A5057802810- Cystic Fibrosis Research Advances
- Antifungal resistance and susceptibility
- Infectious Diseases and Mycology
- Asthma and respiratory diseases
- Mycobacterium research and diagnosis
- Immunodeficiency and Autoimmune Disorders
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Fungal Infections and Studies
- Neonatal Respiratory Health Research
- Nosocomial Infections in ICU
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autoimmune and Inflammatory Disorders Research
- Tracheal and airway disorders
- Antibiotic Resistance in Bacteria
- Drug-Induced Adverse Reactions
- Insects and Parasite Interactions
- vaccines and immunoinformatics approaches
- Dysphagia Assessment and Management
- Nematode management and characterization studies
- Inhalation and Respiratory Drug Delivery
Charité - Universitätsmedizin Berlin
2019-2023
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023
Humboldt-Universität zu Berlin
2019
Freie Universität Berlin
2019
BACKGROUNDThe fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). Th cells orchestrate immune responses against fungi, but the types A. fumigatus-specific pwCF and their contribution to protective immunity or inflammation remain poorly characterized.METHODSWe used antigen-reactive T cell enrichment (ARTE) investigate fungus-reactive peripheral blood healthy controls.RESULTSWe show that clonally expanded, high-avidity effector cells,...
Mycobacterium (M.) abscessus infections in Cystic Fibrosis (CF) patients cause a deterioration of lung function. Treatment these multidrug-resistant pathogens is associated with severe side-effects, while frequently unsuccessful. Insight on M. genomic evolvement during chronic infection would be beneficial for improving treatment strategies. A longitudinal study enrolling 42 CF was performed at center Berlin, Germany, to elaborate phylogeny and diversification in-patient abscessus. Eleven...
Treatment of ventilated pneumonia is often unsuccessful, even when patients are treated according to current guidelines. Therefore, we aimed investigate the efficacy adjunctive inhaled Tobramycin in with caused by Gram-negative pathogens addition standard systemic treatment.Prospective, multicenter, double-blinded, randomized, placebo-controlled clinical trial.26 medical and surgical ICUs.Patients ventilator-associated pathogens.Fourteen were assigned Inhal group 12 control group. The...
Background: Together with impaired mucociliary clearance, lung disease in cystic fibrosis (CF) is driven by dysregulation of innate and adaptive immunity caused dysfunctional CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), leading to airway infection hyperinflamma-tion. The highly effective modulator therapy (HEMT) elexacaftor/tezacaftor/ivacaftor (ETI) generates substantial improvements clinical outcomes people CF (pwCF) restoration activity. Aberrant immune responses...
Background In Cystic Fibrosis (CF), the airways are often colonized by opportunistic fungi. The most frequently detected mold is Aspergillus fumigatus ( Af ). diseases associated with significant morbidity and mortality. common clinical picture caused allergic bronchopulmonary aspergillosis (ABPA), triggered an immunological reaction against . bronchitis invasive rarely occur in CF as a result of spore colonization germination. Since pulmonary mycoses exacerbations other pathogens overlap...
BackgroundEpidemiology and potential risk factors for cystic fibrosis arthropathy (CFA) were studied in a relevant (CF) patient cohort.MethodsCohort study of patients included the German CF registry 2016-2017. Descriptive analysis, exploratory tests multivariable logistic regression used to assess prevalence CFA associated adult with/without chronic Pseudomonas aeruginosa infection.Results6069 aged from 0 78 years analysed. was observed 4.9% patients. Prevalence significantly higher (8.4%)...
Aspergillus fumigatus (Af) frequently colonizes the airways of patients with cystic fibrosis (CF) and can cause severe diseases, such as allergic bronchopulmonary aspergillosis, Af bronchitis or even pneumonia. However, risk factors, including environmental for acquiring in respiratory tract CF are rarely studied described. The aim this study was to investigate whether urban rural life could affect colonization CF. Due privacy policy, registry data usually not linked patients´ home...
Aspergillus fumigatus (Af) frequently colonizes the respiratory tract of patients with cystic fibrosis (CF). Af is associated loss pulmonary function and allergic bronchopulmonary aspergillosis (ABPA), a hypersensitivity fungal lung disease. Environmental factors have impact on CF patients' variation. The aim this nationwide questionnaire survey was to investigate amount frequent pet contact including species examine potential occurrence colonization ABPA diagnosis in these patients. carried...
People with cystic fibrosis experience bronchopulmonary exacerbations, leading to lung damage, function decline, increased mortality, and a poor health-related quality of life. To date, there are still open questions regarding the rationale for antibiotic use optimal duration therapy. This prospective single-center study (DRKS00012924) analyzes exacerbation treatment over 28 days in 96 pediatric adult people who started oral and/or intravenous therapy an inpatient or outpatient setting after...
Abstract Mycobacterium (M.) abscessus infections in Cystic Fibrosis (CF) patients cause a deterioration of lung function. Treatment these multidrug-resistant pathogens is associated with severe side-effects, while frequently unsuccessful. Insight on M. genomic evolvement during chronic infection would be beneficial for improving treatment strategies. A longitudinal study enrolling 42 CF was performed at center Berlin, Germany, to elaborate phylogeny and diversification in-patient . Eleven...