A5028852600- Analytical Methods in Pharmaceuticals
- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Pesticide Residue Analysis and Safety
- Electrochemical Analysis and Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Public Health in Brazil
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Research on Leishmaniasis Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Biochemical Analysis and Sensing Techniques
- Central Venous Catheters and Hemodialysis
- Heavy metals in environment
- Chemistry and Chemical Engineering
- Probiotics and Fermented Foods
- Advancements in Transdermal Drug Delivery
- Pharmacogenetics and Drug Metabolism
- Peroxisome Proliferator-Activated Receptors
- Chemical Analysis and Environmental Impact
- Heavy Metals in Plants
- Viral Infectious Diseases and Gene Expression in Insects
- Synthesis and biological activity
- Lysosomal Storage Disorders Research
- Neonatal Health and Biochemistry
Universidade Federal de São Paulo
2016-2025
Instituto de Ciências Farmacêuticas
2018-2024
Universidade de São Paulo
2010-2013
Universidade de Ribeirão Preto
2011-2013
Universidade Estadual de Londrina
2006
Short-Chain Fatty Acids (SCFAs) are a product of the fermentation resistant starches and dietary fibers by gut microbiota. The most important SCFA acetate (C2), propionate (C3) butyrate (C4). These metabolites formed absorbed in colon then transported through hepatic vein to liver. SCFAs more concentrated intestinal lumen than serum. Butyrate is largely consumed epithelium, liver periphery. act on many cells including components immune system epithelial two main mechanisms: activation...
The processing of coffee consists on the separation grains from other parts fruit, then roasted and extracted to obtain beverage that is so appreciated worldwide. Several studies have dedicated efforts treat residue processing, while recovering lignols industrial interest. Given this scenario, nutrients in husk can enhance microbial growth, providing optimal conditions for microorganisms produce metabolites may medicinal properties. Deep eutectic solvents (DES) are a class and/or catalysts...
Abstract Knowing that microbial transformations of compounds play vital roles in the preparation new derivatives with biological activities, risperidone and its chiral metabolites were determined by capillary electrophoresis hollow fiber liquid‐phase microextraction after a fungal biotransformation study liquid culture medium. The analytes extracted from 1 mL medium into 1‐octanol impregnated pores fiber, an acid acceptor solution inside polypropylene fiber. electrophoretic separations...
Leishmaniasis, caused by the protozoan
Abstract: Water pollution has been an increasing concern for the authorities responsible planning and executing public policies. In this qualitative research, we have discussed most sold pharmaceuticals in São Paulo Metropolitan Region, Brazil, compared policies focused on environmental issues among countries/regions. For that, data provided by Close-Up International related to sales of medicines Region between April/2016 April/2017 were collected processed identify quantify pharmaceutical...
Abstract A three‐phase hollow‐fiber liquid‐phase microextraction method for the analysis of rosiglitazone and its metabolites N ‐desmethyl ρ‐hydroxy in microsomal preparations is described first time. The drug HPLC determination was carried out using an X‐Terra RP‐18 column, at 22°C. mobile phase composed water, acetonitrile acetic acid (85:15:0.5, v/v/v) detection performed 245 nm. procedure optimized multifactorial experiments following optimal condition established: sample agitation 1750...
Levetiracetam (LEV) is an antiepileptic drug that clinically effective in generalized and partial epilepsy syndromes. The use of this has been increasing clinical practice intra- or -interindividual variability exhibited for special population. For reason, bioanalytical methods are required monitoring biological matrices. So work presents a dispersive liquid-liquid microextraction method followed by gas chromatography-mass spectrometry (DLLME-GC-MS) LEV quantification human plasma. However,...
Pioglitazone (PGZ), a thiazolidinedione antidiabetic agent, is reported as potent and selective activator of peroxisome proliferator-activated receptor γ (PPAR γ). This drug has been widely prescribed for the treatment Type 2 diabetes mellitus. In this regard, manuscript presents, first time, an alternative electrophoretic method PGZ its main metabolites determination in rat liver microsomal fraction. The analyses were performed using uncoated fused-silica capillary 50 μm id, 48 cm total...
After oral administration dipyrone is rapidly hydrolyzed to 4-methylaminoantipyrine, which absorbed and further metabolized 4-formylaminoantipyrine 4-aminoantipyrine, acetylated by a polymorphic N-acetyltransferase system 4-acetylaminoantipyrine. To evaluate the presence of metabolites in different rat matrices after intraperitoneal administration, an analytical method was developed validated.The four main were extracted from plasma, cerebrospinal fluid hypothalamus samples LLE prior...
An ultra-fast method for the simultaneous determination of heavy metals in Passiflora incarnata tea by capillary electrophoresis (CE) using a short-end injection combined with multivariate analysis was proposed. Separation conducted hydrodynamic (5 s at 0.5 psi) procedure fused uncoated silica (50 cm total length, 10.2 effective 50 µm i.d.) separation time less than 2 min. indirect UV detection 214 nm employed imidazole as chromophore. The buffer used 6 mmol/L hydroxybutyric acid (HIBA)....
Polyamines are low molecular weight compounds that present in all living organisms. They related to the pathological processes, and have been studied as biomarkers for tumor progression, being analyzed patients' biological fluids. However, polyamines can undergo degradation serum samples, depending on storage conditions, which impairs their quantification these matrices. In this work, capillary electrophoresis using indirect ultraviolet detection has developed applied evaluate stability of...