A5102707319- Research on Leishmaniasis Studies
- Dendrimers and Hyperbranched Polymers
- Malaria Research and Control
- RNA Interference and Gene Delivery
- Electrochemical Analysis and Applications
- Science and Education Research
- Trypanosoma species research and implications
- Biotechnology and Related Fields
- Electrochemical sensors and biosensors
- Chemistry Education and Research
- Public Health in Brazil
- Crystallization and Solubility Studies
- Tuberculosis Research and Epidemiology
- Synthesis and Biological Evaluation
- Mosquito-borne diseases and control
- X-ray Diffraction in Crystallography
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Analysis
- HIV/AIDS drug development and treatment
- Analytical Chemistry and Sensors
- Synthesis of Tetrazole Derivatives
- Science, Research, and Medicine
- Nanocomposite Films for Food Packaging
- Drug-Induced Hepatotoxicity and Protection
- Pharmaceutical Practices and Patient Outcomes
Universidade de São Paulo
2015-2024
Instituto de Ciências Farmacêuticas
1983-2020
New York City College of Technology
2019
City University of New York
2019
Universidade Cidade de São Paulo
2015-2017
Universidad San Pedro
2010
Universidade Estadual Paulista (Unesp)
1999
AND RECENT ADVANCES.Chitin and chitosan are copolymers build from N-acetyl-D-glucosamine D-glucosamine.The former is widely found in nature yields the latter on deacetylation.The being used for several purposes.Since 1977, when First International Conference Chitin Chitosan was held Boston, USA, interest chitin has remarkably increased.This review emphasizes pharmaceutical applications of its derivatives, presents recent advances.Some therapeutical these polymers also discussed.
Dendrimers are versatile hyperbranched molecules, which have deserved attention especially for their potential in many applications, including biological. Peptide dendrimers comprise interesting classes of dendrimers, and use has been emphasized as a drug/bioactive compound delivery system, mostly the antineoplastic area. The bioactive molecules can be covalently linked or entrapped inside peptide derivative. Self-assembled nanocarriers recent trend design systems, pH-sensitive carriers, one...
Pyrazinamide was condensed with the poly(ethylene glycol)-poly(aspartic acid) copolymer (PEG-PASP), a micelle-forming derivative obtained that characterized in terms of its critical micelle concentration (CMC) and diameter. The CMC found by observing solubility Sudan III Poly(ethylene glycol)-poly(pyrazinamidomethyl aspartate) (PEG-PASP-PZA) solutions. mean diameter PEG-PASP-PZA micelles, analyzing dynamic light-scattering data, 78.2 nm. derivative, when assayed for anti-Mycobacterium...
The aim of this paper was to emphasize the importance prodrug design therapy, by examining examples available on Brazilian pharmaceutical market. principles are briefly discussed herein. Examples prodrugs from many important therapeutic classes shown and their advantages relative drugs they derived also discussed. Considering these classes, both therapy economic standpoints, is a very valuable aspect in research new for industry as whole.
Chagas' disease is a parasitic infection widely distributed throughout Latin America, with devastating consequences in terms of human morbidity and mortality. Cruzain, the major cysteine protease from Trypanosoma cruzi, an attractive target for antitrypanosomal chemotherapy. In present work, classical two-dimensional quantitative structure-activity relationships (2D QSAR) hologram QSAR (HQSAR) studies were performed on training set 45 thiosemicarbazone semicarbazone derivatives as inhibitors...
The biological action of drugs with potential antichagasic activities can be better understood by knowing their reduction mechanism. For this proposal, the electrochemical nitrofurazone (NF) and its analogues, nitrofurfurilidene thiosemicarbazone (NFS), nitrothiophene semicarbazone (NT), (NTS), was studied differential pulse cyclic voltammetries chronoamperometry in aqueous medium using a glassy carbon electrode. Those three synthetic analogues have oxygen sulfur atoms arranged between...