A5054532448- Antifungal resistance and susceptibility
- Microbial Natural Products and Biosynthesis
- Fungal and yeast genetics research
- Mycotoxins in Agriculture and Food
- Fungal Infections and Studies
- Fungal Biology and Applications
- Plant Pathogens and Fungal Diseases
- Peptidase Inhibition and Analysis
- Plant-Microbe Interactions and Immunity
- Genomics and Phylogenetic Studies
- Bacterial Genetics and Biotechnology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Microbial Metabolic Engineering and Bioproduction
- Plant biochemistry and biosynthesis
- Redox biology and oxidative stress
- Microbial Metabolism and Applications
- Asthma and respiratory diseases
- Polysaccharides and Plant Cell Walls
- Mycorrhizal Fungi and Plant Interactions
- Infectious Diseases and Mycology
- Bioinformatics and Genomic Networks
- Chemical Synthesis and Analysis
- Bacterial biofilms and quorum sensing
- RNA and protein synthesis mechanisms
- Protist diversity and phylogeny
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)
2016-2025
Czech Academy of Sciences, Institute of Microbiology
2007-2025
Friedrich Schiller University Jena
2015-2024
Schiller (France)
2024
King Saud bin Abdulaziz University for Health Sciences
2024
Leibniz Association
2005-2023
Innsbruck Medical University
2009-2018
Schiller International University
2007-2015
Leibniz Institute for Neurobiology
2013
In-Q-Tel
2011
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded biosynthetic gene clusters. Information about these clusters, is currently dispersed throughout the literature, making it difficult exploit. To facilitate consistent systematic deposition retrieval data on we propose Minimum a Biosynthetic Gene cluster (MIBiG) standard.
Fungi produce numerous low molecular weight molecules endowed with a multitude of biological activities. However, mining the full-genome sequences fungi indicates that their potential to secondary metabolites is greatly underestimated. Because most biosynthesis gene clusters are silent under laboratory conditions, one major challenges understand physiological conditions which these genes activated. Thus, we cocultivated important model fungus Aspergillus nidulans collection 58 soil-dwelling...
Aspergillus fumigatus is a fungal pathogen causing severe infections in immunocompromised patients. For clearance of inhaled conidia, an efficient response the innate immune system required. Macrophages represent first line defence and ingest kill conidia. C-type lectins family receptors, which recognize pathogen-specific carbohydrates. One them beta1-3 glucan, major component cell wall. Here we provide evidence that glucan plays important role for elimination A. Laminarin, soluble...
Aspergillus fumigatus is the most important airborne fungal pathogen causing life-threatening infections in immunocompromised patients. Macrophages and neutrophils are known to kill conidia, whereas hyphae killed mainly by neutrophils. Since too large be engulfed, possess an array of extracellular killing mechanisms including formation neutrophil traps (NETs) consisting nuclear DNA decorated with fungicidal proteins. However, until now NET response A. has only been demonstrated vitro,...
ABSTRACT To increase the frequency of homologous recombination, we inactivated KU80 homologue in Aspergillus fumigatus (named akuB ). Homologous integration reached about 80% for both calcineurin A ( calA ) and polyketide synthase pksP (alb1 genes mutant to 3 5%, respectively, when using a wild-type A. strain. Deletion had no influence on pathogenicity low-dose murine infection model.
Microorganisms form diverse multispecies communities in various ecosystems. The high abundance of fungal and bacterial species these consortia results specific communication between the microorganisms. A key role this is played by secondary metabolites (SMs), which are also called natural products. Recently, it was shown that interspecies 'talk' microorganisms represents a physiological trigger to activate silent gene clusters leading formation novel SMs involved species. This review focuses...
Sequence analyses of fungal genomes have revealed that the potential fungi to produce secondary metabolites is greatly underestimated. In fact, most gene clusters coding for biosynthesis antibiotics, toxins, or pigments are silent under standard laboratory conditions. Hence, it one major challenges in microbiology uncover mechanisms required pathway activation. Recently, we discovered intimate physical interaction important model fungus Aspergillus nidulans with soil-dwelling bacterium...
Iron is essential for a wide range of cellular processes. Here we show that the bZIP-type regulator HapX indispensable transcriptional remodeling required adaption to iron starvation in opportunistic fungal pathogen Aspergillus fumigatus. represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster heme biosynthesis. In agreement with impact on mitochondrial HapX-deficiency decreases resistance tetracycline...
ABSTRACT The major cause of athlete’s foot is Trichophyton rubrum , a dermatophyte or fungal pathogen human skin. To facilitate molecular analyses the dermatophytes, we sequenced T. and four related species, tonsurans equinum Microsporum canis gypseum . These species differ in host range, mating, disease progression. genomes are highly colinear yet contain gene family expansions not found other human-associated fungi. Dermatophyte enriched for families containing LysM domain, which binds...
The opportunistic human pathogenic fungus Aspergillus fumigatus produces at least two types of melanin, namely pyomelanin and dihydroxynaphthalene (DHN) melanin. Pyomelanin is produced during tyrosine catabolism via accumulation homogentisic acid. Although protects the against reactive oxygen species acts as a defense compound in response to cell wall stress, mutants deficient for biosynthesis do not differ virulence when tested murine infection model invasive pulmonary aspergillosis. DHN...
Aspergillus fumigatus, the most common airborne fungal pathogen of humans, employs two high-affinity iron uptake systems: mediated by extracellular siderophore triacetylfusarinine C and reductive assimilation. Furthermore, A. fumigatus utilizes intracellular siderophores, ferricrocin hydroxyferricrocin, to store iron. Siderophore biosynthesis, which is essential for virulence, repressed Here we show that this control GATA factor SreA. During iron-replete conditions, SreA deficiency partially...
Aspergillus fumigatus is an important pathogen of immunocompromised hosts, causing pneumonia and invasive disseminated disease with high mortality. The factors contributing to the predominance A. as opportunistic are largely unknown. Since survival conidia in host a prerequisite for establishing disease, we have been attempting identify which associated and, simultaneously, infection. Therefore, mutant strain (white [W]) lacking conidial pigmentation was isolated. Scanning electron...