A5076027814- Gut microbiota and health
- Diet and metabolism studies
- Tryptophan and brain disorders
- Sleep and related disorders
- Stress Responses and Cortisol
- Gastrointestinal motility and disorders
- Eicosanoids and Hypertension Pharmacology
- Alcohol Consumption and Health Effects
- Neuroendocrine regulation and behavior
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
Northwestern University
2015-2024
Circadian (United States)
2021-2024
It has been established in recent years that the gut microbiome plays a role health and disease, potentially via alterations metabolites influence host physiology. Although sleep disruption dysbiosis have associated with many of same diseases, studies investigating context yielded inconsistent results, not assessed fecal metabolome. We exposed mice to five days followed by four ad libitum recovery sleep, metabolome at multiple timepoints using 16S rRNA gene amplicons untargeted LC-MS/MS mass...
Sleep disruption is a challenging and exceedingly common physiological state that contributes to wide range of biochemical molecular perturbations has been linked numerous adverse health outcomes. Modern society exerts significant pressure on the sleep/wake cycle via myriad factors, including exposure electric light, psychological stressors, technological interconnection, jet travel, shift work, widespread use sleep-affecting compounds. Interestingly, recent research identified link between...
Background Chronic alcohol exposure exerts numerous adverse effects, although the specific mechanisms underlying these negative effects on different tissues are not completely understood. Alcohol also affects core properties of circadian clock system, and it has been shown that disruption rhythms confers vulnerability to alcohol-induced pathology gastrointestinal barrier liver. Despite findings, little is known molecular interactions between especially regarding implications for...
Sleep deprivation induces systemic inflammation that may contribute to stress vulnerability and other pathologies. We tested the hypothesis immunization with heat-killed Mycobacterium vaccae NCTC 11659 (MV), an environmental bacterium immunoregulatory anti-inflammatory properties, prevents negative impacts of 5 days sleep disruption on stress-induced changes in sleep, behavior, physiology mice.In a 2 × experimental design, male C57BL/6N mice were given injections either MV or vehicle -17,...
Despite substantial evidence supporting the efficacy of prebiotics for promoting host health and stress resilience, few experiments present documenting dynamic changes in microbial ecology fecal microbial-modified metabolites across time. Furthermore, literature reports a lack reproducible effects on specific bacteria bacterial-modified metabolites. The current examined whether consumption diets enriched (galactooligosaccharides, GOS polydextrose, PDX) compared to control diet, would...
Despite substantial evidence supporting the efficacy of prebiotics for promoting host health and stress resilience, few experiments present documenting dynamic changes in microbial ecology fecal microbially modified metabolites over time. Furthermore, literature reports a lack reproducible effects on specific bacteria bacterial-modified metabolites. The current examined whether consumption diets enriched (galactooligosaccharides (GOS) polydextrose (PDX)), compared to control diet, would...
Because regular sleep disruption can increase vulnerability to stress-related psychiatric disorders, there is a need explore novel countermeasures stress resilience after inadequate sleep. Immunization with heat-killed Mycobacterium vaccae NCTC11659 (MV), an environmental bacterium and immunomodulator, chronic in mice. We therefore tested the hypothesis that MV immunization would prevent negative impacts of five days on stress-induced changes 120 male C57BL/6N mice were implanted EEG/EMG...
Abstract Because regular sleep disruption can increase vulnerability to stress-related psychiatric disorders, there is a need explore novel countermeasures stress resilience after inadequate sleep. In this study, we explored the impact of 5 days intermittent on acute social defeat in mice, and investigated ability environmental, immunomodulatory bacterium Mycobacterium vaccae NCTC 11659 (MV) promote that context. We found mice receiving plus developed behavioral phenotypes had some features...
Abstract Chronic disruption of rhythms (CDR) impacts sleep and can result in circadian misalignment physiological systems, which turn is associated with increased disease risk. Exposure to repeated or severe stressors also disturbs diurnal rhythms. Prebiotic nutrients produce favorable changes gut microbial ecology, the metabolome, reduce several negative acute stressor exposure, including disturbed sleep, core body temperature rhythmicity, dysbiosis. This study tested hypothesis whether...