require an environmental trigger. Gut dysbiosis common in MS, but specifically causative species are unknown. To address this knowledge gap, we used sensitive and quantitative PCR detection show that people with MS were more likely harbor greater abundance epsilon toxin (ETX)-producing strains C. perfringens within their gut microbiomes compared healthy controls (HC). patient-derived isolates produced functional ETX had...
Dendritic cells (DC) are the professional antigen presenting (APC) that bridge innate and adaptive immune system. Previously, in a CD11c/EYFP transgenic mouse developed to study DC functions, we anatomically mapped phenotypically characterized discrete population of EYFP + within microglia termed brain dendritic (bDC). In this study, advanced our knowledge function these its chimeras, using acute stimuli stereotaxically inoculated IFNγ or IL-4 into CNS. The administration increased number...
To compare quantitative susceptibility mapping (QSM) and high-pass-filtered (HPF) phase imaging for (1) identifying chronic active rim lesions with more myelin damage (2) distinguishing patients increased clinical disability in multiple sclerosis.Eighty were scanned QSM paramagnetic detection Fast Acquisition Spiral Trajectory T2prep water fraction (MWF). Chronic classified based on the presence/absence of HPF images. A lesion-level linear mixed-effects model MWF as outcome was used to among...
Abstract Prediction of disease progression is challenging in multiple sclerosis as the sequence lesion development and retention inflammation within a subset chronic lesions heterogeneous among patients. We investigated lesion-related regional structural disconnectivity across spectrum disability cognitive impairment sclerosis. In full cohort 482 patients (age: 41.83 ± 11.63 years, 71.57% females), Expanded Disability Status Scale was used to classify into (i) no or mild (Expanded <3)...
Abstract Background In people with multiple sclerosis (pwMS), lesions a hyperintense rim (rim+) on Quantitative Susceptibility Mapping (QSM) have been shown to greater myelin damage compared rim‐ lesions, but their association disability has not yet investigated. Furthermore, how QSM rim+ and differentially impact through disruptions structural connectivity explored. We test the hypothesis that disconnectivity due is more predictive of lesions. Methods Ninety‐six pwMS were included in our...
Abstract Objective To explore whether the inflammatory activity is higher in white matter (WM) tracts disrupted by paramagnetic rim lesions (PRLs) and if inflammation PRL-disrupted WM associated with disability people multiple sclerosis (MS). Methods Forty-four MS patients 16 healthy controls were included. 18 kDa-translocator protein positron emission tomography (TSPO-PET) 11 C-PK11195 radioligand was used to measure neuroinflammatory activity. The Network Modification Tool identify PRLs...
COVID-19 affects a wide spectrum of organ systems. We report 52-year-old man with hypertension and newly diagnosed diabetes mellitus who presented hypoxic respiratory failure due to developed severe brachial plexopathy. He was not treated prone positioning therapy. Associated the flaccid, painfully numb left upper extremity livedoid, purpuric rash on his hand forearm consistent COVID-19-induced microangiopathy. Neuroimaging electrophysiological data were near diffuse plexitis selective...
Black American (BA) multiple sclerosis (MS) patients experience greater disability compared to White (WA) patients. Here, we investigated the role of paramagnetic rim lesions (PRLs), a subset chronic active lesions, on race-related in MS.
Alemtuzumab is a monoclonal antibody approved for relapsing-remitting multiple sclerosis (RRMS). Although Immune thrombocytopenia (ITP) has been reported as secondary autoimmune phenomenon following alemtuzumab infusion, immediate during the infusion not reported.We report transient, reversible, self-limiting acute-onset first course with alemtuzumab.In total, 3 of 22 paitents developed mild self-limited bruising associated drop in platelet count from their baseline intial 5-day alemtuzumab....
To determine the influence of self-reported Black African and Latin American identity on peripheral blood antibody-secreting cell (ASC) frequency in context relapsing-remitting MS.In this cross-sectional study, we recruited 74 subjects with MS 24 age-, ethno-ancestral identity-matched healthy donors (HDs) to provide study samples. Subjects were either off therapy at time draw or monthly natalizumab infusions. Using flow cytometry, assessed mononuclear cells for B-cell subsets.When stratified...