Mohamed S. Donia

ORCID: 0000-0002-9604-2912
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About
Contact & Profiles
Research Areas
  • Gut microbiota and health
  • Microbial Natural Products and Biosynthesis
  • Marine Sponges and Natural Products
  • Genomics and Phylogenetic Studies
  • Microbial Community Ecology and Physiology
  • Dermatology and Skin Diseases
  • Probiotics and Fermented Foods
  • Clostridium difficile and Clostridium perfringens research
  • Antimicrobial Peptides and Activities
  • Diet and metabolism studies
  • Insect symbiosis and bacterial influences
  • Algal biology and biofuel production
  • Tryptophan and brain disorders
  • Coral and Marine Ecosystems Studies
  • Evolution and Genetic Dynamics
  • RNA and protein synthesis mechanisms
  • Allergic Rhinitis and Sensitization
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Parasite Biology and Host Interactions
  • Cleft Lip and Palate Research
  • Marine Ecology and Invasive Species
  • Pediatric Urology and Nephrology Studies
  • Natural product bioactivities and synthesis
  • Tracheal and airway disorders

Princeton University
2010-2025

Vanderbilt University
2023

Vanderbilt University Medical Center
2023

University of Pennsylvania
2023

Alexandria University
2022

Kafrelsheikh University
2022

Aswan University
2013-2019

University of New Hampshire
2017

University of New Hampshire at Manchester
2017

QB3
2013-2015

Marnix H. Medema Renzo Kottmann Pelin Yilmaz Matthew Cummings John Biggins and 95 more Kai Blin Irene de Bruijn Yit‐Heng Chooi Jan Claesen Roger Coates Pablo Cruz‐Morales Srikanth Duddela Stephanie Düsterhus Daniel Edwards David P. Fewer Neha Garg Christoph Geiger Juan Pablo Gomez‐Escribano Anja Greule Michalis Hadjithomas Anthony S. Haines Eric J. N. Helfrich Matthew L. Hillwig Keishi Ishida Adam C. Jones Carla S. Jones Katrin Jungmann Carsten Kegler Hyun Uk Kim Peter Kötter Daniel Krug Joleen Masschelein Alexey V. Melnik Simone M. Mantovani Emily A. Monroe Marcus A. Moore Nathan A. Moss Hans‐Wilhelm Nützmann Guohui Pan Amrita Pati Daniel Petras F. Jerry Reen Federico Rosconi Zhe Rui Zhenhua Tian Nicholas J. Tobias Yuta Tsunematsu Philipp Wiemann Elizabeth E. Wyckoff Xiaohui Yan Grace Yim Fengan Yu Yunchang Xie Bertrand Aigle Alexander K. Apel Carl J. Balibar Emily P. Balskus Francisco Barona‐Gómez Andreas Bechthold Helge B. Bode Rainer Borriss Sean F. Brady Axel A. Brakhage Patrick Caffrey Yi‐Qiang Cheng Jon Clardy Russell J. Cox René De Mot Stefano Donadio Mohamed S. Donia Wilfred A. van der Donk Pieter C. Dorrestein Seán Doyle Arnold J. M. Driessen Monika Ehling‐Schulz Karl-Dieter Entian Michael A. Fischbach Lena Gerwick William H. Gerwick Harald Gross Bertolt Gust Christian Hertweck Monica Höfte Susan E. Jensen Jianhua Ju Leonard Katz Leonard Kaysser Jonathan L. Klassen Nancy P. Keller Ján Kormanec Oscar P. Kuipers Tomohisa Kuzuyama Nikos C. Kyrpides Hyung-Jin Kwon Sylvie Lautru Rob Lavigne Chia Y. Lee Linquan Bai Xinyu Liu Wen Liu

A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded biosynthetic gene clusters. Information about these clusters, is currently dispersed throughout the literature, making it difficult exploit. To facilitate consistent systematic deposition retrieval data on we propose Minimum a Biosynthetic Gene cluster (MIBiG) standard.

10.1038/nchembio.1890 article EN cc-by-nc-sa Nature Chemical Biology 2015-08-18

Tolerogenic T cells need probiotics CD4 + CD8αα double-positive intraepithelial lymphocytes (DP IELs) are a recently discovered class of intestinal believed to take part in variety immune responses, including oral tolerance. These absent germ-free mice, but the mechanisms driving their development unclear. Cervantes-Barragan et al. found that particular species probiotic bacteria, Lactobacillus reuteri , induces DP IELs. This does not occur by stimulating system directly. Instead, L....

10.1126/science.aah5825 article EN Science 2017-08-04

Secondary metabolites are ubiquitous in bacteria, but by definition, they thought to be nonessential. Highly toxic secondary such as patellazoles have been isolated from marine tunicates, where their exceptional potency and abundance implies a role chemical defense, biological source is unknown. Here, we describe the association of tunicate Lissoclinum patella with symbiotic α-proteobacterium, Candidatus Endolissoclinum faulkneri, present evidence that bacterium synthesizes patellazoles. We...

10.1073/pnas.1213820109 article EN Proceedings of the National Academy of Sciences 2012-11-26

The relationship between tunicates and the uncultivated cyanobacterium Prochloron didemni has long provided a model symbiosis. P. is required for survival of animals such as Lissoclinum patella also makes secondary metabolites pharmaceutical interest. Here, we present metagenomes, chemistry, microbiomes four related L. tunicate samples from wide geographical range tropical Pacific. remarkably similar genomes are most complex so far assembled organisms. Although not been stably cultivated...

10.1073/pnas.1111712108 article EN Proceedings of the National Academy of Sciences 2011-11-28

Prospecting for drugs in the microbiome The is an important source of natural products that can profoundly influence health and disease host. Sugimoto et al. constructed a modular, probabilistic strategy called MetaBGC to uncover biosynthetic gene clusters (BGCs) human samples (see Perspective by Henke Clardy). authors found geographic strain-specific distributions BGCs. By zeroing on two type II aromatic polyketides, native organisms were identified, BGCs reconstructed Streptomyces ,...

10.1126/science.aax9176 article EN Science 2019-10-03

10.1016/j.chembiol.2011.01.019 article EN publisher-specific-oa Chemistry & Biology 2011-04-01

The enzymatic basis of ribosomal peptide natural product prenylation has not been reported. Here, we characterize a prenyltransferase, LynF, from the TruF enzyme family. LynF is first characterized representative protein family, which responsible for both reverse- and forward-O-prenylation tyrosine, serine, threonine in cyclic peptides known as cyanobactins. We show that reverse O-prenylates tyrosine macrocyclic peptides. Based upon these results, propose family prenylates mature peptides,...

10.1021/ja205458h article EN Journal of the American Chemical Society 2011-07-18

The cyanobactin ribosomal peptide (RP) natural product pathway was manipulated to incorporate multiple tandem mutations and non-proteinogenic amino acids, using eight heterologous components simultaneously expressed in Escherichia coli . These studies reveal the potential of RPs for rational synthesis complex, new small molecules over multiple-step biosynthetic pathways simple genetic engineering.

10.1021/ja208278k article EN Journal of the American Chemical Society 2011-11-22

Consumption of glucosinolates, pro-drug-like metabolites abundant in Brassica vegetables, has been associated with decreased risk certain cancers. Gut microbiota have the ability to metabolize generating chemopreventive isothiocyanates. Here, we identify a genetic and biochemical basis for activation glucosinolates isothiocyanates by Bacteroides thetaiotaomicron, prominent gut commensal species. Using genome-wide transposon insertion screen, identified an operon required glucosinolate...

10.1016/j.cell.2020.01.023 article EN publisher-specific-oa Cell 2020-02-01

Microbial natural products constitute a wide variety of chemical compounds, many which can have antibiotic, antiviral, or anticancer properties that make them interesting for clinical purposes. Natural product classes include polyketides (PKs), nonribosomal peptides (NRPs), and ribosomally synthesized post-translationally modified (RiPPs). While variants biosynthetic gene clusters (BGCs) known are easy to identify in genome sequences, BGCs new compound escape attention. In particular,...

10.1371/journal.pbio.3001026 article EN cc-by PLoS Biology 2020-12-22

Chemical defense against predators is widespread in natural ecosystems. Occasionally, taxonomically distant organisms share the same chemical. Here, we describe an unusual tripartite marine symbiosis, which intracellular bacterial symbiont ("Candidatus Endobryopsis kahalalidefaciens") uses a diverse array of biosynthetic enzymes to convert simple substrates into library complex molecules (the kahalalides) for chemical host, alga Bryopsis sp., predation. The kahalalides are subsequently...

10.1126/science.aaw6732 article EN Science 2019-06-13
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