A5079886535- Research on Leishmaniasis Studies
- Hibiscus Plant Research Studies
- Advanced Statistical Process Monitoring
- Advanced Drug Delivery Systems
- Protein Interaction Studies and Fluorescence Analysis
- Synthesis and Biological Evaluation
- Advancements in Transdermal Drug Delivery
- Toxin Mechanisms and Immunotoxins
- Herpesvirus Infections and Treatments
- Scientific Measurement and Uncertainty Evaluation
- Monoclonal and Polyclonal Antibodies Research
- Statistical Methods in Clinical Trials
- Bee Products Chemical Analysis
- Analytical Methods in Pharmaceuticals
- Surfactants and Colloidal Systems
- Insect Pest Control Strategies
- Nanoparticles: synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- RNA Interference and Gene Delivery
- Food Chemistry and Fat Analysis
- Proteins in Food Systems
- Blood Coagulation and Thrombosis Mechanisms
- Hepatitis C virus research
- Statistical and Computational Modeling
Universidade de São Paulo
2015-2023
Universidade Cidade de São Paulo
2017-2021
Instituto Butantan
2019
Buparvaquone (BPQ), a veterinary drug, was formulated as nanostructured lipid carriers (NLC) for leishmaniases treatment. The formulation design addressed poor water solubility of BPQ and lack human drug delivery system. DSC/TG microscopy methods were used solid lipids screening. Softisan® 154 showed highest in both methods. liquid using HPLC revealed Miglyol® 812 the best option. Response surface methodology (RSM) to identify optimal Softisan154 : Miglyol ratios (7 10 2 1) Kolliphor® P188...
Leishmaniasis, a neglected tropical disease, is prevalent in 98 countries with the occurrence of 1.3 million new cases annually. The conventional therapy for visceral leishmaniasis requires hospitalization due to severe adverse effects drugs, which are administered parenterally. Buparvaquone (BPQ) showed vitro activity against leishmania parasites; nevertheless, it has failed vivo tests its low aqueous solubility. Though, lipid nanoparticles can overcome this holdback. In study we tested...
Hydroxymethylnitrofurazone (NFOH) is a new compound with potential leishmanicidal and trypanocidal activity. Despite its effectiveness, the formulators have to overcome poor aqueous solubility. Recently, polymeric nano-scale drug delivery systems proposed for treatment of neglected diseases. As several studies confirmed advantages such formulations, this approach provides analytical challenges, including need detect trace amounts drug. A suitable method was developed validated NFOH...
In this study, the manufacturing process of lamivudine (3TC) and zidovudine (AZT) tablets (150+300 mg respectively) was evaluated using statistical control (SPC) tools. These medicines are manufactured by Fundação para o Remédio Popular “Chopin Tavares de Lima” (FURP) laboratory, distributed free charge to patients infected with HIV Ministry Health DST/AIDS national program. Data 529 batches from 2012 2015 were collected. The critical quality attributes weight variation, uniformity dosage...