A5026057788- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Fungal and yeast genetics research
- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Essential Oils and Antimicrobial Activity
- Salmonella and Campylobacter epidemiology
- DNA Repair Mechanisms
- Fungal Biology and Applications
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Photodynamic Therapy Research Studies
- Microtubule and mitosis dynamics
- Microbial Natural Products and Biosynthesis
- Bacterial Identification and Susceptibility Testing
- Laser Applications in Dentistry and Medicine
- Plant-Microbe Interactions and Immunity
- Bacterial biofilms and quorum sensing
- Bone Tissue Engineering Materials
- Infectious Diseases and Mycology
- Signaling Pathways in Disease
- Seaweed-derived Bioactive Compounds
- Cystic Fibrosis Research Advances
- Biocrusts and Microbial Ecology
- Enterobacteriaceae and Cronobacter Research
Universidade de São Paulo
2016-2025
Universidade de Ribeirão Preto
2014-2024
SUPERA Park of Innovation and Technology of Ribeirão Preto
2020-2023
Universidade do Estado da Bahia
2023
Zero to Three
2012
University of Göttingen
2012
ABSTRACT To increase the frequency of homologous recombination, we inactivated KU80 homologue in Aspergillus fumigatus (named akuB ). Homologous integration reached about 80% for both calcineurin A ( calA ) and polyketide synthase pksP (alb1 genes mutant to 3 5%, respectively, when using a wild-type A. strain. Deletion had no influence on pathogenicity low-dose murine infection model.
Summary The protein phosphatase calcineurin is an important mediator connecting calcium‐dependent signalling to various cellular responses in multiple organisms. In fungi acts largely through regulating Crz1p‐like transcription factors. Here we characterize Aspergillus fumigatus CRZ1 homologue, CrzA and demonstrate its mediation of tolerance increased concentrations calcium manganese. addition acute sensitivitiy these ions, decreased conidiation, the crz A null mutant suffers altered...
The emerging pathogen Candida auris is an fungal that was associated with nosocomial infectious outbreaks. Its worldwide incidence and the multidrug-resistant strains highlight urgency for novel effective antifungal treatment strategies. Lippia sidoides essential oil (LSEO) proved activity, including anti-Candida. However, it may undergo irreversible changes when in contact external agents without adequate protection. Herein, we encapsulated LSEO nanostructured lipid carriers (NLC)...
In recent decades, the recurrence and mortality rates of fungal infections have increased, likely due to antifungal resistance insufficient attention from healthcare authorities. This trend highlights urgent need for new treatments, with essential oils (EOs) emerging as promising alternatives. study focuses on characterization, nanoencapsulation, evaluation EO Lippia origanoides Kunth - pepper-rosemary toxicity activity against filamentous fungi yeasts, a particular emphasis influence...
Invasive aspergillosis is predominantly caused by Aspergillus fumigatus, and adaptations to stresses experienced within the human host are a prerequisite for survival virulence strategies of pathogen. The central signal transduction pathway operating during hyperosmotic stress high osmolarity glycerol mitogen-activated protein kinase cascade. A. fumigatus MpkC SakA, orthologues Saccharomyces cerevisiae Hog1p, constitute primary regulator response. We compared wild-type transcriptional...
Cocoa fermentation is a spontaneous process shaped by variable microbial ecosystem which assembled due to cross-feeding relationship among yeasts and bacteria, resulting in synchronized succession started yeasts, followed lactic acid bacteria (LAB) finalized acetic (AAB). Several studies have indicated the effect of interactions food ecosystems highlighting importance quorum sensing (QS) bacterial adaptation harsh environments modulating several phenotypes such as biofilm formation,...
INTRODUCTION: The clinical manifestations of cryptococcosis are usually associated with the infecting agents Cryptococcus neoformans (CN) and C. gattii (CG) species complexes host. In this study, non-HIV-infected patients, at a university hospital in southeastern Brazil, had epidemiological data cryptococcal disease isolated species: CN - 24 patients CG 12 patients. METHODS: comparison was comprised demographic data, predisposing factors, laboratory manifestations, outcomes treated between...
Summary Defects in the COP9 signalosome (CSN) impair multicellular development, including embryonic plant or animal death a block sexual development of fungus Aspergillus nidulans. CSN deneddylates cullin‐RING ligases (CRLs), which are activated by covalent linkage to ubiquitin‐like NEDD8. Deneddylation allows CRL disassembly for subsequent reassembly. An attractive hypothesis is consecutive order CRLs demands repeated cycles neddylation and deneddylation reassembling CRLs. Interruption...
The impact of fungal diseases and the development antimicrobial agents against pathogenic fungi have emerged as a main global healthcare challenge. In this study, antifungal activity silver-loaded hydroxyapatite (Ag/HAP) nanocomposites (NCs) with different Ag content synthesized by one-pot microwave-assisted solvothermal method was evaluated sensitive resistant Candida species. NCs' composition morphology were characterized X-ray diffraction, field emission scanning electron microscopy,...
Serratia marcescens, an opportunistic nosocomial Gram-negative bacterium pathogen, has emerged as important cause of healthcare-associated infections owing to its acquisition antimicrobial resistance genes (ARGs) and virulence factor determinants. Four carbapenem-resistant S. marcescens strains were recovered from patients admitted different hospitals in 2017 2018. We assessed the context, well genetic similarities four Brazilian strains, compared genomes these isolates with whole genome...
The filamentous fungus Aspergillus nidulans has been used as a fungal model system to study the regulation of xylanase production. These genes are activated at transcriptional level by master regulator factor XlnR and repressed carbon catabolite repression (CCR) mediated wide-domain repressor CreA. Here, we screened collection 42 A. F-box deletion mutants grown either in xylose or xylan single source presence glucose analog 2-deoxy-d-glucose, aiming identify that have deregulated induction....
Summary Primary Cutaneous Cryptococcosis is an uncommon infection caused by the yeast Cryptococcus neoformans and C. gattii . Few case reports are available in literature describing detail primary cutaneous cryptococcosis due to immunocompetent patients. Herein, we present a of 68‐year‐old male patient with erythematous nodular lesions on right forearm mating‐type α molecular type VGI The virulence factors test was performed for capsule diameter, melanin production phospholipase activity. In...
One of the factors causing treatment failure in cryptococcosis is resistance Cryptococcus spp. to antifungal drugs, which has motivated susceptibility assessment isolates from patients with cryptococcosis, different clinical conditions and infections outcomes. Clinical three groups were studied present investigation: 19 HIV-positive relapsing and/or refractory meningitis (Group 1), 30 who experienced a single limited episode 2), HIV-negative 3). Eighty C. neoformans var. grubii 7 gattii...